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Heparin-Derived The...
Heparin-Derived Theranostic Nanoprobes Overcome the Blood-Brain Barrier and Target Glioma in Murine Model
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- Samanta, Sumanta (author)
- Tampere Univ, Bioengn & Nanomed Lab, Fac Med & Hlth Technol, Tampere 33720, Finland
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- Le Joncour, Vadim (author)
- Univ Helsinki, Translat Canc Med Res Program, Fac Med, Haartmaninkatu 8, Helsinki 00290, Uusimaa, Finland
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- Wegrzyniak, Olivia (author)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Institutionen för läkemedelskemi
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- Rangasami, Vignesh K. (author)
- Uppsala universitet,Polymerkemi,Tampere Univ, Bioengn & Nanomed Lab, Fac Med & Hlth Technol, Tampere 33720, Finland
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- Ali-Loytty, Harri (author)
- Tampere Univ, Surface Sci Grp, Photon Lab, POB 692, FI-33014 Tampere, Finland
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- Hong, Taehun (author)
- Univ Tokyo, Dept Bioengn, Grad Sch Engn, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1138656, Japan
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- Selvaraju, Ram Kumar (author)
- Uppsala universitet,Institutionen för läkemedelskemi,Science for Life Laboratory, SciLifeLab
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- Åberg, Ola, 1978- (author)
- Uppsala universitet,Institutionen för läkemedelskemi,Science for Life Laboratory, SciLifeLab
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- Hilborn, Jöns, 1956- (author)
- Uppsala universitet,Polymerkemi
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- Laakkonen, Pirjo (author)
- Univ Helsinki, Translat Canc Med Res Program, Fac Med, Haartmaninkatu 8, Helsinki 00290, Uusimaa, Finland
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- Varghese, Oommen P., 1977- (author)
- Uppsala universitet,Polymerkemi,Science for Life Laboratory, SciLifeLab
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- Eriksson, Olof (author)
- Uppsala universitet,Institutionen för läkemedelskemi,Science for Life Laboratory, SciLifeLab
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- Cabral, Horacio (author)
- Univ Tokyo, Dept Bioengn, Grad Sch Engn, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1138656, Japan
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- Oommen, Oommen P. (author)
- Tampere Univ, Bioengn & Nanomed Lab, Fac Med & Hlth Technol, Tampere 33720, Finland
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(creator_code:org_t)
- 2022-03-23
- 2022
- English.
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In: Advanced Therapeutics. - : John Wiley & Sons. - 2366-3987. ; 5:6
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://doi.org/10.1...
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Abstract
Subject headings
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- The poor permeability of theranostic agents across the blood-brain barrier (BBB) significantly hampers the development of new treatment modalities for neurological diseases. A new biomimetic nanocarrier is discovered using heparin (HP) that effectively passes the BBB and targets glioblastoma. Specifically, HP-coated gold nanoparticles (HP-AuNPs) are designed that are labeled with three different imaging modalities namely, fluorescein (FITC-HP-AuNP), radioisotope (68)Gallium (Ga-68-HP-AuNPs), and MRI active gadolinium (Gd-HP-AuNPs). The systemic infusion of FITC-HP-AuNPs in three different mouse strains (C57BL/6JRj, FVB, and NMRI-nude) displays excellent penetration and reveals uniform distribution of fluorescent particles in the brain parenchyma (69-86%) with some accumulation in neurons (8-18%) and microglia (4-10%). Tail-vein administration of radiolabeled Ga-68-HP-AuNPs in healthy rats also show Ga-68-HP-AuNP inside the brain parenchyma and in areas containing cerebrospinal fluid, such as the lateral ventricles, the cerebellum, and brain stem. Finally, tail-vein administration of Gd-HP-AuNPs (that displays approximate to threefold higher relaxivity than that of commercial Gd-DTPA) in an orthotopic glioblastoma (U87MG xenograft) model in nude mice demonstrates enrichment of T1-contrast at the intracranial tumor with a gradual increase in the contrast in the tumor region between 1 and 3 h. It is believed, the finding offers the untapped potential of HP-derived-NPs to deliver cargo molecules for treating neurological disorders.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- blood-brain barriers
- glioma
- heparin
- nanoparticles
- radioimaging
Publication and Content Type
- ref (subject category)
- art (subject category)
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Samanta, Sumanta
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Le Joncour, Vadi ...
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Wegrzyniak, Oliv ...
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Rangasami, Vigne ...
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Ali-Loytty, Harr ...
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Hong, Taehun
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Selvaraju, Ram K ...
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Åberg, Ola, 1978 ...
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Hilborn, Jöns, 1 ...
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Laakkonen, Pirjo
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Varghese, Oommen ...
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Eriksson, Olof
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Cabral, Horacio
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Oommen, Oommen P ...
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