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Cost of healthcare ...
Cost of healthcare utilization associated with incident cardiovascular and renal disease in individuals with type 2 diabetes : A multinational, observational study across 12 countries
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- Norhammar, Anna (author)
- Karolinska Institutet
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- Bodegard, Johan (author)
- AstraZeneca, Oslo, Norway.
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- Eriksson, Jan W. (author)
- Uppsala universitet,Klinisk diabetologi och metabolism
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- Haller, Hermann (author)
- Hannover Med Sch, Div Nephrol, Hannover, Germany.
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- Linssen, Gerard C. M. (author)
- Hosp Grp Twente, Dept Cardiol, Almelo, Netherlands.;Hosp Grp Twente, Dept Cardiol, Hengelo, Netherlands.
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- Banerjee, Amitava (author)
- UCL, Inst Hlth Informat, London, England.;Univ Coll London Hosp, Dept Cardiol, London, England.
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- Karasik, Avraham (author)
- Maccabi Healthcare Serv, Maccabi Inst Res & Innovat, Tel Aviv, Israel.
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- Mamouris, Pavlos (author)
- Katholieke Univ Leuven, Acad Ctr Gen Practice, Leuven, Belgium.
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- Tangri, Navdeep (author)
- Univ Manitoba, Dept Med & Community Hlth Sci, Winnipeg, MB, Canada.
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- Taveira-Gomes, Tiago (author)
- Univ Porto, Fac Med, Dept Community Med Informat & Decis Hlth, Porto, Portugal.
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- Maggioni, Aldo P. (author)
- ANMCO Res Ctr, Florence, Italy.;Maria Cecilia Hosp, GVM Care & Res, Cotignola, Italy.
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- Botana, Manuel (author)
- Lucus Augusti Univ Hosp, Endocrinol Serv, Lugo, Spain.
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- Thuresson, Marcus (author)
- Statisticon AB, Uppsala, Sweden.
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- Okami, Suguru (author)
- AstraZeneca, Osaka, Japan.
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- Yajima, Toshitaka (author)
- AstraZeneca, Osaka, Japan.
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- Kadowaki, Takashi (author)
- Tranomon Hosp, Tokyo, Japan.
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- Birkeland, Kåre I. (author)
- Oslo Univ Hosp, Dept Transplantat Med, Oslo, Norway.;Univ Oslo, Oslo, Norway.
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Karolinska Institutet AstraZeneca, Oslo, Norway (creator_code:org_t)
- 2022-04-19
- 2022
- English.
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In: Diabetes, obesity and metabolism. - : John Wiley & Sons. - 1462-8902 .- 1463-1326. ; 24:7, s. 1277-1287
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Abstract
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- AimTo examine how the development of cardiovascular and renal disease (CVRD) translates to hospital healthcare costs in individuals with type 2 diabetes (T2D) initially free from CVRD.MethodsData were obtained from the digital healthcare systems of 12 nations using a prespecified protocol. A fixed country-specific index date of 1 January was chosen to secure sufficient cohort disease history and maximal follow-up, varying between each nation from 2006 to 2017. At index, all individuals were free from any diagnoses of CVRD (including heart failure [HF], chronic kidney disease [CKD], coronary ischaemic disease, stroke, myocardial infarction [MI], or peripheral artery disease [PAD]). Outcomes during follow-up were hospital visits for CKD, HF, MI, stroke, and PAD. Hospital healthcare costs obtained from six countries, representing 68% of the total study population, were cumulatively summarized for CVRD events occurring during follow-up.ResultsIn total, 1.2 million CVRD-free individuals with T2D were identified and followed for 4.5 years (mean), that is, 4.9 million patient-years. The proportion of individuals indexed before 2010 was 18% (n = 207 137); 2010-2015, 31% (361 175); and after 2015, 52% (609 095). Overall, 184 420 (15.7%) developed CVRD, of which cardiorenal disease was most frequently the first disease to develop (59.7%), consisting of 23.0% HF and 36.7% CKD, and more common than stroke (16.9%), MI (13.7%), and PAD (9.7%). The total cumulative cost for CVRD was US$1 billion, of which 59.0% was attributed to cardiorenal disease, 3-, 5-, and 6-fold times greater than the costs for stroke, MI, and PAD, respectively.ConclusionAcross all nations, HF or CKD was the most frequent CVRD manifestation to develop in a low-risk population with T2D, accounting for the highest proportion of hospital healthcare costs. These novel findings highlight the importance of cardiorenal awareness when planning healthcare.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Keyword
- cardiovascular disease
- diabetic nephropathy
- health economics
- heart failure
- SGLT2 inhibitor
- type 2 diabetes
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Norhammar, Anna
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Bodegard, Johan
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Eriksson, Jan W.
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Haller, Hermann
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Linssen, Gerard ...
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Banerjee, Amitav ...
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show more...
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Karasik, Avraham
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Mamouris, Pavlos
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Tangri, Navdeep
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Taveira-Gomes, T ...
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Maggioni, Aldo P ...
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Botana, Manuel
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Thuresson, Marcu ...
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Okami, Suguru
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Yajima, Toshitak ...
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Kadowaki, Takash ...
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Birkeland, Kåre ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
- Articles in the publication
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Diabetes, obesit ...
- By the university
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Uppsala University
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Karolinska Institutet