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Gut microbiota-deri...
Gut microbiota-derived metabolite trimethylamine-N-oxide and multiple health outcomes : an umbrella review and updated meta-analysis
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- Li, Doudou (author)
- Zhejiang Univ, Sch Med, Dept Big Data Hlth Sci, Sch Publ Hlth,Ctr Clin Big Data & Analyt,Affiliat, Hangzhou, Peoples R China
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- Lu, Ying (author)
- Zhejiang Univ, Sch Med, Dept Big Data Hlth Sci, Sch Publ Hlth,Ctr Clin Big Data & Analyt,Affiliat, Hangzhou, Peoples R China
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- Yuan, Shuai (author)
- Karolinska Institutet
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- Cai, Xiaxia (author)
- Capital Med Univ, Beijing Key Lab Environm Toxicol, Sch Publ Hlth, Dept Nutr & Food Hyg, Beijing, Peoples R China
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- He, Yuan (author)
- Natl Res Inst Hlth & Family Planning, Beijing, Peoples R China
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- Chen, Jie (author)
- Zhejiang Univ, Sch Med, Dept Big Data Hlth Sci, Sch Publ Hlth,Ctr Clin Big Data & Analyt,Affiliat, Hangzhou, Peoples R China
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- Wu, Qiong (author)
- Zhejiang Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Sch Med, Hangzhou, Peoples R China
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- He, Di (author)
- Zhejiang Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Sch Med, Hangzhou, Peoples R China
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Fang, Aiping (author)
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- Bo, Yacong (author)
- Chinese Univ Hong Kong, Jockey Club Sch Publ Hlth & Primary Care, Hong Kong, Peoples R China
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- Song, Peige (author)
- Zhejiang Univ, Sch Publ Hlth, Hangzhou, Peoples R China.;Zhejiang Univ, Womens Hosp, Sch Med, Hangzhou, Peoples R China
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- Bogaert, Debby (author)
- Univ Edinburgh, Ctr Inflammat Res, Edinburgh, Midlothian, Scotland
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- Tsilidis, Kostas (author)
- Imperial Coll London, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England.;Univ Ioannina, Dept Hyg & Epidemiol, Sch Med, Ioannina, Greece
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- Larsson, Susanna C. (author)
- Karolinska Institutet,Uppsala universitet,Medicinsk epidemiologi,Karolinska Inst, Inst Environm Med, Unit Cardiovasc & Nutrit Epidemiol, Stockholm, Sweden
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- Yu, Huanling (author)
- Capital Med Univ, Beijing Key Lab Environm Toxicol, Sch Publ Hlth, Dept Nutr & Food Hyg, Beijing, Peoples R China
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- Zhu, Huilian (author)
- Sun Yat Sen Univ, Sch Publ Hlth, Dept Nutr, Guangzhou, Peoples R China
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- Theodoratou, Evropi (author)
- Univ Edinburgh, Usher Inst, Ctr Global Hlth, Edinburgh, Midlothian, Scotland.;Univ Edinburgh, Med Res Council Inst Genet & Canc, Canc Res UK Edinburgh Ctr, Edinburgh, Midlothian, Scotland
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Zhu, Yimin (author)
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- Li, Xue (author)
- Zhejiang Univ, Sch Med, Dept Big Data Hlth Sci, Sch Publ Hlth,Ctr Clin Big Data & Analyt,Affiliat, Hangzhou, Peoples R China
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(creator_code:org_t)
- Oxford University Press, 2022
- 2022
- English.
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In: American Journal of Clinical Nutrition. - : Oxford University Press. - 0002-9165 .- 1938-3207. ; 116:1, s. 230-243
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Abstract
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- Background: Trimethylamine-N-oxide (TMAO) is a gut microbiota-derived metabolite produced from dietary nutrients. Many studies have discovered that circulating TMAO concentrations are linked to a wide range of health outcomes.Objectives: This study aimed to summarize health outcomes related to circulating TMAO concentrations.Methods: We searched the Embase. Medline, Web of Science, and Scopus databases from inception to 15 February, 2022 to identify and update meta-analyses examining the associations between 'TAO and multiple health outcomes. For each health outcome, we estimated the summary effect size. 95% prediction CI. between-study heterogeneity. evidence of small-study effects, and evidence of excess-significance bias. These metrics were used to evaluate the evidence credibility of the identified associations.Results: This umbrella review identified 24 meta-analyses that investigated the association between circulating 'TAO concentrations and health outcomes including all-cause mortality, cardiovascular diseases (CVDs), diabetes mellitus (DM), cancer. and renal function. We updated these meta-analyses by including a total of 82 individual studies on 18 unique health outcomes. Among them, 14 associations were nominally significant. After evidence credibility assessment, we found 6 (33%) associations (i.e., all-cause mortality, CVD mortality, major adverse cardiovascular events, hypertension. DM, and glomerular filtration rate) to present highly suggestive evidence.Conclusions: TMAO might be a novel biomarker related to human health conditions including all-cause mortality, hypertension. CVD, DM. cancer, and kidney function. Further studies are needed to investigate whether circulating 'MAO concentrations could be an intervention target for chronic disease.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
Keyword
- umbrella review
- updated meta-analyses
- trimethylamine-N-oxide
- TMAO
- all-cause mortality
- cardiovascular disease
- hypertension
- diabetes mellitus
Publication and Content Type
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- By the author/editor
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Li, Doudou
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Lu, Ying
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Yuan, Shuai
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Cai, Xiaxia
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He, Yuan
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Chen, Jie
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show more...
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Wu, Qiong
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He, Di
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Fang, Aiping
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Bo, Yacong
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Song, Peige
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Bogaert, Debby
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Tsilidis, Kostas
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Larsson, Susanna ...
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Yu, Huanling
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Zhu, Huilian
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Theodoratou, Evr ...
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Zhu, Yimin
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Li, Xue
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Nutrition and Di ...
- Articles in the publication
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American Journal ...
- By the university
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Uppsala University
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Karolinska Institutet