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Gut microbiota-derived metabolite trimethylamine-N-oxide and multiple health outcomes : an umbrella review and updated meta-analysis

Li, Doudou (author)
Zhejiang Univ, Sch Med, Dept Big Data Hlth Sci, Sch Publ Hlth,Ctr Clin Big Data & Analyt,Affiliat, Hangzhou, Peoples R China
Lu, Ying (author)
Zhejiang Univ, Sch Med, Dept Big Data Hlth Sci, Sch Publ Hlth,Ctr Clin Big Data & Analyt,Affiliat, Hangzhou, Peoples R China
Yuan, Shuai (author)
Karolinska Institutet
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Cai, Xiaxia (author)
Capital Med Univ, Beijing Key Lab Environm Toxicol, Sch Publ Hlth, Dept Nutr & Food Hyg, Beijing, Peoples R China
He, Yuan (author)
Natl Res Inst Hlth & Family Planning, Beijing, Peoples R China
Chen, Jie (author)
Zhejiang Univ, Sch Med, Dept Big Data Hlth Sci, Sch Publ Hlth,Ctr Clin Big Data & Analyt,Affiliat, Hangzhou, Peoples R China
Wu, Qiong (author)
Zhejiang Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Sch Med, Hangzhou, Peoples R China
He, Di (author)
Zhejiang Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Sch Med, Hangzhou, Peoples R China
Fang, Aiping (author)
Bo, Yacong (author)
Chinese Univ Hong Kong, Jockey Club Sch Publ Hlth & Primary Care, Hong Kong, Peoples R China
Song, Peige (author)
Zhejiang Univ, Sch Publ Hlth, Hangzhou, Peoples R China.;Zhejiang Univ, Womens Hosp, Sch Med, Hangzhou, Peoples R China
Bogaert, Debby (author)
Univ Edinburgh, Ctr Inflammat Res, Edinburgh, Midlothian, Scotland
Tsilidis, Kostas (author)
Imperial Coll London, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England.;Univ Ioannina, Dept Hyg & Epidemiol, Sch Med, Ioannina, Greece
Larsson, Susanna C. (author)
Karolinska Institutet,Uppsala universitet,Medicinsk epidemiologi,Karolinska Inst, Inst Environm Med, Unit Cardiovasc & Nutrit Epidemiol, Stockholm, Sweden
Yu, Huanling (author)
Capital Med Univ, Beijing Key Lab Environm Toxicol, Sch Publ Hlth, Dept Nutr & Food Hyg, Beijing, Peoples R China
Zhu, Huilian (author)
Sun Yat Sen Univ, Sch Publ Hlth, Dept Nutr, Guangzhou, Peoples R China
Theodoratou, Evropi (author)
Univ Edinburgh, Usher Inst, Ctr Global Hlth, Edinburgh, Midlothian, Scotland.;Univ Edinburgh, Med Res Council Inst Genet & Canc, Canc Res UK Edinburgh Ctr, Edinburgh, Midlothian, Scotland
Zhu, Yimin (author)
Li, Xue (author)
Zhejiang Univ, Sch Med, Dept Big Data Hlth Sci, Sch Publ Hlth,Ctr Clin Big Data & Analyt,Affiliat, Hangzhou, Peoples R China
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 (creator_code:org_t)
Oxford University Press, 2022
2022
English.
In: American Journal of Clinical Nutrition. - : Oxford University Press. - 0002-9165 .- 1938-3207. ; 116:1, s. 230-243
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  • Research review (peer-reviewed)
Abstract Subject headings
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  • Background: Trimethylamine-N-oxide (TMAO) is a gut microbiota-derived metabolite produced from dietary nutrients. Many studies have discovered that circulating TMAO concentrations are linked to a wide range of health outcomes.Objectives: This study aimed to summarize health outcomes related to circulating TMAO concentrations.Methods: We searched the Embase. Medline, Web of Science, and Scopus databases from inception to 15 February, 2022 to identify and update meta-analyses examining the associations between 'TAO and multiple health outcomes. For each health outcome, we estimated the summary effect size. 95% prediction CI. between-study heterogeneity. evidence of small-study effects, and evidence of excess-significance bias. These metrics were used to evaluate the evidence credibility of the identified associations.Results: This umbrella review identified 24 meta-analyses that investigated the association between circulating 'TAO concentrations and health outcomes including all-cause mortality, cardiovascular diseases (CVDs), diabetes mellitus (DM), cancer. and renal function. We updated these meta-analyses by including a total of 82 individual studies on 18 unique health outcomes. Among them, 14 associations were nominally significant. After evidence credibility assessment, we found 6 (33%) associations (i.e., all-cause mortality, CVD mortality, major adverse cardiovascular events, hypertension. DM, and glomerular filtration rate) to present highly suggestive evidence.Conclusions: TMAO might be a novel biomarker related to human health conditions including all-cause mortality, hypertension. CVD, DM. cancer, and kidney function. Further studies are needed to investigate whether circulating 'MAO concentrations could be an intervention target for chronic disease.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Hälsovetenskap -- Näringslära (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Health Sciences -- Nutrition and Dietetics (hsv//eng)

Keyword

umbrella review
updated meta-analyses
trimethylamine-N-oxide
TMAO
all-cause mortality
cardiovascular disease
hypertension
diabetes mellitus

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