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  • Vergaro, GiuseppeFdn Toscana Gabrieie Monasterio, Scuola Super St Anna, Inst Life Sci, Via Giuseppe Moruzzi 1, I-56124 Pisa, Italy.;Fdn Toscana Gabrieie Monasterio, Div Cardiol & Cardiovasc Med, Via Giuseppe Moruzzi 1, I-56124 Pisa, Italy. (author)

Circulating levels and prognostic cut-offs of sST2, hs-cTnT, and NT-proBNP in women vs. men with chronic heart failure

  • Article/chapterEnglish2022

Publisher, publication year, extent ...

  • 2022-05-05
  • John Wiley & Sons,2022
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-485911
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-485911URI
  • https://doi.org/10.1002/ehf2.13883DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Aims To define plasma concentrations, determinants, and optimal prognostic cut-offs of soluble suppression of tumorigenesis-2 (sST2), high-sensitivity cardiac troponin T (hs-cTnT), and N-terminal pro-B-type natriuretic peptide (NT-proBNP) in women and men with chronic heart failure (HF). Methods and results Individual data of patients from the Biomarkers In Heart Failure Outpatient Study (BIOS) Consortium with sST2, hs-cTnT, and NT-proBNP measured were analysed. The primary endpoint was a composite of 1 year cardiovascular death and HF hospitalization. The secondary endpoints were 5 year cardiovascular and all-cause death. The cohort included 4540 patients (age 67 +/- 12 years, left ventricular ejection fraction 33 +/- 13%, 1111 women, 25%). Women showed lower sST2 (24 vs. 27 ng/mL, P < 0.001) and hs-cTnT level (15 vs. 20 ng/L, P < 0.001), and similar concentrations of NT-proBNP (1540 vs. 1505 ng/L, P = 0.408). Although the three biomarkers were confirmed as independent predictors of outcome in both sexes, the optimal prognostic cut-off was lower in women for sST2 (28 vs. 31 ng/mL) and hs-cTnT (22 vs. 25 ng/L), while NT-proBNP cut-off was higher in women (2339 ng/L vs. 2145 ng/L). The use of sex-specific cut-offs improved risk prediction compared with the use of previously standardized prognostic cut-offs and allowed to reclassify the risk of many patients, to a greater extent in women than men, and for hs-cTnT than sST2 or NT-proBNP. Specifically, up to 18% men and up to 57% women were reclassified, by using the sex-specific cut-off of hs-cTnT for the endpoint of 5 year cardiovascular death. Conclusions In patients with chronic HF, concentrations of sST2 and hs-cTnT, but not of NT-proBNP, are lower in women. Lower sST2 and hs-cTnT and higher NT-proBNP cut-offs for risk stratification could be used in women.

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  • Gentile, FrancescoPisa Univ Hosp, Cardiol Div, Pisa, Italy. (author)
  • Aimo, AlbertoFdn Toscana Gabrieie Monasterio, Scuola Super St Anna, Inst Life Sci, Via Giuseppe Moruzzi 1, I-56124 Pisa, Italy.;Fdn Toscana Gabrieie Monasterio, Div Cardiol & Cardiovasc Med, Via Giuseppe Moruzzi 1, I-56124 Pisa, Italy. (author)
  • Januzzi, James L.Massachusetts Gen Hosp, Boston, MA 02114 USA.;Baim Inst Clin Res, Boston, MA USA. (author)
  • Richards, A. MarkUniv Otago, Dept Med, Dunedin, New Zealand.;Natl Univ Singapore, Natl Univ Heart Ctr, Singapore, Singapore. (author)
  • Lam, Carolyn S. P.Natl Heart Ctr Singapore, Singapore, Singapore.;Duke Natl Univ Singapore, Singapore, Singapore. (author)
  • Boer, Rudolf A.Univ Med Ctr Groningen, Groningen, Netherlands. (author)
  • Meems, Laura M. G.Univ Med Ctr Groningen, Groningen, Netherlands. (author)
  • Latini, RobertoIst Ric Farmacol Mario Negri IRCCS, Milan, Italy. (author)
  • Staszewsky, LidiaIst Ric Farmacol Mario Negri IRCCS, Milan, Italy. (author)
  • Anand, Inder S.Univ Minnesota, Med Ctr, Minneapolis, MN 55455 USA.;VA Med Ctr, Minneapolis, MN USA. (author)
  • Cohn, Jay N.Univ Minnesota, Med Ctr, Minneapolis, MN 55455 USA. (author)
  • Ueland, ThorOslo Univ Hosp, Oslo, Norway.;Oslo Univ Hosp, Rikshosp, Oslo, Norway.;Univ Oslo, Inst Clin Med, Oslo, Norway.;Univ Tromso, KG Jebsen Thrombosis Res & Expertise Ctr, Tromso, Norway. (author)
  • Gullestad, LarsUniv Oslo, KG Jebsen Ctr Cardiac Res, Oslo, Norway.;Oslo Univ Hosp, Ctr Heart Failure Res, Oslo, Norway. (author)
  • Aukrust, PalOslo Univ Hosp, Rikshosp, Oslo, Norway. (author)
  • Rocca, Hans-Peter Brunner-LaMaastricht Univ, Med Ctr, Maastricht, Netherlands. (author)
  • Bayes-Genis, AntoniHosp Univ Germans Trias I Pujol, Badalona, Barcelona, Spain.;Inst Salud Carlos III, CIBER Cardiovasc, Madrid, Spain. (author)
  • Lupon, JosepHosp Univ Germans Trias I Pujol, Badalona, Barcelona, Spain.;Inst Salud Carlos III, CIBER Cardiovasc, Madrid, Spain. (author)
  • Yoshihisa, AkiomiFukushima Med Univ, Dept Internal Med 1, Fukushima, Japan. (author)
  • Takeishi, YasuchikaFukushima Med Univ, Dept Internal Med 1, Fukushima, Japan. (author)
  • Egstrup, MichaelRigshosp, Copenhagen Univ Hosp, Copenhagen, Denmark. (author)
  • Gustafsson, IdaRigshosp, Copenhagen Univ Hosp, Copenhagen, Denmark. (author)
  • Gaggin, Hanna K.Massachusetts Gen Hosp, Heart Ctr, Boston, MA 02114 USA.;Harvard Med Sch, Boston, MA 02115 USA. (author)
  • Eggers, Kai M.,1962-Uppsala universitet,Kardiologi(Swepub:uu)kaieg561 (author)
  • Huber, KurtWilhelminenspital Stadt Wien, Vienna, Austria.;Sigmund Freud Univ, Med Sch, Vienna, Austria. (author)
  • Gamble, Greg D.Univ Auckland, Fac Med & Hlth Sci, Auckland, New Zealand. (author)
  • Ling, Lieng H.Natl Univ Heart Ctr, Dept Cardiol, Singapore, Singapore.;Natl Univ Singapore, Singapore, Singapore. (author)
  • Leong, Kui Toh GerardChangi Gen Hosp, Singapore, Singapore. (author)
  • Yeo, Poh Shuah DanielTan Tock Seng Hosp, Singapore, Singapore. (author)
  • Ong, Hean YeeKhoo Teck Puat Hosp, Singapore, Singapore. (author)
  • Jaufeerally, FazlurSingapore Gen Hosp, Singapore, Singapore. (author)
  • Ng, Tze P.Natl Univ Heart Ctr, Dept Cardiol, Singapore, Singapore.;Natl Univ Singapore, Singapore, Singapore. (author)
  • Troughton, RichardUniv Otago, Dept Med, Dunedin, New Zealand.;Natl Univ Singapore, Natl Univ Heart Ctr, Singapore, Singapore. (author)
  • Doughty, Robert N.Univ Auckland, Fac Med & Hlth Sci, Auckland, New Zealand. (author)
  • Devlin, GerryGisborne Hosp, Gisborne, New Zealand. (author)
  • Lund, MayannaMiddlemore Hosp, Auckland, New Zealand. (author)
  • Giannoni, AlbertoFdn Toscana Gabrieie Monasterio, Scuola Super St Anna, Inst Life Sci, Via Giuseppe Moruzzi 1, I-56124 Pisa, Italy.;Fdn Toscana Gabrieie Monasterio, Div Cardiol & Cardiovasc Med, Via Giuseppe Moruzzi 1, I-56124 Pisa, Italy. (author)
  • Passino, ClaudioFdn Toscana Gabrieie Monasterio, Scuola Super St Anna, Inst Life Sci, Via Giuseppe Moruzzi 1, I-56124 Pisa, Italy.;Fdn Toscana Gabrieie Monasterio, Div Cardiol & Cardiovasc Med, Via Giuseppe Moruzzi 1, I-56124 Pisa, Italy. (author)
  • Emdin, MicheleFdn Toscana Gabrieie Monasterio, Scuola Super St Anna, Inst Life Sci, Via Giuseppe Moruzzi 1, I-56124 Pisa, Italy.;Fdn Toscana Gabrieie Monasterio, Div Cardiol & Cardiovasc Med, Via Giuseppe Moruzzi 1, I-56124 Pisa, Italy. (author)
  • Fdn Toscana Gabrieie Monasterio, Scuola Super St Anna, Inst Life Sci, Via Giuseppe Moruzzi 1, I-56124 Pisa, Italy.;Fdn Toscana Gabrieie Monasterio, Div Cardiol & Cardiovasc Med, Via Giuseppe Moruzzi 1, I-56124 Pisa, Italy.Pisa Univ Hosp, Cardiol Div, Pisa, Italy. (creator_code:org_t)

Related titles

  • In:ESC Heart Failure: John Wiley & Sons9:4, s. 2084-20952055-5822

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