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Search: onr:"swepub:oai:DiVA.org:uu-485917" > Anal cancer in Swed...

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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004328naa a2200445 4500
001oai:DiVA.org:uu-485917
003SwePub
008221017s2022 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4859172 URI
0247 a https://doi.org/10.1080/0284186X.2022.20480692 DOI
040 a (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Johnsson, Andersu Skane Univ Hosp, Dept Oncol, S-22185 Lund, Sweden.4 aut
2451 0a Anal cancer in Sweden 2015-2019. Implementation of guidelines, structural changes, national registry and early results
264 1b Taylor & Francis Group,c 2022
338 a print2 rdacarrier
520 a Background Squamous cell cancer of the anus is an uncommon malignancy, usually caused by human papilloma virus (HPV). Chemoradiotherapy (CRT) is the recommended treatment in localized disease with cure rates of 60-80%. Local failures should be considered for salvage surgery. With the purpose of improving and equalizing the anal cancer care in Sweden, a number of actions were taken between 2015 and 2017. The aim of this study was to describe the implementation of guidelines and organizational changes and to present early results from the first 5 years of the Swedish anal cancer registry (SACR). Methods The following were implemented: (1) the first national care program with treatment guidelines, (2) standardized care process, (3) centralization of CRT to four centers and salvage surgery to two centers, (4) weekly national multidisciplinary team meetings where all new cases are discussed, (5) the Swedish anal cancer registry (SACR) was started in 2015. Results The SACR included 912 patients with a diagnosis of anal cancer from 2015 to 2019, reaching a national coverage of 95%. We could show that guidelines issued in 2017 regarding staging procedures and radiotherapy dose modifications were rapidly implemented. At baseline 52% of patients had lymph node metastases and 9% had distant metastases. Out of all patients in the SACR 89% were treated with curative intent, most of them with CRT, after which 92% achieved a local complete remission and the estimated overall 3-year survival was 85%. Conclusions This is the first report from the SACR, demonstrating rapid nation-wide implementation of guidelines and apparently good treatment outcome in patients with anal cancer in Sweden. The SACR will hopefully be a valuable source for future research.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
653 a Anal cancer
653 a guidelines
653 a chemoradiotherapy
7001 a Norman, Davidu Reg Canc Ctr North, Umeå, Sweden.4 aut
7001 a Angenete, Evau Univ Gothenburg, Sahlgrenska Acad, Sahlgrenska Univ Hosp, Dept Surg, Gothenburg, Sweden.;Univ Gothenburg, Sahlgrenska Acad, Inst Clin Sci, Gothenburg, Sweden.4 aut
7001 a Cavalli-Björkman, Nina,d 1970-u Uppsala universitet,Experimentell och klinisk onkologi4 aut0 (Swepub:uu)ninca468
7001 a Lagerbäck, Ceciliau Soder Sjukhuset, Dept Oncol, Stockholm, Sweden.4 aut
7001 a Leon, Otiliau Skane Univ Hosp, Dept Oncol, S-22185 Lund, Sweden.4 aut
7001 a Lindh, Birgittau Univ Hosp Northern Sweden, Dept Oncol, Umeå, Sweden.4 aut
7001 a Lydrup, Marie-Louiseu Skane Univ Hosp, Dept Surg, Malmö, Sweden.4 aut
7001 a Nilsson, Martin P.u Skane Univ Hosp, Dept Oncol, S-22185 Lund, Sweden.4 aut
7001 a Perman, Matsu Sahlgrens Univ Hosp, Dept Oncol, Gothenburg, Sweden.4 aut
7001 a Radu, Calin,d 1969-u Uppsala universitet,Experimentell och klinisk onkologi4 aut0 (Swepub:uu)calra471
7001 a Zackrisson, Björnu Univ Hosp Northern Sweden, Dept Oncol, Umeå, Sweden.4 aut
7102 a Skane Univ Hosp, Dept Oncol, S-22185 Lund, Sweden.b Reg Canc Ctr North, Umeå, Sweden.4 org
7730 t Acta Oncologicad : Taylor & Francis Groupg 61:5, s. 575-582q 61:5<575-582x 0284-186Xx 1651-226X
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-485917
8564 8u https://doi.org/10.1080/0284186X.2022.2048069

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