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Allergies and COVID-19 vaccines : An ENDA/EAACI Position paper

Barbaud, Annick (author)
Sorbonne Univ, INSERM, Inst Pierre Louis Epidemiol & Sante Publ, Hop Tenon,AP HP,Dept Dermatol & Allergol, F-75020 Paris, France
Garvey, Lene Heise (author)
Copenhagen Univ Hosp Gentofte, Allergy Clin, Copenhagen, Denmark.;Univ Copenhagen, Dept Clin Med, Copenhagen, Denmark
Arcolaci, Alessandra (author)
Univ Hosp Verona, Immunol Unit, Policlin GB Rossi, Verona, Italy
show more...
Brockow, Knut (author)
Tech Univ Munich, Fac Med, Dept Dermatol & Allergy Biederstein, Munich, Germany
Mori, Francesca (author)
Meyer Childrens Univ Hosp, Dept Pediat, Allergy Unit, Florence, Italy
Mayorga, Cristobalina (author)
Hosp Reg Univ Malaga, Allergy Clin Unit, Inst Invest Biomed Malaga IBIMA, ARADyAL, Malaga, Spain
Bonadonna, Patrizia (author)
Verona Univ Hosp, Allergy Unit, Verona, Italy
Atanaskovic-Markovic, Marina (author)
Univ Belgrade, Univ Childrens Hosp, Fac Med, Belgrade, Serbia
Moral, Luis (author)
Alicante Univ Gen Hosp, Alicante Inst Hlth & Biomed Res ISABIAL, Pediat Allergy & Resp Unit, Alicante, Spain
Zanoni, Giovanna (author)
Azienda Osped Univ Integrata Verona, Immunol Unit, Policlin GB Rossi, Verona, Italy
Pagani, Mauro (author)
ASST Mantova, Med Dept, Med Ward Mantova Hosp, Mantua, Italy
Soria, Angele (author)
Sorbonne Univ, INSERM 1135 Cimi Paris, Hop Tenon, Assistance Publ Hop Paris,Dept Dermatol & Allergo, Paris, France
Jost, Maja (author)
Univ Clin Resp & Allerg Dis Golnik, Golnik, Slovenia
Caubet, Jean-Christoph (author)
Univ Hosp Geneva, Dept Women Children Teenagers, Geneva, Switzerland
Carmo, Abreu (author)
Ctr Hosp Tras Os Montes & Alto Douro, Ctr Hosp Baixo Vouga, Allergy & Clin Immunol Unit, Vila Real & Allergy & Clin Immunol Unit, Aveiro, Portugal
Mona, Al-Ahmad (author)
Kuwait Univ, Fac Med, Microbiol Dept, Kuwait, Kuwait
Alvarez-Perea, Alberto (author)
Hosp Gen Univ Gregorio Maranon, Allergy Dept, Madrid, Spain
Bavbek, Sevim (author)
Ankara Univ, Sch Med, Dept Pulm Dis, Div Allergy,FAAAI, Ankara, Turkey
Benedetta, Biagioni (author)
IRCCS Azienda Osped Univ Bologna, Div Internal Med Hepatobiliary & Immunoallerg Dis, Bologna, Italy
Bilo, M. Beatrice (author)
Univ Politecn Marche, Dept Clin & Mol Sci, Ancona, Italy.;Univ Hosp Osped Riuniti Ancona, Allergy Unit, Dept Internal Med, Ancona, Italy
Blanca-Lopez, Natalia (author)
Infanta Leonor Univ Hosp, Madrid, Spain
Bogas, Herrera Gador (author)
Hosp Reg Univ Malaga HRUM, Inst Invest Biomed Malaga IBIMA, Allergy Res Grp, Malaga, Spain.;Hosp Reg Univ Malaga HRUM, Allergy Unit, Malaga, Spain
Buonomo, Alessandro (author)
Fdn Policlin Gemelli IRCCS Largo Gemelli, Allergy Unit, Rome, Italy
Calogiuri, Gianfranco (author)
Hosp Vito Fazzi, Lecce, Italy
Carli, Giulia (author)
Azienda USL Toscana Ctr, Osped S Stefano, SOS Allergol & Immunol, Prato, Italy
Cernadas, Josefina (author)
Ctr Hosp Univ S Joao, Allergy & Clin Immunol Dept, Porto, Portugal.;Hosp Lusiadas, Allergy Unit, Porto, Portugal
Cortellini, Gabriele (author)
Azienda Sanitaria Romagna, Rimini Hosp, Allergy Unit, Dept Internal Med, Rimini, Italy
Celik, Gulfem (author)
Ankara Univ, Dept Chest Dis, Div Immunol & Allergy, Sch Med,Cebeci Hosp, Ankara, Turkey
Demir, Semra (author)
Istanbul Univ, Istanbul Fac Med Internal Med Immunol & Allerg Di, Istanbul, Turkey
Dona, Inmaculada (author)
Hosp Reg Univ Malaga, Inst Invest Biomed Malaga IBIMA, Allergy Unit, Allergy Res Grp, Plaza Hosp Civil S-N, Malaga, Spain
Dursun, Adile Berna (author)
Mem Ankara Hosp, Dept Adult Allergy, Ankara, Turkey
Eberlein, Bernadette (author)
Tech Univ Munich, Fac Med, Dept Dermatol & Allergy Biederstein, Munich, Germany
Faria, Emilia (author)
Ctr Hosp & Univ Coimbra, Allergy & Clin Immunol Unit, Coimbra, Portugal
Fernandes, Bryan (author)
Barts Hlth NHS Trust, St Bartholomews Hosp, London, England
Garcez, Tomaz (author)
Manchester Univ NHS Fdn Trust, Immunol Dept, Manchester, Lancs, England
Garcia-Nunez, Ignacio (author)
Hosp Quironsalud Cordoba, Cordoba, Spain
Gawlik, Radoslaw (author)
Med Univ Silesia, Dept Internal Dis Allergol & Clin Immunol, Katowice, Poland
Gelincik, Asli (author)
Istanbul Univ, Istanbul Fac Med Internal Med Immunol & Allerg Di, Istanbul, Turkey
Gomes, Eva (author)
Ctr Hosp Univ Porto, Allergy Dept, Porto, Portugal
Gooi, Jimmy H. C. (author)
Kings Coll Hosp London, Dept Clin Immunol, London, England
Grosber, Martine (author)
Vrije Univ Brussel, Univ Ziekenhuis, Dept Dermatol, Brussels, Belgium
Gulen, Theo (author)
Karolinska Institutet
Hacard, Florence (author)
Ctr Hosp Lyon Sud, Allergol & Clin Immunol Dept, Pierre Benite, France
Hoarau, Cyrille (author)
CHR Tours, Serv Transversal Allergol & Immunol Clin, Tours, France
Janson, Christer (author)
Uppsala universitet,Klinisk fysiologi
Johnston, Sebastian L. (author)
Imperial Coll London, Natl Heart & Lung Inst, London, England
Joerg, Lukas (author)
Univ Bern, Bern Univ Hosp, Dept Pneumol, Div Allergol & Clin Immunol,Inselspital, Bern, Switzerland
Ozdemir, Secil Kepil (author)
Chest Dis & Surg Training & Res Hosp, Dept Chest Dis, Div Allergy & Immunol, Izmir, Turkey
Klimek, Ludger (author)
Ctr Rhinol & Allergol, Wiesbaden, Germany
Kosnik, Mitja (author)
Univ Clin Golnik, Golnik, Slovenia
Kowalski, Marek L. (author)
Med Univ Lodz, Dept Immunol & Allergy, Lodz, Poland
Kuyucu, Semanur (author)
Mersin Univ, Fac Med, Dept Pediat Allergy & Immunol, Mersin, Turkey
Kvedariene, Violeta (author)
Vilnius Univ, Fac Med, Dept Pathol, Inst Biomed Sci,Clin Chest Dis, Vilnius, Lithuania
Laguna, Jose Julio (author)
Alfonso X El Sabio Univ, Hosp Cent Cruz Roja, Fac Med, Allergy Unit,Allergoanaesthesia Unit, Madrid, Spain
Lombardo, Carla (author)
Allergy Unit, Trento, Italy
Marinho, Susana (author)
Manchester Univ NHS Fdn Trust, Wythenshawe Hosp, Allergy Ctr, Manchester, Lancs, England.;Univ Manchester, Manchester, Lancs, England
Merk, Hans (author)
Meucci, Elisa (author)
Osped San Giovanni di Dio, Azienda USL Toscana Ctr, SOS Allergol & Immunol Clin, Florence, Italy
Morisset, Martine (author)
Angers Univ Hosp, Allergy Unit, Angers, France
Munoz-Cano, Rosa (author)
Murzilli, Francesco (author)
SS Filippo & Nicola, Allergy Unit, Avezzano, Italy
Nakonechna, Alla (author)
Univ Liverpool, Lancashire Teaching Hosp NHS Fdn Trust, Royal Preston Hosp, Allergy & Clin Immunol Dept, Liverpool, Merseyside, England
Popescu, Florin-Dan (author)
Carol Davila Univ Med & Pharm, Nicolae Malaxa Clin Hosp, Dept Allergol, Bucharest, Romania
Porebski, Grzegorz (author)
Jagiellonian Univ Med Coll, Dept Clin & Environm Allergol, Krakow, Poland
Radice, Anna (author)
Osped San Giovanni di Dio, Azienda USL Toscana Ctr, SOS Allergol & Immunol Clin, Florence, Italy
Regateiro, Frederico S. (author)
Ctr Hosp & Univ Coimbra, Allergy & Clin Immunol Unit, Coimbra, Portugal.;Univ Coimbra, Fac Med, Inst Immunol, Coimbra, Portugal.;Univ Coimbra, Fac Med, ICBR Coimbra Inst Clin & Biomed Res, CIBB, Coimbra, Portugal
Rockmann, Heike (author)
Univ Med Ctr Utrecht, Dept Dermatol, Heidelberglaan 100, Utrecht, Netherlands
Romano, Antonino (author)
Oasi Res Inst IRCCS, Troina, Italy
Sargur, Ravishankar (author)
Sheffield Teaching Hosp NHS Fdn Trust, Northern Gen Hosp, Clin Immunol & Allergy Unit, Sheffield, S Yorkshire, England
Sastre, Joaquin (author)
Univ Autonoma Madrid, Inst Salud Carlos 3, Allergy Dept, CIBERES,Fdn Jimenez Diaz, Madrid, Spain
Hofmeier, Kathrin Scherer (author)
Cantonal Hosp Aarau, Dept Dermatol & Allergy, Aarau, Switzerland
Sedlackova, Lenka (author)
Gennet Sro, Allergy & Clin Immunol, Prague, Czech Republic
Sobotkova, Marta (author)
Motol Univ Hosp, Dept Immunol, Prague, Czech Republic.;Charles Univ Prague, Fac Med 2, Prague, Czech Republic
Terreehorst, Ingrid (author)
AUMC, Dept ENT, Amsterdam, Netherlands
Treudler, Regina (author)
Univ Med Leipzig, Dept Dermatol Venerol & Allergol, Leipzig, Germany
Walusiak-Skorupa, Jolanta (author)
Nofer Inst Occupat Med, Dept Occupat Dis & Environm Hlth, Lodz, Poland
Wedi, Bettina (author)
Hannover Med Sch, Comprehens Allergy Ctr, Dept Dermatol & Allergy, OE6600, Hannover, Germany
Wohrl, Stefan (author)
Floridsdorf Allergy Ctr FAZ, Vienna, Austria
Zidarn, Mihael (author)
Univ Clin Resp & Allerg Dis Golnik, Golnik, Slovenia.;Univ Ljubljana, Fac Med, Internal Med, Ljubljana, Slovenia
Zuberbier, Torsten (author)
Charite Univ Med Berlin, Klin Dermatol, Berlin, Germany
Agache, Ioana (author)
Transylvania Univ, Fac Med, Brasov, Spain
Torres, Maria J. (author)
Reg Univ Hosp Malaga, Allergy Unit, IBIMA UMA ARADyAL, Malaga, Spain
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Sorbonne Univ, INSERM, Inst Pierre Louis Epidemiol & Sante Publ, Hop Tenon,AP HP,Dept Dermatol & Allergol, F-75020 Paris, France Copenhagen Univ Hosp Gentofte, Allergy Clin, Copenhagen, Denmark;Univ Copenhagen, Dept Clin Med, Copenhagen, Denmark (creator_code:org_t)
2022-03-05
2022
English.
In: Allergy. European Journal of Allergy and Clinical Immunology. - : John Wiley & Sons. - 0105-4538 .- 1398-9995. ; 77:8, s. 2292-2312
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Background Anaphylaxis, which is rare, has been reported after COVID-19 vaccination, but its management is not standardized.Method Members of the European Network for Drug Allergy and the European Academy of Allergy and Clinical Immunology interested in drug allergy participated in an online questionnaire on pre-vaccination screening and management of allergic reactions to COVID-19 vaccines, and literature was analysed.Results No death due to anaphylaxis to COVID-19 vaccines has been confirmed in scientific literature. Potential allergens, polyethylene glycol (PEG), polysorbate and tromethamine are excipients. The authors propose allergy evaluation of persons with the following histories: 1-anaphylaxis to injectable drug or vaccine containing PEG or derivatives; 2-anaphylaxis to oral/topical PEG containing products; 3-recurrent anaphylaxis of unknown cause; 4-suspected or confirmed allergy to any mRNA vaccine; and 5-confirmed allergy to PEG or derivatives. We recommend a prick-to-prick skin test with the left-over solution in the suspected vaccine vial to avoid waste. Prick test panel should include PEG 4000 or 3500, PEG 2000 and polysorbate 80. The value of in vitro test is arguable.Conclusions These recommendations will lead to a better knowledge of the management and mechanisms involved in anaphylaxis to COVID-19 vaccines and enable more people with history of allergy to be vaccinated.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)

Keyword

allergy test
anaphylaxis
COVID-19 vaccine
mRNA vaccines
risk assessment

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ref (subject category)
art (subject category)

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Barbaud, Annick
Garvey, Lene Hei ...
Arcolaci, Alessa ...
Brockow, Knut
Mori, Francesca
Mayorga, Cristob ...
show more...
Bonadonna, Patri ...
Atanaskovic-Mark ...
Moral, Luis
Zanoni, Giovanna
Pagani, Mauro
Soria, Angele
Jost, Maja
Caubet, Jean-Chr ...
Carmo, Abreu
Mona, Al-Ahmad
Alvarez-Perea, A ...
Bavbek, Sevim
Benedetta, Biagi ...
Bilo, M. Beatric ...
Blanca-Lopez, Na ...
Bogas, Herrera G ...
Buonomo, Alessan ...
Calogiuri, Gianf ...
Carli, Giulia
Cernadas, Josefi ...
Cortellini, Gabr ...
Celik, Gulfem
Demir, Semra
Dona, Inmaculada
Dursun, Adile Be ...
Eberlein, Bernad ...
Faria, Emilia
Fernandes, Bryan
Garcez, Tomaz
Garcia-Nunez, Ig ...
Gawlik, Radoslaw
Gelincik, Asli
Gomes, Eva
Gooi, Jimmy H. C ...
Grosber, Martine
Gulen, Theo
Hacard, Florence
Hoarau, Cyrille
Janson, Christer
Johnston, Sebast ...
Joerg, Lukas
Ozdemir, Secil K ...
Klimek, Ludger
Kosnik, Mitja
Kowalski, Marek ...
Kuyucu, Semanur
Kvedariene, Viol ...
Laguna, Jose Jul ...
Lombardo, Carla
Marinho, Susana
Merk, Hans
Meucci, Elisa
Morisset, Martin ...
Munoz-Cano, Rosa
Murzilli, France ...
Nakonechna, Alla
Popescu, Florin- ...
Porebski, Grzego ...
Radice, Anna
Regateiro, Frede ...
Rockmann, Heike
Romano, Antonino
Sargur, Ravishan ...
Sastre, Joaquin
Hofmeier, Kathri ...
Sedlackova, Lenk ...
Sobotkova, Marta
Terreehorst, Ing ...
Treudler, Regina
Walusiak-Skorupa ...
Wedi, Bettina
Wohrl, Stefan
Zidarn, Mihael
Zuberbier, Torst ...
Agache, Ioana
Torres, Maria J.
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MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Clinical Medicin ...
and Respiratory Medi ...
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Health Sciences
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Uppsala University
Karolinska Institutet

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