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  • Ali, AhmedLeiden Univ, Leiden Acad Ctr Drug Res, Gorlaeus Bldg Einsteinweg 55, NL-2333 CC Leiden, Netherlands. (author)

Single cell metabolism : current and future trends

  • Article/chapterEnglish2022

Publisher, publication year, extent ...

  • 2022-10-01
  • Springer,2022
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-486672
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-486672URI
  • https://doi.org/10.1007/s11306-022-01934-3DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:for swepub-publicationtype

Notes

  • Single cell metabolomics is an emerging and rapidly developing field that complements developments in single cell analysis by genomics and proteomics. Major goals include mapping and quantifying the metabolome in sufficient detail to provide useful information about cellular function in highly heterogeneous systems such as tissue, ultimately with spatial resolution at the individual cell level. The chemical diversity and dynamic range of metabolites poses particular challenges for detection, identification and quantification. In this review we discuss both significant technical issues of measurement and interpretation, and progress toward addressing them, with recent examples from diverse biological systems. We provide a framework for further directions aimed at improving workflow and robustness so that such analyses may become commonly applied, especially in combination with metabolic imaging and single cell transcriptomics and proteomics.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Davidson, ShawnPrinceton Univ, Lewis Sigler Inst Integrat Genom, Princeton, NJ 08544 USA. (author)
  • Fraenkel, ErnestMIT, Dept Biol Engn, 77 Massachusetts Ave, Cambridge, MA 02139 USA.;MIT, Computat & Syst Biol Program, 77 Massachusetts Ave, Cambridge, MA 02139 USA. (author)
  • Gilmore, IanNatl Phys Lab, Teddington TW11 0LW, Middx, England. (author)
  • Hankemeier, ThomasLeiden Univ, Leiden Acad Ctr Drug Res, Room GW4 07,Gorlaeus Bldg,Einsteinweg 55, NL-2333 CC Leiden, Netherlands. (author)
  • Kirwan, Jennifer A.Charite Univ Med Berlin, Berlin Inst Hlth, Metabol Platform, Translat Res Unit, Anna Louisa Karsch Str 2, D-10178 Berlin, Germany. (author)
  • Lane, Andrew N.Univ Kentucky, Dept Toxicol & Canc Biol, 789 S Limestone St, Lexington, KY 40536 USA.;Univ Kentucky, Ctr Environm & Syst Biochem, 789 S Limestone St, Lexington, KY 40536 USA. (author)
  • Lanekoff, Ingela,Assoc. Prof.1975-Uppsala universitet,Analytisk kemi(Swepub:uu)ingla753 (author)
  • Larion, MioaraNCI, Ctr Canc Res, Bldg 37,Room 1136A, Bethesda, MD 20892 USA. (author)
  • McCall, Laura-IsobelUniv Oklahoma, Dept Chem & Biochem, Dept Microbiol & Plant Biol, Labs Mol Anthropol & Microbiome Res, 101 Stephenson Pkwy,room 3750, Norman, OK 73019 USA. (author)
  • Murphy, MichaelMIT, Dept Biol Engn, Dept Elect Engn & Comp Sci, 77 Massachusetts Ave, Cambridge, MA 02139 USA.;MIT, Computat & Syst Biol Program, 77 Massachusetts Ave, Cambridge, MA 02139 USA. (author)
  • Sweedler, Jonathan V.Univ Illinois, Dept Chem, 505 South Mathews Ave, Urbana, IL 61801 USA.;Univ Illinois, Beckman Inst, 505 South Mathews Ave, Urbana, IL 61801 USA. (author)
  • Zhu, CaigangUniv Kentucky, Dept Biomed Engn, Lexington, KY 40536 USA. (author)
  • Leiden Univ, Leiden Acad Ctr Drug Res, Gorlaeus Bldg Einsteinweg 55, NL-2333 CC Leiden, Netherlands.Princeton Univ, Lewis Sigler Inst Integrat Genom, Princeton, NJ 08544 USA. (creator_code:org_t)

Related titles

  • In:Metabolomics: Springer18:101573-38821573-3890

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