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Unlocking the human...
Unlocking the human inner ear for therapeutic intervention
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- Li, Hao, 1984- (author)
- Uppsala universitet,Öron-, näs- och halssjukdomar
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- Agrawal, Sumit (author)
- Western Univ, Dept Otolaryngol Head & Neck Surg, London, ON, Canada.;Western Univ, Dept Med Biophys, London, ON, Canada.;Western Univ, Dept Elect & Comp Engn, London, ON, Canada.;Western Univ, Sch Biomed Engn, London, ON, Canada.
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- Rohani, Seyed Alireza (author)
- Western Univ, Dept Otolaryngol Head & Neck Surg, London, ON, Canada.
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- Zhu, Ning (author)
- Canadian Light Source, Saskatoon, SK, Canada.;Univ Saskatchewan, Coll Engn, Dept Chem & Biol Engn, Saskatoon, SK, Canada.
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- Cacciabue, Daniela, I (author)
- Univ Sheffield, Sch Biosci Ctr Stem Cell Biol, Sheffield, S Yorkshire, England.
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- Rivolta, Marcelo N. (author)
- Univ Sheffield, Sch Biosci Ctr Stem Cell Biol, Sheffield, S Yorkshire, England.
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- Hartley, Douglas E. H. (author)
- Natl Inst Hlth Res NIHR, Nottingham Biomed Res Ctr, Nottingham, England.;Nottingham Univ Hosp NHS Trust, Queens Med Ctr, Nottingham, England.;Univ Nottingham, Otol & Hearing Grp, Div Clin Neurosci, Sch Med, Nottingham, England.
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- Jiang, Dan (author)
- Kings Coll London, Ctr Craniofacial & Regenerat Biol, London, England.;Guys & St Thomas NHS Fdn Trust, Hearing Implant Ctr, London, England.
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- Ladak, Hanif M. (author)
- Western Univ, Dept Otolaryngol Head & Neck Surg, London, ON, Canada.;Western Univ, Dept Med Biophys, London, ON, Canada.;Western Univ, Dept Elect & Comp Engn, London, ON, Canada.;Western Univ, Sch Biomed Engn, London, ON, Canada.
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- O'Donoghue, Gerard M. (author)
- Natl Inst Hlth Res NIHR, Nottingham Biomed Res Ctr, Nottingham, England.;Nottingham Univ Hosp NHS Trust, Queens Med Ctr, Nottingham, England.
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- Rask-Andersen, Helge (author)
- Uppsala universitet,Öron-, näs- och halssjukdomar
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(creator_code:org_t)
- 2022-11-08
- 2022
- English.
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In: Scientific Reports. - : Springer Nature. - 2045-2322. ; 12:1
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Abstract
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- The human inner ear contains minute three-dimensional neurosensory structures that are deeply embedded within the skull base, rendering them relatively inaccessible to regenerative therapies for hearing loss. Here we provide a detailed characterisation of the functional architecture of the space that hosts the cell bodies of the auditory nerve to make them safely accessible for the first time for therapeutic intervention. We used synchrotron phase-contrast imaging which offers the required microscopic soft-tissue contrast definition while simultaneously displaying precise bony anatomic detail. Using volume-rendering software we constructed highly accurate 3-dimensional representations of the inner ear. The cell bodies are arranged in a bony helical canal that spirals from the base of the cochlea to its apex; the canal volume is 1.6 mu L but with a diffusion potential of 15 mu L. Modelling data from 10 temporal bones enabled definition of a safe trajectory for therapeutic access while preserving the cochlea's internal architecture. We validated the approach through surgical simulation, anatomical dissection and micro-radiographic analysis. These findings will facilitate future clinical trials of novel therapeutic interventions to restore hearing.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Oto-rhino-laryngologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Otorhinolaryngology (hsv//eng)
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- ref (subject category)
- art (subject category)
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- By the author/editor
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Li, Hao, 1984-
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Agrawal, Sumit
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Rohani, Seyed Al ...
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Zhu, Ning
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Cacciabue, Danie ...
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Rivolta, Marcelo ...
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show more...
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Hartley, Douglas ...
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Jiang, Dan
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Ladak, Hanif M.
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O'Donoghue, Gera ...
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Rask-Andersen, H ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Otorhinolaryngol ...
- Articles in the publication
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Scientific Repor ...
- By the university
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Uppsala University