Bidirectional Association between Major Depressive Disorder and Gastroesophageal Reflux Disease: Mendelian Randomization Study

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Miao, YuyangTianjin Med Univ, Dept Geriatr, Gen Hosp, Tianjin 300052, Peoples R China.;Tianjin Geriatr Inst, Tianjin 300052, Peoples R China. (författare)

Bidirectional Association between Major Depressive Disorder and Gastroesophageal Reflux Disease : Mendelian Randomization Study

Artikel/kapitelEngelska2022

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2022-11-02
MDPI,2022
electronicrdacarrier

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LIBRIS-ID:oai:DiVA.org:uu-489358
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-489358URI
https://doi.org/10.3390/genes13112010DOI
http://kipublications.ki.se/Default.aspx?queryparsed=id:151151274URI

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Språk:engelska
Sammanfattning på:engelska

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Background: Observational research has found a bidirectional relationship between major depressive disorder and gastroesophageal reflux disease; however, the causal association of this relationship is undetermined. Aims: A bidirectional Mendelian randomization study was performed to explore the causal relationships between major depressive disorder and gastroesophageal reflux disease. Methods: For the instrumental variables of major depressive disorder and gastroesophageal reflux disease, 31 and 24 single-nucleotide polymorphisms without linkage disequilibrium (r(2) <= 0.001) were selected from relevant genome-wide association studies, respectively, at the genome-wide significance level (p <= 5 x 10(-8)). We sorted summary-level genetic data for major depressive disorder, gastroesophageal reflux disease, gastroesophageal reflux disease without esophagitis, and reflux esophagitis from meta-analysis study of genome-wide association studies involving 173,005 individuals (59,851 cases and 113,154 non-cases), 385,276 individuals (80,265 cases and 305,011 non-cases), 463,010 individuals (4360 cases and 458,650 non-cases), and 383,916 individuals (12,567 cases and 371,349 non-cases), respectively. Results: Genetic liability to major depressive disorder was positively associated with gastroesophageal reflux disease and its subtypes. Per one-unit increase in log-transformed odds ratio of major depressive disorder, the odds ratio was 1.31 (95% confidence interval [CI], 1.19-1.43; p = 1.64 x 10(-8)) for gastroesophageal reflux disease, 1.51 (95% CI, 1.15-1.98; p = 0.003) for gastroesophageal reflux disease without esophagitis, and 1.21 (95% CI, 1.05-1.40; p = 0.010) for reflux esophagitis. Reverse-direction analysis suggested that genetic liability to gastroesophageal reflux disease was causally related to increasing risk of major depressive disorder. Per one-unit increase in log-transformed odds ratio of gastroesophageal reflux disease, the odds ratio of major depressive disorder was 1.28 (95% confidence interval, 1.11-1.47; p = 1.0 x 10(-3)). Conclusions: This Mendelian randomization study suggests a bidirectional causal relationship between major depressive disorder and gastroesophageal reflux disease.

Ämnesord och genrebeteckningar

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Gastroenterologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Gastroenterology and Hepatology hsv//eng
gastroesophageal reflux disease
major depressive disorder
Mendelian randomization analysis

Biuppslag (personer, institutioner, konferenser, titlar ...)

Yuan, ShuaiKarolinska Institutet (författare)
Li, YeTianjin Med Univ, Dept Geriatr, Gen Hosp, Tianjin 300052, Peoples R China.;Tianjin Geriatr Inst, Tianjin 300052, Peoples R China. (författare)
Chen, JieZhejiang Univ, Ctr Global Hlth, Sch Med, Hangzhou 310030, Peoples R China.;Cent South Univ, Xiangya Hosp 3, Dept Gastroenterol, Changsha 410017, Peoples R China. (författare)
Li, XueZhejiang Univ, Sch Med, Sch Publ Hlth, Hangzhou 310030, Peoples R China.;Zhejiang Univ, Sch Med, Affiliated Hosp 2, Hangzhou 310030, Peoples R China.;Univ Edinburgh, Usher Inst, Ctr Global Hlth, Edinburgh EH8 9YL, Midlothian, Scotland. (författare)
Larsson, Susanna C.Karolinska Institutet,Uppsala universitet,Medicinsk epidemiologi,Inst Environm Med, Karolinska Inst, Unit Cardiovasc & Nutr Epidemiol, S-17177 Stockholm, Sweden.(Swepub:uu)susla720 (författare)
Zhang, QiangTianjin Med Univ, Dept Geriatr, Gen Hosp, Tianjin 300052, Peoples R China.;Tianjin Geriatr Inst, Tianjin 300052, Peoples R China. (författare)
Karolinska InstitutetTianjin Med Univ, Dept Geriatr, Gen Hosp, Tianjin 300052, Peoples R China.;Tianjin Geriatr Inst, Tianjin 300052, Peoples R China. (creator_code:org_t)

Sammanhörande titlar

Ingår i:Genes: MDPI13:112073-4425

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Av författaren/redakt...: Miao, Yuyang; Yuan, Shuai; Li, Ye; Chen, Jie; Li, Xue; Larsson, Susanna ...; visa fler...; Zhang, Qiang; visa färre...

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Gastroenterologi

Artiklar i publikationen: Genes

Av lärosätet: Uppsala universitet; Karolinska Institutet

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