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Research priorities...
Research priorities towards precision antibiotic therapy to improve patient care
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- Bulman, Zackery P. (author)
- Univ Illinois, Dept Pharm Practice, Chicago, IL 60612 USA.
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- Wicha, Sebastian G. (author)
- Univ Hamburg, Inst Pharm, Dept Clin Pharm, Hamburg, Germany.
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- Nielsen, Elisabet I., 1973- (author)
- Uppsala universitet,Institutionen för farmaci,Farmakometri
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- Lenhard, Justin R. (author)
- Calif Northstate Univ, Dept Clin & Adm Sci, Coll Pharm, Elk Grove, CA USA.
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- Nation, Roger L. (author)
- Monash Univ, Monash Inst Pharmaceut Sci, Drug Delivery Disposit & Dynam, Melbourne, Vic, Australia.
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- Theuretzbacher, Ursula (author)
- Ctr Antiinfect Agents, Vienna, Austria.
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- Derendorf, Hartmut (author)
- Univ Florida, Coll Pharm, Dept Pharmaceut, Gainesville, FL 32610 USA.
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- Tängdén, Thomas (author)
- Uppsala universitet,Infektionsmedicin
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- Zeitlinger, Markus (author)
- Med Univ Vienna, Dept Clin Pharmacol, Vienna, Austria.
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- Landersdorfer, Cornelia B. (author)
- Monash Univ, Ctr Med Use & Safety, Monash Inst Pharmaceut Sci, Melbourne, Vic, Australia.
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- Bulitta, Jürgen B. (author)
- Univ Florida, Coll Pharm, Dept Pharmacotherapy & Translat Res, Orlando, FL USA.
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- Friberg, Lena (author)
- Uppsala universitet,Institutionen för farmaci,Farmakokinetik och farmakodynamik
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- Li, Jian (author)
- Monash Univ, Monash Biomed Discovery Inst, Infect & Immun Program, Melbourne, Vic, Australia.;Monash Univ, Dept Microbiol, Melbourne, Vic, Australia.
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- Tsuji, Brian T. (author)
- Univ Buffalo, Dept Pharm Practice, Buffalo, NY USA.
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Univ Illinois, Dept Pharm Practice, Chicago, IL 60612 USA Univ Hamburg, Inst Pharm, Dept Clin Pharm, Hamburg, Germany. (creator_code:org_t)
- Elsevier, 2022
- 2022
- English.
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In: LANCET MICROBE. - : Elsevier. - 2666-5247. ; 3:10, s. e795-e802
- Related links:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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Abstract
Subject headings
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- Antibiotic resistance presents an incessant threat to our drug armamentarium that necessitates novel approaches to therapy. Over the past several decades, investigation of pharmacokinetic and pharmacodynamic (PKPD) principles has substantially improved our understanding of the relationships between the antibiotic, pathogen, and infected patient. However, crucial gaps in our understanding of the pharmacology of antibacterials and their optimal use in the care of patients continue to exist; simply attaining antibiotic exposures that are considered adequate based on traditional targets can still result in treatment being unsuccessful and resistance proliferation for some infections. It is this salient paradox that points to key future directions for research in antibiotic therapeutics. This Personal View discusses six priority areas for antibiotic pharmacology research: (1) antibiotic-pathogen interactions, (2) antibiotic targets for combination therapy, (3) mechanistic models that describe the time-course of treatment response, (4) understanding and modelling of host response to infection, (5) personalised medicine through therapeutic drug management, and (6) application of these principles to support development of novel therapies. Innovative approaches that enhance our understanding of antibiotic pharmacology and facilitate more accurate predictions of treatment success, coupled with traditional pharmacology research, can be applied at the population level and to individual patients to improve outcomes.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)
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- art (subject category)
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- By the author/editor
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Bulman, Zackery ...
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Wicha, Sebastian ...
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Nielsen, Elisabe ...
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Lenhard, Justin ...
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Nation, Roger L.
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Theuretzbacher, ...
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Derendorf, Hartm ...
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Tängdén, Thomas
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Zeitlinger, Mark ...
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Landersdorfer, C ...
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Bulitta, Jürgen ...
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Friberg, Lena
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Li, Jian
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Tsuji, Brian T.
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Infectious Medic ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Pharmacology and ...
- Articles in the publication
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LANCET MICROBE
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Uppsala University