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Considerations in t...
Considerations in the developability of peptides for oral administration when formulated together with transient permeation enhancers
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- Berg, Staffan (author)
- Uppsala universitet,Institutionen för farmaci,AstraZeneca, Pharmaceut Sci, R&D, Adv Drug Delivery, Gothenburg, Sweden.,Swedish Drug Delivery Center
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- Edlund, Helena (author)
- AstraZeneca, Clin Pharmacol & Safety Sci, R&D, Clin Pharmacol & Quantitat Pharmacol, Gothenburg, Sweden.
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- Goundry, William R. F. (author)
- AstraZeneca, Pharmaceut Sci, R&D, Early Chem Dev, Macclesfield, Cheshire, England.
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- Bergström, Christel, 1973- (author)
- Uppsala universitet,Institutionen för farmaci,Swedish Drug Delivery Center
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- Davies, Nigel M. (author)
- AstraZeneca, Pharmaceut Sci, R&D, Adv Drug Delivery, Gothenburg, Sweden.
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(creator_code:org_t)
- Elsevier, 2022
- 2022
- English.
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In: International Journal of Pharmaceutics. - : Elsevier. - 0378-5173 .- 1873-3476. ; 628
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- This paper reviews many of the properties of a peptide that need to be considered prior to development as an oral dosage form when co-formulated with a permeation enhancer to improve oral bioavailability, including the importance and implications of peptide half-life on variability in pharmacokinetic profiles. Clinical consider-ations in terms of food and drug-drug interactions are also discussed. The paper further gives a brief overview how permeation enhancers overcome barriers that limit oral absorption of peptides and thereby improve their oral bioavailability, albeit bioavailabilities are still low single digit and variability is high.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmaceutiska vetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmaceutical Sciences (hsv//eng)
Keyword
- Oral peptide delivery
- Peptide properties
- Permeation enhancer
- Bioavailability
- Variability
- Population pharmacokinetic modelling
Publication and Content Type
- ref (subject category)
- art (subject category)
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