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  • Vergaro, Giuseppe (author)

Cardiac biomarkers retain prognostic significance in patients with heart failure and chronic obstructive pulmonary disease

  • Article/chapterEnglish2021

Publisher, publication year, extent ...

  • 2021-11-26
  • Wolters Kluwer,2021
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-489752
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-489752URI
  • https://doi.org/10.2459/jcm.0000000000001281DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Aim: Chronic obstructive pulmonary disease (COPD) is a frequent comorbidity in patients with heart failure (HF). We assessed the influence of COPD on circulating levels and prognostic value of three HF biomarkers: N-terminal pro-B-type natriuretic peptide (NT-proBNP), high-sensitivity troponin T (hs-TnT), and soluble suppression of tumorigenesis-2 (sST2).Methods: Individual data from patients with chronic HF, known COPD status, NT-proBNP and hs-TnT values (n = 8088) were analysed. A subgroup (n = 3414) had also sST2 values.Results: Patients had a median age of 66 years (interquartile interval 57–74), 77% were men and 82% had HF with reduced ejection fraction. NT-proBNP, hs-TnT and sST2 were 1207 ng/l (487–2725), 17 ng/l (9–31) and 30 ng/ml (22–44), respectively. Patients with COPD (n = 1249, 15%) had higher NT-proBNP (P = 0.042) and hs-TnT (P < 0.001), but not sST2 (P = 0.165). Over a median 2.0-year follow-up (1.5–2.5), 1717 patients (21%) died, and 1298 (16%) died from cardiovascular causes; 2255 patients (28%) were hospitalized for HF over 1.8 years (0.9–2.1). NT-proBNP, hs-TnT and sST2 predicted the three end points regardless of COPD status. The best cut-offs from receiver-operating characteristics analysis were higher in patients with COPD than in those without. Patients with all three biomarkers higher than or equal to end-point- and COPD-status-specific cut-offs were also those with the worst prognosis.Conclusions: Among patients with HF, those with COPD have higher NT-proBNP and hs-TnT, but not sST2. All these biomarkers yield prognostic significance regardless of the COPD status.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Aimo, Alberto (author)
  • Januzzi, James L. (author)
  • Richards, A. Mark (author)
  • Lam, Carolyn S.P. (author)
  • Latini, Roberto (author)
  • Staszewsky, Lidia (author)
  • Anand, Inder S. (author)
  • Ueland, Thor (author)
  • Brunner-La Rocca, Hans-Peter (author)
  • Bayes-Genis, Antoni (author)
  • Lupón, Josep (author)
  • de Boer, Rudolf A. (author)
  • Yoshihisa, Akiomi (author)
  • Takeishi, Yasuchika (author)
  • Gustafsson, Ida (author)
  • Eggers, Kai M.,1962-Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Kardiologi(Swepub:uu)kaieg561 (author)
  • Huber, Kurt (author)
  • Gamble, Greg D. (author)
  • Leong, Kui Toh Gerard (author)
  • Yeo, Poh Shuan Daniel (author)
  • Ong, Hean Yee (author)
  • Jaufeerally, Fazlur (author)
  • Ng, Tze P. (author)
  • Troughton, Richard (author)
  • Doughty, Robert N. (author)
  • Emdin, Michele (author)
  • Passino, Claudio (author)
  • Uppsala universitetUppsala kliniska forskningscentrum (UCR) (creator_code:org_t)

Related titles

  • In:Journal of Cardiovascular Medicine: Wolters Kluwer23:1, s. 28-361558-20271558-2035

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