Inorganic nanoparticles for oral drug delivery: opportunities, barriers, and future perspectives

Inorganic nanoparticles for oral drug delivery : opportunities, barriers, and future perspectives

Asad, Shno (author): Uppsala universitet,Institutionen för farmaci,Science for Life Laboratory, SciLifeLab

Jacobsen, Ann-Christin (author): Uppsala universitet,Institutionen för farmaci

Teleki, Alexandra (author): Uppsala universitet,Institutionen för farmaci,Science for Life Laboratory, SciLifeLab

(creator_code:org_t)

Elsevier, 2022
2022
English.
In: Current Opinion in Chemical Engineering. - : Elsevier. - 2211-3398. ; 38

Related links:: https://doi.org/10.1...; show more...; https://uu.diva-port... (primary) (Raw object); https://urn.kb.se/re...; https://doi.org/10.1...; show less...

Abstract Subject headings

Oral delivery is the preferred route of drug administration due to patient compliance and convenience. Despite this, nanomedicines have so far primarily been developed for the parenteral route. Inorganic nanoparticles hold great promise as theranostics for oral drug delivery. This is gaining importance especially for the local treatment of gastrointestinal (GI) diseases. However, successful oral delivery of inorganic nanoparticles is challenged by complex physiological conditions in the GI tract. We discuss the main GI barriers and their impact on nanoparticle biotransformation and toxicity. An improved understanding of the complex interplay of inorganic nanoparticles with the dynamic GI environment can facilitate the development of efficient oral nanomedicines.

By the author/editor: Asad, Shno; Jacobsen, Ann-Ch ...; Teleki, Alexandr ...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Pharmaceutical S ...

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