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Design and rational...
Design and rationale of randomized evaluation of decreased usage of beta-blockers after acute myocardial infarction (REDUCE-AMI)
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- Yndigegn, Troels (author)
- Lund Univ, Sweden
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- Lindahl, Bertil, 1957- (author)
- Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Kardiologi,UCR,Uppsala Univ, Sweden
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- Alfredsson, Joakim, 1962- (author)
- Linköpings universitet,Medicinska fakulteten,Avdelningen för diagnostik och specialistmedicin,Region Östergötland, Kardiologiska kliniken US
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- Benatar, Jocelyne (author)
- Auckland City Hosp, New Zealand
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- Brandin, Lisa (author)
- Skaraborgs Sjukhus Skovde, Sweden
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- Erlinge, David (author)
- Lund Univ, Sweden
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- Haaga, Urban (author)
- Centralsjukhuset Karlstad, Sweden
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- Held, Claes, 1956- (author)
- Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Kardiologi,kardiologi,Uppsala Univ, Sweden
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- Johansson, Pelle (author)
- Heart & Lung Patients Assoc, Sweden
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- Karlström, Patric (author)
- Ryhov Hosp, Sweden
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- Kellerth, Thomas (author)
- Centralsjukhuset Karlstad, Sweden
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- Marandi, Toomas (author)
- Univ Tartu, Estonia; North Estonia Med Ctr, Estonia
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- Mars, Katarina (author)
- Karolinska Institutet,Karolinska Inst, Sweden
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- Ravn-Fischer, Annica, 1974 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
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- Sundström, Johan, Professor, 1971- (author)
- Uppsala universitet,Kardiologi,The George Institute for Global Health, University of New South Wales, 2052 Sydney, Australia,Uppsala Univ, Sweden; Univ New South Wales, Australia
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- Östlund, Ollie (author)
- Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Uppsala Univ, Sweden
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- Hofmann, Robin (author)
- Karolinska Institutet,Karolinska Inst, Sweden
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- Jernberg, Tomas (author)
- Karolinska Institutet,Karolinska Inst, Sweden
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(creator_code:org_t)
- 2022-12-13
- 2022
- English.
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In: European Heart Journal - Cardiovascular Pharmacotherapy. - : Oxford University Press. - 2055-6837 .- 2055-6845. ; 9:2, s. 192-197
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Abstract
Subject headings
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- BACKGROUND: Most trials showing benefit of beta-blocker treatment after myocardial infarction (MI) included patients with large MIs and are from an era before modern biomarker-based MI diagnosis and reperfusion treatment. The aim of the Randomized Evaluation of Decreased Usage of betabloCkErs after Acute Myocardial Infarction (REDUCE-AMI) trial is to determine whether long-term oral beta-blockade in patients with an acute MI and preserved left ventricular ejection fraction (EF) reduces the composite endpoint of death of any cause or recurrent MI.METHODS: It is a registry-based, randomized, parallel, open-label, multicenter trial performed at 38 centers in Sweden, one center in Estonia and six centers in New Zealand. About 5000 patients with an acute MI who have undergone coronary angiography and with EF ≥ 50% will be randomized to long-term treatment with beta-blockade or not. The primary endpoint is the composite endpoint of death of any cause or new non-fatal MI. There are several secondary endpoints, including all-cause death, cardiovascular death, new MI, readmission because of heart failure and atrial fibrillation, symptoms, functional status, health related quality of life after 6-10 weeks and after 1 year of treatment. Safety endpoints are bradycardia, AV-block II-III, hypotension, syncope or need for pacemaker, asthma or chronic obstructive pulmonary disease and stroke.CONCLUSION: The results from REDUCE-AMI will add important evidence regarding the effect of beta-blockers in patients with MI and preserved EF and may change guidelines and clinical practice.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- Beta-blocker
- Clinical trial
- Myocardial infarction
- Outcome
- RRCT
- Registry
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Yndigegn, Troels
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Lindahl, Bertil, ...
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Alfredsson, Joak ...
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Benatar, Jocelyn ...
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Brandin, Lisa
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Erlinge, David
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Haaga, Urban
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Held, Claes, 195 ...
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Johansson, Pelle
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Karlström, Patri ...
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Kellerth, Thomas
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Marandi, Toomas
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Mars, Katarina
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Ravn-Fischer, An ...
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Sundström, Johan ...
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Östlund, Ollie
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Hofmann, Robin
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Jernberg, Tomas
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
- Articles in the publication
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European Heart J ...
- By the university
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Uppsala University
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Karolinska Institutet
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Linköping University
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University of Gothenburg