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A single-cell trans...
A single-cell transcriptomic inventory of murine smooth muscle cells
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- Muhl, Lars (author)
- Karolinska Institutet
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- Mocci, Giuseppe (author)
- Karolinska Inst, Dept Med Huddinge, S-14157 Huddinge, Sweden.
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- Pietilä, Riikka (author)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi
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- Liu, Jianping (author)
- Karolinska Institutet
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- He, Liqun (author)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi
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- Genove, Guillem (author)
- Karolinska Inst, Dept Med Huddinge, S-14157 Huddinge, Sweden.
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- Leptidis, Stefanos (author)
- Karolinska Inst, Dept Med Huddinge, S-14157 Huddinge, Sweden.
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- Gustafsson, Sonja (author)
- Karolinska Inst, Dept Med Huddinge, S-14157 Huddinge, Sweden.
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- Buyandelger, Byambajav (author)
- Karolinska Inst, Dept Med Huddinge, S-14157 Huddinge, Sweden.
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- Raschperger, Elisabeth (author)
- Karolinska Inst, Dept Med Huddinge, S-14157 Huddinge, Sweden.
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- Hansson, Emil M. (author)
- Karolinska Inst, Dept Med Huddinge, S-14157 Huddinge, Sweden.
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- Bjorkegren, Johan L. M. (author)
- Karolinska Inst, Dept Med Huddinge, S-14157 Huddinge, Sweden.;Icahn Sch Med Mt Sinai, Icahn Inst Genom & Multiscale Biol, Dept Genet & Genet Sci, New York, NY 10029 USA.
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- Vanlandewijck, Michael, 1982- (author)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi,Karolinska Inst, Dept Med Huddinge, S-14157 Huddinge, Sweden
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- Lendahl, Urban (author)
- Karolinska Inst, Dept Cell & Mol Biol, S-17177 Stockholm, Sweden.
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- Betsholtz, Christer (author)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi,Karolinska Inst, Dept Med Huddinge, S-14157 Huddinge, Sweden
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Karolinska Institutet Karolinska Inst, Dept Med Huddinge, S-14157 Huddinge, Sweden (creator_code:org_t)
- Elsevier, 2022
- 2022
- English.
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In: Developmental Cell. - : Elsevier. - 1534-5807 .- 1878-1551. ; 57:20, s. 2426-
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https://uu.diva-port... (primary) (Raw object)
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Abstract
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- Smooth muscle cells (SMCs) execute important physiological functions in numerous vital organ systems, including the vascular, gastrointestinal, respiratory, and urogenital tracts. SMC differ morphologically and functionally at these different anatomical locations, but the molecular underpinnings of the differences remain poorly understood. Here, using deep single-cell RNA sequencing combined with in situ gene and pro-tein expression analysis in four murine organs-heart, aorta, lung, and colon-we identify a molecular basis for high-level differences among vascular, visceral, and airway SMC, as well as more subtle differences between, for example, SMC in elastic and muscular arteries and zonation of elastic artery SMC along the direction of blood flow. Arterial SMC exhibit extensive organotypic heterogeneity, whereas venous SMC are similar across organs. We further identify a specific SMC subtype within the pulmonary vasculature. This comparative SMC cross-organ resource offers insight into SMC subtypes and their specific functions.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Muhl, Lars
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Mocci, Giuseppe
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Pietilä, Riikka
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Liu, Jianping
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He, Liqun
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Genove, Guillem
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show more...
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Leptidis, Stefan ...
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Gustafsson, Sonj ...
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Buyandelger, Bya ...
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Raschperger, Eli ...
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Hansson, Emil M.
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Bjorkegren, Joha ...
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Vanlandewijck, M ...
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Lendahl, Urban
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Betsholtz, Chris ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Cell and Molecul ...
- Articles in the publication
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Developmental Ce ...
- By the university
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Uppsala University
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Karolinska Institutet