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  • Muhl, LarsKarolinska Institutet (author)

A single-cell transcriptomic inventory of murine smooth muscle cells

  • Article/chapterEnglish2022

Publisher, publication year, extent ...

  • Elsevier,2022
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-491686
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-491686URI
  • https://doi.org/10.1016/j.devcel.2022.09.015DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:151130529URI

Supplementary language notes

  • Language:English
  • Summary in:English

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Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Smooth muscle cells (SMCs) execute important physiological functions in numerous vital organ systems, including the vascular, gastrointestinal, respiratory, and urogenital tracts. SMC differ morphologically and functionally at these different anatomical locations, but the molecular underpinnings of the differences remain poorly understood. Here, using deep single-cell RNA sequencing combined with in situ gene and pro-tein expression analysis in four murine organs-heart, aorta, lung, and colon-we identify a molecular basis for high-level differences among vascular, visceral, and airway SMC, as well as more subtle differences between, for example, SMC in elastic and muscular arteries and zonation of elastic artery SMC along the direction of blood flow. Arterial SMC exhibit extensive organotypic heterogeneity, whereas venous SMC are similar across organs. We further identify a specific SMC subtype within the pulmonary vasculature. This comparative SMC cross-organ resource offers insight into SMC subtypes and their specific functions.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Mocci, GiuseppeKarolinska Inst, Dept Med Huddinge, S-14157 Huddinge, Sweden. (author)
  • Pietilä, RiikkaUppsala universitet,Institutionen för immunologi, genetik och patologi(Swepub:uu)riipi666 (author)
  • Liu, JianpingKarolinska Institutet (author)
  • He, LiqunUppsala universitet,Institutionen för immunologi, genetik och patologi(Swepub:uu)liqhe592 (author)
  • Genove, GuillemKarolinska Inst, Dept Med Huddinge, S-14157 Huddinge, Sweden. (author)
  • Leptidis, StefanosKarolinska Inst, Dept Med Huddinge, S-14157 Huddinge, Sweden. (author)
  • Gustafsson, SonjaKarolinska Inst, Dept Med Huddinge, S-14157 Huddinge, Sweden. (author)
  • Buyandelger, ByambajavKarolinska Inst, Dept Med Huddinge, S-14157 Huddinge, Sweden. (author)
  • Raschperger, ElisabethKarolinska Inst, Dept Med Huddinge, S-14157 Huddinge, Sweden. (author)
  • Hansson, Emil M.Karolinska Inst, Dept Med Huddinge, S-14157 Huddinge, Sweden. (author)
  • Bjorkegren, Johan L. M.Karolinska Inst, Dept Med Huddinge, S-14157 Huddinge, Sweden.;Icahn Sch Med Mt Sinai, Icahn Inst Genom & Multiscale Biol, Dept Genet & Genet Sci, New York, NY 10029 USA. (author)
  • Vanlandewijck, Michael,1982-Uppsala universitet,Institutionen för immunologi, genetik och patologi,Karolinska Inst, Dept Med Huddinge, S-14157 Huddinge, Sweden(Swepub:uu)micva660 (author)
  • Lendahl, UrbanKarolinska Inst, Dept Cell & Mol Biol, S-17177 Stockholm, Sweden. (author)
  • Betsholtz, ChristerUppsala universitet,Institutionen för immunologi, genetik och patologi,Karolinska Inst, Dept Med Huddinge, S-14157 Huddinge, Sweden(Swepub:uu)chbet517 (author)
  • Karolinska InstitutetKarolinska Inst, Dept Med Huddinge, S-14157 Huddinge, Sweden. (creator_code:org_t)

Related titles

  • In:Developmental Cell: Elsevier57:20, s. 2426-+1534-58071878-1551

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