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The 2022 Report on the Human Proteome from the HUPO Human Proteome Project

Omenn, Gilbert S. (author)
University of Michigan, Ann Arbor, Michigan 48109, United States;Institute for Systems Biology, Seattle, Washington 98109, United States
Lane, Lydie (author)
CALIPHO Group, SIB Swiss Institute of Bioinformatics and University of Geneva, 1015 Lausanne, Switzerland
Overall, Christopher M. (author)
University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada
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Pineau, Charles (author)
French Institute of Health and Medical Research, 35042 RENNES Cedex France
Packer, Nicolle H. (author)
Macquarie University, Sydney, New South Wales 2109, Australia,;Griffith University’s Institute for Glycomics, Sydney, New South Wales 2109, Australia
Cristea, Ileana M. (author)
Princeton University, Princeton, New Jersey 08544, United States
Lindskog, Cecilia (author)
Uppsala universitet,Science for Life Laboratory, SciLifeLab,Cancerprecisionsmedicin,Uppsala University, 752 36 Uppsala, Sweden
Weintraub, Susan T. (author)
University of Texas Health Science Center-San Antonio, San Antonio, Texas 78229-3900, United States
Orchard, Sandra (author)
EMBL-EBI, Hinxton, Cambridgeshire CB10 1SD, United Kingdom
Roehrl, Michael H. A. (author)
Memorial Sloan Kettering Cancer Center, New York, New York 10065, United States
Nice, Edouard (author)
Monash University, Clayton Victoria 3800, Australia
Liu, Siqi (author)
BGI Group, Shenzhen 518083, P. R. China
Bandeira, Nuno (author)
University of California, San Diego, La Jolla, California 92093, United States
Chen, Yu-Ju (author)
National Taiwan University, Academia Sinica, Nankang, Taipei 11529, Taiwan
Guo, Tiannan (author)
Westlake University Guomics Laboratory of Big Proteomic Data, Hangzhou 310024, Zhejiang Province P. R. China
Aebersold, Ruedi (author)
Institute of Molecular Systems Biology in ETH Zurich, 8092 Zurich, Switzerland
Moritz, Robert L. (author)
Institute for Systems Biology, Seattle, Washington 98109, United States
Deutsch, Eric W. (author)
Institute for Systems Biology, Seattle, Washington 98109, United States
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 (creator_code:org_t)
2022-11-01
2023
English.
In: Journal of Proteome Research. - : American Chemical Society (ACS). - 1535-3893 .- 1535-3907. ; 22:4, s. 1024-1042
Related links:
https://urn.kb.se/re...
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https://doi.org/10.1...
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  • Journal article (peer-reviewed)
Abstract Subject headings
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  • The 2022 Metrics of the Human Proteome from the HUPO Human Proteome Project (HPP) show that protein expression has now been credibly detected (neXtProt PE1 level) for 18 407 (93.2%) of the 19 750 predicted proteins coded in the human genome, a net gain of 50 since 2021 from data sets generated around the world and reanalyzed by the HPP. Conversely, the number of neXtProt PE2, PE3, and PE4 missing proteins has been reduced by 78 from 1421 to 1343. This represents continuing experimental progress on the human proteome parts list across all the chromosomes, as well as significant reclassifications. Meanwhile, applying proteomics in a vast array of biological and clinical studies continues to yield significant findings and growing integration with other omics platforms. We present highlights from the Chromosome-Centric HPP, Biology and Disease-driven HPP, and HPP Resource Pillars, compare features of mass spectrometry and Olink and Somalogic platforms, note the emergence of translation products from ribosome profiling of small open reading frames, and discuss the launch of the initial HPP Grand Challenge Project, “A Function for Each Protein”.

Subject headings

NATURVETENSKAP  -- Biologi -- Bioinformatik och systembiologi (hsv//swe)
NATURAL SCIENCES  -- Biological Sciences -- Bioinformatics and Systems Biology (hsv//eng)

Keyword

Biologi
Biology

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ref (subject category)
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