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Immunomodulatory effect of ethanol-soluble polypeptides from Atlantic cod (Gadus morhua)
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- Yuan, Zhen (author)
- Dalian Polytech Univ, Natl Engn Res Ctr Seafood, Sch Food Sci & Technol, Dalian 116034, Peoples R China.
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- Yang, Meilian (author)
- Dalian Polytech Univ, Natl Engn Res Ctr Seafood, Sch Food Sci & Technol, Dalian 116034, Peoples R China.
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- Zhu, Dongyang (author)
- Dalian Polytech Univ, Natl Engn Res Ctr Seafood, Sch Food Sci & Technol, Dalian 116034, Peoples R China.
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- Dalian Polytech Univ, Natl Engn Res Ctr Seafood, Sch Food Sci & Technol, Dalian 116034, Peoples R China Dalian Polytech Univ, Natl Engn Res Ctr Seafood, Sch Food Sci & Technol, Dalian 116034, Peoples R China.;China Agr Univ, Coll Food Sci & Nutr Engn, Beijing Adv Innovat Ctr Food Nutr & Human Hlth, Beijing 100083, Peoples R China. (creator_code:org_t)
- Elsevier, 2023
- 2023
- English.
- In: FOOD SCIENCE AND HUMAN WELLNESS. - : Elsevier. - 2213-4530. ; 12:4, s. 1192-1203
- Journal article (peer-reviewed)
Abstract
Subject headings
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- There are many active substances in Atlantic cod (Gadus morhua) explaining the variety of biological activities. In order to study the immunomodulatory activity and the mechanism of Atlantic cod peptides at the cellular level. In this study, cod peptides were isolated by 80% ethanol extraction method, the isolated ethanol-soluble cod peptides (CP-ES) were investigated and their immunomodulatory activity was verified. Additionally, CP-ES showed lower molecular weight and more hydrophobic amino acids. CP-ES could promote the proliferation of spleen lymphocytes and T lymphocytes in mice, suggesting that CP-ES may regulate adaptive immunity. It promoted the release of NO and the expression of iNOS, TNF-alpha, IL-6 and IL-1 beta genes in macrophages, suggesting that CP-ES may regulate innate immunity. CP-ES could promote the expression of TLR2 gene, and the peptides identified in CP-ES were docked with TLR2 to predict the peptides playing a major role in CP-ES. These results suggested that CP-ES may regulate the immune activity of both innate and adaptive lines.
Subject headings
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
Keyword
- Gadus morhua
- Immunomodulation
- Peptides
- TLR2
- Molecular docking
Publication and Content Type
- ref (subject category)
- art (subject category)
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- Yuan, Zhen
- Yang, Meilian
- Zhu, Dongyang
- Wu, Di
- Cheng, Shuzhen
- Wu, Chao
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- El-Seedi, Hesham
- Du, Ming
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- Uppsala University
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