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The Evolution of Ta...
The Evolution of Targeted Radionuclide Diagnosis of HER2-Positive Breast Cancer
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- Bragina, Olga D. (author)
- Russian Acad Sci, Canc Res Inst, Tomsk Natl Res Med Ctr, Tomsk 634009, Russia.;Natl Res Tomsk Polytech Univ, Tomsk 634050, Russia.
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- Deyev, Sergei M. (author)
- Natl Res Tomsk Polytech Univ, Tomsk 634050, Russia.;Russian Acad Sci, Shemyakin Ovchinnikov Inst Bioorgan Chem, Moscow 117997, Russia.
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- Chernov, Vladimir, I (author)
- Russian Acad Sci, Canc Res Inst, Tomsk Natl Res Med Ctr, Tomsk 634009, Russia.;Natl Res Tomsk Polytech Univ, Tomsk 634050, Russia.
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- Tolmachev, Vladimir (author)
- Uppsala universitet,Cancerprecisionsmedicin,Natl Res Tomsk Polytech Univ, Tomsk 634050, Russia.
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Russian Acad Sci, Canc Res Inst, Tomsk Natl Res Med Ctr, Tomsk 634009, Russia;Natl Res Tomsk Polytech Univ, Tomsk 634050, Russia. Natl Res Tomsk Polytech Univ, Tomsk 634050, Russia.;Russian Acad Sci, Shemyakin Ovchinnikov Inst Bioorgan Chem, Moscow 117997, Russia. (creator_code:org_t)
- 2022-07-21
- 2022
- English.
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In: ACTA NATURAE. - : RUSSIAN FEDERATION AGENCY SCIENCE & INNOVATION. - 2075-8251 .- 2075-8243. ; 14:2, s. 4-15
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Abstract
Subject headings
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- This review examines the evolution of the radionuclide diagnosis of HER2-positive breast cancer using various compounds as a targeting module in clinical practice: from full-length antibodies to a new group of small synthetic proteins called alternative scaffold proteins. This topic is of especial relevance today in view of the problems attendant to the detection of breast cancer with HER2/neu overexpression, which, in most cases, introduce errors in the treatment of patients. The results of clinical studies of radiopharmaceuticals based on affibody molecules, ADAPTs, and DARPins for SPECT and PET have demonstrated good tolerability of the compounds, their rapid excretion from the body, and the possibility to differentiate tumor sites depending on the HER2/neu status. This indicates that targeted radionuclide diagnosis holds promise and the need to continue research in this direction.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
Keyword
- breast cancer
- HER2/neu
- radionuclide diagnostics
- monoclonal antibody
- alternative scaffold proteins
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