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Cost-effectiveness ...
Cost-effectiveness of ticagrelor in patients with type 2 diabetes and coronary artery disease : a European economic evaluation of the THEMIS trial.
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Steg, Philippe Gabriel (author)
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Bhatt, Deepak L (author)
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- James, Stefan, 1964- (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Uppsala kliniska forskningscentrum (UCR),Kardiologi
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Darlington, Oliver (author)
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Hoskin, Louise (author)
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Simon, Tabassome (author)
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Fox, Kim M (author)
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Leiter, Lawrence A (author)
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Mehta, Shamir R (author)
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Harrington, Robert A (author)
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Himmelmann, Anders (author)
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Ridderstråle, Wilhelm (author)
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Andersson, Marielle (author)
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Bueno, Héctor (author)
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De Luca, Leonardo (author)
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Tank, Amarjeet (author)
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Mellström, Carl (author)
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McEwan, Phil (author)
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(creator_code:org_t)
- 2022-04-30
- 2022
- English.
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In: European Heart Journal - Cardiovascular Pharmacotherapy. - : Oxford University Press. - 2055-6837 .- 2055-6845. ; 8:8, s. 777-785
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https://uu.diva-port... (primary) (Raw object)
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Abstract
Subject headings
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- AIMS: To conduct a health economic evaluation of ticagrelor in patients with type 2 diabetes and coronary artery disease (CAD) from a multinational payer perspective. Cost-effectiveness and cost-utility of ticagrelor were evaluated in the overall effect of Ticagrelor on Health Outcomes in Diabetes Mellitus Patients Intervention Study (THEMIS) trial population and in the predefined patient group with prior percutaneous coronary intervention.METHODS AND RESULTS: A Markov model was developed to extrapolate patient outcomes over a lifetime horizon. The primary outcome was incremental cost-effectiveness ratios (ICERs), which were compared with conventional willingness-to-pay thresholds [€47 000/quality-adjusted life-year (QALY) in Sweden and €30 000/QALY in other countries].Treatment with ticagrelor resulted in QALY gains of up to 0.045 in the overall population and 0.099 in patients with percutaneous coronary intervention (PCI). Increased costs and benefits translated to ICERs ranged between €27 894 and €42 252/QALY across Sweden, Germany, Italy, and Spain in the overall population. In patients with prior PCI, estimated ICERs improved to €18 449, €20 632, €20 233, and €13 228/QALY in Sweden, Germany, Italy, and Spain, respectively, driven by higher event rates and treatment benefit.CONCLUSION: Based on THEMIS results, ticagrelor plus aspirin compared with aspirin alone may be cost-effective in some European countries in patients with T2DM and CAD and no prior myocardial infarction (MI) or stroke. Additionally, ticagrelor is likely to be cost-effective across European countries in patients with a history of PCI.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- Coronary artery disease
- Cost–effectiveness
- Percutaneous coronary intervention
- Ticagrelor
- Type 2 diabetes
Publication and Content Type
- ref (subject category)
- art (subject category)
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Steg, Philippe G ...
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Bhatt, Deepak L
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James, Stefan, 1 ...
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Darlington, Oliv ...
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Hoskin, Louise
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Simon, Tabassome
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Fox, Kim M
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Leiter, Lawrence ...
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Mehta, Shamir R
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Harrington, Robe ...
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Himmelmann, Ande ...
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Ridderstråle, Wi ...
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Andersson, Marie ...
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Bueno, Héctor
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De Luca, Leonard ...
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Tank, Amarjeet
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Mellström, Carl
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McEwan, Phil
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
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European Heart J ...
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Uppsala University