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Plasma apolipoprote...
Plasma apolipoprotein E levels in longitudinally followed patients with mild cognitive impairment and Alzheimer's disease
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- Giannisis, Andreas (author)
- Stockholms universitet,Institutionen för biokemi och biofysik,Stockholm Univ, Dept Biochem & Biophys, Svante Arrhenius Vag 16B, S-10691 Stockholm, Sweden.
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- Al-Grety, Asma (author)
- Uppsala universitet,Klinisk kemi
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- Carlsson, Henrik, 1987- (author)
- Uppsala universitet,Klinisk kemi
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- Patra, Kalicharan (author)
- Stockholms universitet,Institutionen för biokemi och biofysik,Stockholm Univ, Dept Biochem & Biophys, Svante Arrhenius Vag 16B, S-10691 Stockholm, Sweden.
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- Twohig, Daniel, 1976- (author)
- Stockholms universitet,Institutionen för biokemi och biofysik,Stockholm Univ, Dept Biochem & Biophys, Svante Arrhenius Vag 16B, S-10691 Stockholm, Sweden.
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- Sando, Sigrid Botne (author)
- Univ Hosp Trondheim, Dept Neurol, Trondheim, Norway.;Norwegian Univ Sci & Technol NTNU, Fac Med & Hlth Sci, Dept Neuromed & Movement Sci INB, Trondheim, Norway.
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- Lauridsen, Camilla (author)
- Norwegian Univ Sci & Technol NTNU, Fac Med & Hlth Sci, Dept Neuromed & Movement Sci INB, Trondheim, Norway.
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- Berge, Guro (author)
- Norwegian Univ Sci & Technol NTNU, Fac Med & Hlth Sci, Dept Neuromed & Movement Sci INB, Trondheim, Norway.
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- Grontvedt, Goril Rolfseng (author)
- Univ Hosp Trondheim, Dept Neurol, Trondheim, Norway.
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- Bråthen, Geir (author)
- Univ Hosp Trondheim, Dept Neurol, Trondheim, Norway.;Norwegian Univ Sci & Technol NTNU, Fac Med & Hlth Sci, Dept Neuromed & Movement Sci INB, Trondheim, Norway.
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- White, Linda R. (author)
- Univ Hosp Trondheim, Dept Neurol, Trondheim, Norway.;Norwegian Univ Sci & Technol NTNU, Fac Med & Hlth Sci, Dept Neuromed & Movement Sci INB, Trondheim, Norway.
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- Kultima, Kim (author)
- Uppsala universitet,Klinisk kemi
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- Nielsen, Henrietta M. (author)
- Stockholms universitet,Institutionen för biokemi och biofysik,Stockholm Univ, Dept Biochem & Biophys, Svante Arrhenius Vag 16B, S-10691 Stockholm, Sweden.
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(creator_code:org_t)
- 2022-08-24
- 2022
- English.
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In: Alzheimer's Research & Therapy. - : BioMed Central (BMC). - 1758-9193. ; 14:1
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Abstract
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- Background: Low levels of plasma apolipoprotein E (apoE) and presence of the APOE epsilon 4 allele are associated with an increased risk of Alzheimer's disease (AD). Although the increased risk of AD in APOE epsilon 4-carriers is well-established, the protein levels have received limited attention. Methods: We here report the total plasma apoE and apoE isoform levels at baseline from a longitudinally (24 months) followed cohort including controls (n = 3 9), patients with stable amnestic mild cognitive impairment during 24 months follow up (MCI-MCI, n = 3 0) , patients with amnestic MCI (aMCI) that during follow-up were clinically diagnosed with AD with dementia (ADD) (MCI-ADD, n = 28), and patients with AD with dementia (ADD) at baseline (ADD, n = 28). We furthermore assessed associations between plasma apoE levels with cerebrospinal fluid (CSF) AD biomarkers and alpha-synuclein, as well as both CSF and plasma neurofilament light chain (NfL), YKL-40 and kallikrein 6. Results: Irrespective of clinical diagnosis, the highest versus the lowest apoE levels were found in APOE epsilon 2/epsilon 3 versus APOE epsilon 4/epsilon 4 subjects, with the most prominent differences exhibited in females. Total plasma apoE levels were 32% and 21% higher in the controls versus MCI-ADD and ADD patients, respectively. Interestingly, MCI-ADD patients exhibited a 30% reduction in plasma apoE compared to MCI-MCI patients. This decrease appeared to be associated with brain amyloid-beta (A beta(42)) pathology regardless of disease status as assessed using the Amyloid, Tau, and Neurodegeneration (A/T/N) classification. In addition to the association between low plasma apoE and low levels of CSF A beta(42), lower apoE levels were also related to higher levels of CSF total tau (t-tau) and tau phosphorylated at Threonine 181 residue (p-tau) and NfL as well as a worse performance on the mini-mental-state-examination. In MCI-ADD patients, low levels of plasma apoE were associated with higher levels of CSF alpha-synuclein and kallikrein 6. No significant correlations between plasma apoE and the astrocytic inflammatory marker YKL40 were observed. Conclusions: Our results demonstrate important associations between low plasma apoE levels, A beta pathology, and progression from aMCI to a clinical ADD diagnosis.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
Keyword
- Apolipoprotein E
- Plasma
- Mass spectrometry
- Alzheimer's disease
- APOE epsilon 4
Publication and Content Type
- ref (subject category)
- art (subject category)
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Giannisis, Andre ...
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Al-Grety, Asma
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Carlsson, Henrik ...
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Patra, Kalichara ...
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Twohig, Daniel, ...
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Sando, Sigrid Bo ...
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Lauridsen, Camil ...
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Berge, Guro
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Grontvedt, Goril ...
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Bråthen, Geir
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White, Linda R.
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Kultima, Kim
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Nielsen, Henriet ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Psychiatry
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Alzheimer's Rese ...
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Uppsala University
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Stockholm University