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  • Bellavia, AndreaUniv Utrecht, Inst Risk Assessment Sci, Utrecht, Netherlands.;Harvard TH Chan Sch Publ Hlth, Dept Environm Hlth, Boston, MA USA. (author)

Association between chemical mixtures and female fertility in women undergoing assisted reproduction in Sweden and Estonia

  • Article/chapterEnglish2023

Publisher, publication year, extent ...

  • Elsevier,2023
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-495408
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-495408URI
  • https://doi.org/10.1016/j.envres.2022.114447DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:151531011URI
  • https://res.slu.se/id/publ/119215URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Objective: Women of reproductive age are exposed to ubiquitous chemicals such as phthalates, parabens, and per -and polyfluoroalkyl substances (PFAS), which have potential endocrine disrupting properties and might affect fertility. Our objective was to investigate associations between potential endocrine-disrupting chemicals (EDCs) and female fertility in two cohorts of women attending fertility clinics.Methods: In a total population of 333 women in Sweden and Estonia, we studied the associations between chemicals and female fertility, evaluating ovarian sensitivity index (OSI) as an indicator of ovarian response, as well as clinical pregnancy and live birth from fresh and frozen embryo transfers. We measured 59 chemicals in follicular fluid samples and detected 3 phthalate metabolites, di-2-ethylhexyl phthalate (DEHP) metabolites, 1 paraben, and 6 PFAS in > 90% of the women. Associations were evaluated using multivariable-adjusted linear or logistic regression, categorizing EDCs into quartiles of their distributions, as well as with Bayesian Kernel Ma-chine Regression.Results: We observed statistically significant lower OSI at higher concentrations of the sum of DEHP metabolites in the Swedish cohort (Q4 vs Q1, beta =-0.21, 95% CI:-0.38,-0.05) and methylparaben in the Estonian cohort (Q3 vs Q1, beta =-0.22, 95% CI:-0.44,-0.01). Signals of potential associations were also observed at higher concentrations of PFUnDA in both the combined population (Q2 vs. Q1,beta =-0.16, 95% CI-0.31,-0.02) and the Estonian population (Q2 vs. Q1,beta =-0.27, 95% CI-0.45,-0.08), and for PFOA in the Estonian population (Q4 vs. Q1, beta =-0.31, 95% CI-0.61,-0.01). Associations of chemicals with clinical pregnancy and live birth presented wide confidence intervals.Conclusions: Within a large chemical mixture, we observed significant inverse associations levels of DEHP me-tabolites and methylparaben, and possibly PFUnDA and PFOA, with OSI, suggesting that these chemicals may contribute to altered ovarian function and infertility in women.

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  • Zou, RunyuUniv Utrecht, Inst Risk Assessment Sci, Utrecht, Netherlands.;Univ Utrecht, Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands. (author)
  • Björvang, Richelle D.Karolinska Institutet (author)
  • Roos, KristineTallinn Univ Technol, Dept Chem & Biotechnol, Akad Tee 15, EE-12618 Tallinn, Estonia.;Nova Vita Clin AS, Tallinn, Estonia. (author)
  • Sjunnesson, YlvaSwedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för kliniska vetenskaper (KV),Department of Clinical Sciences(Swepub:slu)47737 (author)
  • Hallberg, IdaSwedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för kliniska vetenskaper (KV),Department of Clinical Sciences(Swepub:slu)48827 (author)
  • Holte, JanUppsala universitet,Reproduktionsbiologi,Carl von Linnekliniken, Uppsala, Sweden.(Swepub:uu)janho845 (author)
  • Pikki, AnneCarl von Linnekliniken, Uppsala, Sweden.;Uppsala Univ, Dept Womens & Childrens Hlth, Uppsala, Sweden. (author)
  • Lenters, VirissaUniv Utrecht, Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands. (author)
  • Portengen, LützenUniv Utrecht, Inst Risk Assessment Sci, Utrecht, Netherlands. (author)
  • Koekkoek, JaccoVrije Univ Amsterdam, Amsterdam Inst Life & Environm, Sect Environm & Hlth, Amsterdam, Netherlands. (author)
  • Lamoree, MarjaVrije Univ Amsterdam, Amsterdam Inst Life & Environm, Sect Environm & Hlth, Amsterdam, Netherlands. (author)
  • Van Duursen, MajorieVrije Univ Amsterdam, Amsterdam Inst Life & Environm, Sect Environm & Hlth, Amsterdam, Netherlands. (author)
  • Vermeulen, RoelUniv Utrecht, Inst Risk Assessment Sci, Utrecht, Netherlands.;Univ Utrecht, Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands. (author)
  • Salumets, AndresKarolinska Institutet (author)
  • Velthut-Meikas, AgneTallinn Univ Technol, Dept Chem & Biotechnol, Akad Tee 15, EE-12618 Tallinn, Estonia. (author)
  • Damdimopoulou, PauliinaKarolinska Institutet (author)
  • Univ Utrecht, Inst Risk Assessment Sci, Utrecht, Netherlands.;Harvard TH Chan Sch Publ Hlth, Dept Environm Hlth, Boston, MA USA.Univ Utrecht, Inst Risk Assessment Sci, Utrecht, Netherlands.;Univ Utrecht, Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands. (creator_code:org_t)
  • Sveriges lantbruksuniversitet

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  • In:Environmental Research: Elsevier216:Part 10013-93511096-0953

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