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Causal analysis of ...
Causal analysis of plasma IL-8 on carotid intima media thickness, a measure of subclinical atherosclerosis
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- Velasquez, Ilais Moreno (author)
- Gorgas Mem Inst Hlth Studies, Panama City, Panama.;Max Delbruck Ctr Mol Med Helmholtz Assoc, Mol Epidemiol Res Grp, Berlin, Germany.,Gorgas Memorial Institute for Health Studies (GMI)
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- Malarstig, Anders (author)
- Karolinska Institute
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- Baldassarre, Damiano (author)
- Univ Milan, Dept Med Biotechnol & Translat Med, Milan, Italy.;IRCCS, Ctr Cardiol Monzino, Milan, Italy.,Centro Cardiologico Monzino
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- Borne, Yan (author)
- Lund University,Lunds universitet,Nutritionsepidemiologi,Forskargrupper vid Lunds universitet,Nutrition Epidemiology,Lund University Research Groups
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- de Faire, Ulf (author)
- Karolinska Institute
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- Engström, Gunnar (author)
- Lund University,Lunds universitet,Kardiovaskulär forskning - epidemiologi,Forskargrupper vid Lunds universitet,Cardiovascular Research - Epidemiology,Lund University Research Groups
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- Eriksson, Per (author)
- Karolinska Institutet
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- Giral, Philippe (author)
- Sorbonne Univ, Grp Hop Pitie Salpetriere, AP HP, INSERM UMR1166,Cardiovasc Prevent Unit, Paris, France.,Paris-Sorbonne University
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- Humphries, Steve E. (author)
- UCL, Inst Cardiovasc Sci, Cardiovasc Genet, London, England.,University College London
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- Kurl, Sudhir (author)
- Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Kuopio Campus, Kuopio, Finland.,University of Eastern Finland
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- Leander, Karin (author)
- Karolinska Institutet,Karolinska Institute
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- Lind, Lars (author)
- Uppsala University,Uppsala universitet,Science for Life Laboratory, SciLifeLab,Centrum för klinisk forskning, Gävleborg,Uppsala kliniska forskningscentrum (UCR),Kardiologi,Geriatrik,Klinisk nutrition och metabolism,Molekylär epidemiologi,Radiologi,Klinisk epidemiologi,Uppsala Univ, Dept Med Sci, Clin Epidemiol, Uppsala, Sweden.
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- Linden, Anders (author)
- Karolinska Institutet
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- Orsini, Nicola (author)
- Karolinska Institutet
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- Pirro, Matteo (author)
- Univ Perugia, Dept Med, Internal Med Angiol & Arteriosclerosis Dis, Perugia, Italy.
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- Silveira, Angela (author)
- Karolinska Institutet
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- Smit, Andries J. (author)
- Univ Med Ctr Groningen, Dept Med, Groningen, Netherlands.;Isala Clin Zwolle, Dept Med, Zwolle, Netherlands.
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- Tremoli, Elena (author)
- Maria Cecilia Hosp, Cotignola, RA, Italy.
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- Veglia, Fabrizio (author)
- IRCCS, Ctr Cardiol Monzino, Milan, Italy.;Maria Cecilia Hosp, Cotignola, RA, Italy.
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- Strawbridge, Rona J. (author)
- Karolinska Institutet
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- Gigante, Bruna (author)
- Karolinska Institutet
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Gorgas Mem Inst Hlth Studies, Panama City, Panama;Max Delbruck Ctr Mol Med Helmholtz Assoc, Mol Epidemiol Res Grp, Berlin, Germany. Gorgas Memorial Institute for Health Studies (GMI) (creator_code:org_t)
- Elsevier, 2023
- 2023
- English.
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In: CURRENT RESEARCH IN TRANSLATIONAL MEDICINE. - : Elsevier. - 2452-3186. ; 71:1
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Abstract
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- Background: We investigated the causality of IL-8 on carotid intima-media thickness (c-IMT), a measure of sub-clinical atherosclerosis. Methods: The IMPROVE is a multicenter European study (n = 3,711). The association of plasma IL-8 with c-IMT (mm) was estimated by quantile regression. Genotyping was performed using the Illumina CardioMetabo and Immuno chips. Replication was attempted in three independent studies and a meta-analysis was performed using a random model. Results: In IMPROVE, each unit increase in plasma IL-8 was associated with an increase in median c-IMT measures (all p<0.03) in multivariable analyses. Linear regression identified rs117518778 and rs8057084 as associated with IL-8 levels and with measures of c-IMT. The two SNPs were combined in an IL-8-increasing genetic risk that showed causality of IL-8 on c-IMT in IMPROVE and in the UK Biobank (n = 22,179). The effect of IL-8 on c-IMT measures was confirmed in PIVUS (n = 1,016) and MDC-CC (n = 6,103). The association of rs8057084 with c-IMT was confirmed in PIVUS and UK Biobank with a pooled estimate effect (beta) of -0.006 with 95%CI (-0.008- -0.003). Conclusion: Our results indicate that genetic variants associated with plasma IL-8 also associate with c-IMT. However, we cannot infer causality of this association, as these variants lie outside of the IL8 locus. (c) 2022 The Author(s). Published by Elsevier Masson SAS. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
Keyword
- Chemokines
- Genetic association studies
- Subclinical atherosclerosis
- Carotid intima media thickness
- Cohort studies
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Velasquez, Ilais ...
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Malarstig, Ander ...
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Baldassarre, Dam ...
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Borne, Yan
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de Faire, Ulf
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Engström, Gunnar
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show more...
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Eriksson, Per
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Giral, Philippe
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Humphries, Steve ...
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Kurl, Sudhir
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Leander, Karin
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Lind, Lars
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Linden, Anders
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Orsini, Nicola
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Pirro, Matteo
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Silveira, Angela
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Smit, Andries J.
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Tremoli, Elena
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Veglia, Fabrizio
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Strawbridge, Ron ...
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Gigante, Bruna
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
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CURRENT RESEARCH ...
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Uppsala University
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Lund University
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Karolinska Institutet