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- Kaczor, Agnieszka A.Med Univ Lublin, Fac Pharm, Dept Synth & Chem Technol Pharmaceut Subst Comp M, 4A Chodzki St, PL-20093 Lublin, Poland.;Univ Eastern Finland, Sch Pharm, Yliopistonranta 1,POB 1627, FI-70211 Kuopio, Finland. (author)
Allosteric Modulators of Dopamine D-2 Receptors for Fine-Tuning of Dopaminergic Neurotransmission in CNS Diseases : Overview, Pharmacology, Structural Aspects and Synthesis
- Article/chapterEnglish2023
Publisher, publication year, extent ...
- 2022-12-25
- MDPI,2023
- electronicrdacarrier
Numbers
- LIBRIS-ID:oai:DiVA.org:uu-495638
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-495638URI
- https://doi.org/10.3390/molecules28010178DOI
Supplementary language notes
- Language:English
- Summary in:English
Part of subdatabase
- SwePubSwePub
Classification
Notes
- Allosteric modulation of G protein-coupled receptors (GPCRs) is nowadays a hot topic in medicinal chemistry. Allosteric modulators, i.e., compounds which bind in a receptor site topologically distinct from orthosteric sites, exhibit a number of advantages. They are more selective, safer and display a ceiling effect which prevents overdosing. Allosteric modulators of dopamine D-2 receptor are potential drugs against a number of psychiatric and neurological diseases, such as schizophrenia and Parkinson's disease. In this review, an insightful summary of current research on D-2 receptor modulators is presented, ranging from their pharmacology and structural aspects of ligand-receptor interactions to their synthesis.
Subject headings and genre
- NATURVETENSKAP Biologi Biokemi och molekylärbiologi hsv//swe
- NATURAL SCIENCES Biological Sciences Biochemistry and Molecular Biology hsv//eng
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Farmakologi och toxikologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine Pharmacology and Toxicology hsv//eng
- allosteric modulation
- dopamine D-2 receptor
- G protein-couple receptors
- molecular modeling
- drug synthesis
Added entries (persons, corporate bodies, meetings, titles ...)
- Wrobel, Tomasz M.Med Univ Lublin, Fac Pharm, Dept Synth & Chem Technol Pharmaceut Subst Comp M, 4A Chodzki St, PL-20093 Lublin, Poland. (author)
- Bartuzi, DamianUppsala universitet,Beräkningsbiologi och bioinformatik,Science for Life Laboratory, SciLifeLab,Med Univ Lublin, Fac Pharm, Dept Synth & Chem Technol Pharmaceut Subst Comp M, 4A Chodzki St, PL-20093 Lublin, Poland.(Swepub:uu)damba256 (author)
- Med Univ Lublin, Fac Pharm, Dept Synth & Chem Technol Pharmaceut Subst Comp M, 4A Chodzki St, PL-20093 Lublin, Poland.;Univ Eastern Finland, Sch Pharm, Yliopistonranta 1,POB 1627, FI-70211 Kuopio, Finland.Med Univ Lublin, Fac Pharm, Dept Synth & Chem Technol Pharmaceut Subst Comp M, 4A Chodzki St, PL-20093 Lublin, Poland. (creator_code:org_t)
Related titles
- In:Molecules: MDPI28:11431-51571420-3049
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