Nomograms including the UBC (R) Rapid test to detect primary bladder cancer based on a multicentre dataset

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Nomograms including the UBC (R) Rapid test to detect primary bladder cancer based on a multicentre dataset

Meisl, Christina J. (author): Charite Univ Med Berlin, Dept Urol, Charitepl 1, D-10117 Berlin, Germany.;Free Univ Berlin, Berlin, Germany.;Humbold Univ Berlin, Berlin, Germany.;Berlin Inst Hlth, Berlin, Germany.

Karakiewicz, Pierre, I (author): Univ Montreal, Dept Surg, Montreal, PQ, Canada.

Einarsson, Roland (author): IDL Biotech, Bromma, Sweden.

Koch, Stefan (author): HELIOS Hosp Bad Saarow, Dept Pathol, Bad Saarow Pieskow, Germany.;Brandenburg Med Sch Theodor Fontane, Neuruppin, Germany.

Hallmann, Steffen (author): HELIOS Hosp Bad Saarow, Dept Urol, Bad Saarow Pieskow, Germany.

Weiss, Sarah (author): HELIOS Hosp Bad Saarow, Dept Urol, Bad Saarow Pieskow, Germany.

Hemdan, Tammer, 1974- (author): Uppsala universitet,Urologkirurgi,Uppsala Univ, Dept Surg Sci, Uppsala, Sweden.

Malmström, Per-Uno (author): Uppsala universitet,Urologkirurgi,Uppsala Univ, Dept Surg Sci, Uppsala, Sweden.

Styrke, Johan (author): Umeå universitet,Urologi och andrologi,Umea Univ, Dept Surg & Perioperat Sci Urol & Androl, Umea, Sweden.

Sherif, Amir (author): Umeå universitet,Urologi och andrologi,Umea Univ, Dept Surg & Perioperat Sci Urol & Androl, Umea, Sweden.

Hasan, Mudhar N. (author): Danderyd Hosp, Dept Urol, Danderyd, Sweden.

Pichler, Renate (author): Med Univ Innsbruck, Dept Urol, Innsbruck, Austria.

Tulchiner, Gennadi (author): Med Univ Innsbruck, Dept Urol, Innsbruck, Austria.

Palou, Joan (author): Autonomous Univ Barcelona, Dept Urol, Fundacio Puigvert, Barcelona, Spain.,Univ Hosp Schleswig Holstein, Dept Urol, Campus Lubeck, Lubeck, Germany.

Faba, Oscar Rodriguez (author): Autonomous Univ Barcelona, Dept Urol, Fundacio Puigvert, Barcelona, Spain.

Hennenlotter, Joerg (author): Univ Hosp Tubingen, Dept Urol, Tubingen, Germany.

Stenzl, Arnulf (author): Univ Hosp Tubingen, Dept Urol, Tubingen, Germany.

Ritter, Rene (author): Diakonie Klinikum Stuttgart, Dept Urol, Stuttgart, Germany.,Natl Univ Singapore Hosp, Dept Urol, Singapore, Singapore.

Niegisch, Guenter (author): Heinrich Heine Univ Dusseldorf, Dept Urol, Fac Med, Dusseldorf, Germany.

Grunewald, Camilla M. (author): Heinrich Heine Univ Dusseldorf, Dept Urol, Fac Med, Dusseldorf, Germany.

Schlomm, Thorsten (author): Charite Univ Med Berlin, Dept Urol, Charitepl 1, D-10117 Berlin, Germany.;Free Univ Berlin, Berlin, Germany.;Humbold Univ Berlin, Berlin, Germany.;Berlin Inst Hlth, Berlin, Germany.

Friedersdorff, Frank (author): Charite Univ Med Berlin, Dept Urol, Charitepl 1, D-10117 Berlin, Germany.;Free Univ Berlin, Berlin, Germany.;Humbold Univ Berlin, Berlin, Germany.;Berlin Inst Hlth, Berlin, Germany.;Evangel Krankenhaus Konigin Elisabeth Herzberge, Dept Urol, Berlin, Germany.

Barski, Dimitri (author): Rheinland Klinikum Neuss, Dept Urol, Neuss, Germany.

Otto, Thomas (author): Rheinland Klinikum Neuss, Dept Urol, Neuss, Germany.;Univ Duisburg Essen, Med Fac, Essen, Germany.

Goessl, Andreas (author): HELIOS Hosp Krefeld, Dept Urol, Krefeld, Germany.

Arndt, Christian (author): HELIOS Hosp Krefeld, Dept Urol, Krefeld, Germany.

Esuvaranathan, Kesavan (author): Natl Univ Singapore Hosp, Dept Urol, Singapore, Singapore.

Kesavan, Nisha R. (author): Natl Univ Singapore Hosp, Dept Urol, Singapore, Singapore.

Zhijiang, Zang (author)

Kramer, Mario W. (author): Univ Hosp Schleswig Holstein, Dept Urol, Campus Lubeck, Lubeck, Germany.

Hennig, Martin J. P. (author): Univ Hosp Schleswig Holstein, Dept Urol, Campus Lubeck, Lubeck, Germany.

Ecke, Thorsten H. (author): Charite Univ Med Berlin, Dept Urol, Charitepl 1, D-10117 Berlin, Germany.;Free Univ Berlin, Berlin, Germany.;Humbold Univ Berlin, Berlin, Germany.;Berlin Inst Hlth, Berlin, Germany.;HELIOS Hosp Bad Saarow, Dept Urol, Bad Saarow Pieskow, Germany.

Weiß, Sarah (author)

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Charite Univ Med Berlin, Dept Urol, Charitepl 1, D-10117 Berlin, Germany;Free Univ Berlin, Berlin, Germany.;Humbold Univ Berlin, Berlin, Germany.;Berlin Inst Hlth, Berlin, Germany. Univ Montreal, Dept Surg, Montreal, PQ, Canada. (creator_code:org_t)

2022-01-11
2022
English.
In: BJU International. - : John Wiley & Sons. - 1464-4096 .- 1464-410X. ; 130:6, s. 754-763

Related links:: https://doi.org/10.1...; show more...; https://onlinelibrar...; https://umu.diva-por... (primary) (Raw object); https://urn.kb.se/re...; https://doi.org/10.1...; https://urn.kb.se/re...; show less...

Journal article (peer-reviewed)

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Objectives To evaluate the clinical utility of the urinary bladder cancer antigen test UBC (R) Rapid for the diagnosis of bladder cancer (BC) and to develop and validate nomograms to identify patients at high risk of primary BC. Patients and Methods Data from 1787 patients from 13 participating centres, who were tested between 2012 and 2020, including 763 patients with BC, were analysed. Urine samples were analysed with the UBC (R) Rapid test. The nomograms were developed using data from 320 patients and externally validated using data from 274 patients. The diagnostic accuracy of the UBC (R) Rapid test was evaluated using receiver-operating characteristic curve analysis. Brier scores and calibration curves were chosen for the validation. Biopsy-proven BC was predicted using multivariate logistic regression. Results The sensitivity, specificity, and area under the curve for the UBC (R) Rapid test were 46.4%, 75.5% and 0.61 (95% confidence interval [CI] 0.58-0.64) for low-grade (LG) BC, and 70.5%, 75.5% and 0.73 (95% CI 0.70-0.76) for high-grade (HG) BC, respectively. Age, UBC (R) Rapid test results, smoking status and haematuria were identified as independent predictors of primary BC. After external validation, nomograms based on these predictors resulted in areas under the curve of 0.79 (95% CI 0.72-0.87) and 0.95 (95% CI: 0.92-0.98) for predicting LG-BC and HG-BC, respectively, showing excellent calibration associated with a higher net benefit than the UBC (R) Rapid test alone for low and medium risk levels in decision curve analysis. The R Shiny app allows the results to be explored interactively and can be accessed at www.blucab-index. net. Conclusion The UBC (R) Rapid test alone has limited clinical utility for predicting the presence of BC. However, its combined use with BC risk factors including age, smoking status and haematuria provides a fast, highly accurate and non-invasive tool for screening patients for primary LG-BC and especially primary HG-BC.

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Urology and Neph ...

Articles in the publication: BJU Internationa ...

By the university: Uppsala University; Umeå University

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Nomograms including the UBC (R) Rapid test to detect primary bladder cancer based on a multicentre dataset

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