Search: onr:"swepub:oai:DiVA.org:uu-495880" >
Dimerization of the...
Dimerization of the C-type lectin-like receptor CD93 promotes its binding to Multimerin-2 in endothelial cells
-
- Barbera, Stefano (author)
- Uppsala universitet,Vaskulärbiologi,Science for Life Laboratory, SciLifeLab,Univ Siena, Dept Biotechnol Chem & Pharm, I-53100 Siena, Italy.
-
- Raucci, Luisa (author)
- Univ Siena, Dept Biotechnol Chem & Pharm, I-53100 Siena, Italy.
-
- Tassone, Giusy (author)
- Univ Siena, Dept Biotechnol Chem & Pharm, I-53100 Siena, Italy.
-
show more...
-
- Tinti, Laura (author)
- Toscana Life Sci Fdn, I-53100 Siena, Italy.
-
- Prischi, Filippo (author)
- Univ Essex, Sch Life Sci, Colchester CO4 3SQ, England.
-
- Santucci, Annalisa (author)
- Univ Siena, Dept Biotechnol Chem & Pharm, I-53100 Siena, Italy.
-
- Mongiat, Maurizio (author)
- IRCCS, Dept Res & Diag, Div Mol Oncol, Ctr Riferimento Oncol Aviano CRO, I-33081 Aviano, Italy.
-
- Tosi, Gian Marco (author)
- Univ Siena, Dept Med Surg & Neurosci, Ophthalmol Unit, I-53100 Siena, Italy.
-
- Galvagni, Federico (author)
- Univ Siena, Dept Biotechnol Chem & Pharm, I-53100 Siena, Italy.
-
- Dimberg, Anna (author)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Vaskulärbiologi
-
- Pozzi, Cecilia (author)
- Univ Siena, Dept Biotechnol Chem & Pharm, I-53100 Siena, Italy.
-
- Orlandini, Maurizio (author)
- Univ Siena, Dept Biotechnol Chem & Pharm, I-53100 Siena, Italy.;Univ Siena, Dept Biotechnol Chem & Pharm, Via A Moro 2, I-53100 Siena, Italy.
-
show less...
-
(creator_code:org_t)
- Elsevier, 2023
- 2023
- English.
-
In: International Journal of Biological Macromolecules. - : Elsevier. - 0141-8130 .- 1879-0003. ; 224, s. 453-464
- Related links:
-
https://doi.org/10.1...
-
show more...
-
https://uu.diva-port... (primary) (Raw object)
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- Blocking the signaling activated by the plasma membrane receptor CD93 has recently been demonstrated a useful tool in antiangiogenic treatment and oncotherapy. In the proliferating endothelium, CD93 regulates cell adhesion, migration, and vascular maturation, yet it is unclear how CD93 interacts with the extracellular matrix activating signaling pathways involved in the vascular remodeling. Here for the first time we show that in endothelial cells CD93 is structured as a dimer and that this oligomeric form is physiologically instrumental for the binding of CD93 to its ligand Multimerin-2. Crystallographic X-ray analysis of recombinant CD93 reveals the crucial role played by the C-type lectin-like and sushi-like domains in arranging as an antiparallel dimer to achieve a functional binding state, providing key information for the future design of new drugs able to hamper CD93 function in neovascular pathologies.
Subject headings
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
Keyword
- Angiogenesis
- CD93
- Crystallography
- Mass spectrometry
- Neovascularization
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Barbera, Stefano
-
Raucci, Luisa
-
Tassone, Giusy
-
Tinti, Laura
-
Prischi, Filippo
-
Santucci, Annali ...
-
show more...
-
Mongiat, Maurizi ...
-
Tosi, Gian Marco
-
Galvagni, Federi ...
-
Dimberg, Anna
-
Pozzi, Cecilia
-
Orlandini, Mauri ...
-
show less...
- About the subject
-
- NATURAL SCIENCES
-
NATURAL SCIENCES
-
and Biological Scien ...
-
and Biochemistry and ...
- Articles in the publication
-
International Jo ...
- By the university
-
Uppsala University