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Early response eval...
Early response evaluation by single cell signaling profiling in acute myeloid leukemia
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- Tislevoll, Benedicte Sjo (author)
- Univ Bergen, Ctr Canc Biomarkers CCBIO, Dept Clin Sci, Bergen, Norway.
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- Hellesoy, Monica (author)
- Haukeland Hosp, Dept Internal Med, Hematol Sect, Bergen, Norway.
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- Fagerholt, Oda Helen Eck (author)
- Univ Bergen, Ctr Canc Biomarkers CCBIO, Dept Clin Sci, Bergen, Norway.
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- Gullaksen, Stein-Erik (author)
- Haukeland Hosp, Dept Internal Med, Hematol Sect, Bergen, Norway.
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- Srivastava, Aashish (author)
- K2 Haukeland Univ Hosp, Clin Lab, Genome Core Facil, Bergen, Norway.
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- Birkeland, Even (author)
- Univ Bergen, Prote Facil Univ Bergen Probe, Bergen, Norway.
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- Kleftogiannis, Dimitrios (author)
- Univ Bergen, Ctr Canc Biomarkers CCBIO, Dept Clin Sci, Bergen, Norway.;Univ Bergen, Ctr Canc, Dept Informat, Biomarkers & Computat Biol Unit, Bergen, Norway.
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- Ayuda-Duran, Pilar (author)
- Norwegian Radium Hosp, Inst Canc Res, Dept Mol Cell Biol, Montebello, N-0379 Oslo, Norway.;Univ Oslo, Fac Med, Ctr Canc Cell Reprogramming, Inst Clin Med, N-0318 Oslo, Norway.
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- Piechaczyk, Laure (author)
- Norwegian Radium Hosp, Inst Canc Res, Dept Mol Cell Biol, Montebello, N-0379 Oslo, Norway.;Univ Oslo, Fac Med, Ctr Canc Cell Reprogramming, Inst Clin Med, N-0318 Oslo, Norway.;Univ Oslo, Facu Med, Oslo, Norway.
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- Tadele, Dagim Shiferaw (author)
- Oslo Univ Hosp, Dept Mol Genet, Div Lab Med, Oslo, Norway.;Cleveland Clin, Dept Translat Hematol & Oncol Res, Cleveland, OH 44106 USA.
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- Skavland, Jorn (author)
- Univ Bergen, Ctr Canc Biomarkers CCBIO, Dept Clin Sci, Bergen, Norway.
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- Baliakas, Panagiotis, 1977- (author)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Cancerprecisionsmedicin
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- Hovland, Randi (author)
- Haukeland Hosp, Ctr Med Genet & Mol Med, Bergen, Norway.
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- Andresen, Vibeke (author)
- Univ Bergen, Ctr Canc Biomarkers CCBIO, Dept Clin Sci, Bergen, Norway.
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- Seternes, Ole Morten (author)
- UiT Arctic Univ Norway, Dept Pharm, N-9037 Tromso, Norway.
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- Tvedt, Tor Henrik Anderson (author)
- Oslo Univ Hosp, Dept Hematol, Oslo, Norway.
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- Aghaeepour, Nima (author)
- Stanford Univ, Dept Anesthesiol Perioperat & Pain Med, Sch Med, Stanford, CA 94121 USA.;Stanford Univ, Dept Pediat, Sch Med, Stanford, CA 94121 USA.;Stanford Univ, Dept Biomed Informat, Sch Med, Stanford, CA 94121 USA.
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- Gavasso, Sonia (author)
- Univ Bergen, Ctr Canc Biomarkers CCBIO, Dept Clin Sci, Bergen, Norway.;Univ Bergen, Ctr Clin Treatment Res NeuroSysMed, Dept Clin Sci, Bergen, Norway.
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- Porkka, Kimmo (author)
- Helsinki Univ Hosp, Dept Hematol, Comprehens Canc Ctr, Helsinki, Finland.
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- Jonassen, Inge (author)
- Univ Bergen, Ctr Canc, Dept Informat, Biomarkers & Computat Biol Unit, Bergen, Norway.
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- Floisand, Yngvar (author)
- Univ Oslo, Fac Med, Ctr Canc Cell Reprogramming, Inst Clin Med, N-0318 Oslo, Norway.;Oslo Univ Hosp, Dept Hematol, Oslo, Norway.
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- Enserink, Jorrit (author)
- Norwegian Radium Hosp, Inst Canc Res, Dept Mol Cell Biol, Montebello, N-0379 Oslo, Norway.;Univ Oslo, Fac Med, Ctr Canc Cell Reprogramming, Inst Clin Med, N-0318 Oslo, Norway.;Univ Oslo, Fac Math & Nat Sci, Sect Biochem & Mol Biol, N-0037 Oslo, Norway.
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- Blaser, Nello (author)
- Univ Bergen, Dept Informat, Bergen, Norway.
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- Gjertsen, Bjorn Tore (author)
- Univ Bergen, Ctr Canc Biomarkers CCBIO, Dept Clin Sci, Bergen, Norway.;Haukeland Hosp, Dept Internal Med, Hematol Sect, Bergen, Norway.
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Univ Bergen, Ctr Canc Biomarkers CCBIO, Dept Clin Sci, Bergen, Norway Haukeland Hosp, Dept Internal Med, Hematol Sect, Bergen, Norway. (creator_code:org_t)
- 2023-01-07
- 2023
- English.
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In: Nature Communications. - : Springer Nature. - 2041-1723. ; 14:1
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Abstract
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- Aberrant pro-survival signaling is a hallmark of cancer cells, but the response to chemotherapy is poorly understood. In this study, we investigate the initial signaling response to standard induction chemotherapy in a cohort of 32 acute myeloid leukemia (AML) patients, using 36-dimensional mass cytometry. Through supervised and unsupervised machine learning approaches, we find that reduction of extracellular-signal-regulated kinase (ERK) 1/2 and p38 mitogen-activated protein kinase (MAPK) phosphorylation in the myeloid cell compartment 24 h post-chemotherapy is a significant predictor of patient 5-year overall survival in this cohort. Validation by RNA sequencing shows induction of MAPK target gene expression in patients with high phosphoERK1/2 24 h post-chemotherapy, while proteomics confirm an increase of the p38 prime target MAPK activated protein kinase 2 (MAPKAPK2). In this study, we demonstrate that mass cytometry can be a valuable tool for early response evaluation in AML and elucidate the potential of functional signaling analyses in precision oncology diagnostics.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
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- art (subject category)
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- By the author/editor
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Tislevoll, Bened ...
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Hellesoy, Monica
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Fagerholt, Oda H ...
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Gullaksen, Stein ...
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Srivastava, Aash ...
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Birkeland, Even
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Kleftogiannis, D ...
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Ayuda-Duran, Pil ...
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Piechaczyk, Laur ...
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Tadele, Dagim Sh ...
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Skavland, Jorn
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Baliakas, Panagi ...
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Hovland, Randi
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Andresen, Vibeke
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Seternes, Ole Mo ...
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Tvedt, Tor Henri ...
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Aghaeepour, Nima
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Gavasso, Sonia
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Porkka, Kimmo
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Jonassen, Inge
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Floisand, Yngvar
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Enserink, Jorrit
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Blaser, Nello
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Gjertsen, Bjorn ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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Nature Communica ...
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Uppsala University