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Enhancement of anti...
Enhancement of antiviral drug efficacy through multimodal mechanism of Au nanoparticles decorated ZnO tetrapods
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Suryawanshi, Rahul K. (author)
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Patil, Chandrashekhar D. (author)
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Koujah, Lulia (author)
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- Panda, Pritam Kumar, PhD Student, 1991- (author)
- Uppsala universitet,Materialteori
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Singh, Sudhanshu Kumar (author)
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Agelidis, Alex (author)
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Volety, Ipsita (author)
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Siebert, Leonard (author)
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Adelung, Rainer (author)
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- Ahuja, Rajeev, 1965- (author)
- Uppsala universitet,Materialteori,Applied Materials Physics, Department of Materials Science and Engineering, Royal Institute of Technology (KTH)
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Mishra, Yogendra Kumar (author)
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Shukla, Deepak (author)
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(creator_code:org_t)
- English.
- Related links:
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https://urn.kb.se/re...
Abstract
Subject headings
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- Nanoparticles have been well studied for controlling viral infections. However, very little knowledge exists on their potential use as an adjuvant for enhancing antiviral drug efficacy and reducing toxicity. Herein, we describe gold nanoparticle decorated zinc oxide tetrapods (ANZOT) that electrostatically neutralize viral infections. Given their negative charge distribution caused by engineered oxygen vacancies, ANZOT can prevent herpes simplex virus-1 and the novel human coronavirus, SARS-CoV-2 from infecting cells. More notably, when ANZOT was used as an adjuvant, several fold lower than normally used concentrations of a nucleoside analog, acyclovir or a preclinical antiviral compound, BX795, were enough to inhibit infection and eliminate drug toxicity. BX795 was found to exert its antiviral benefits through inhibition of cellular protein kinase C (α and ζ). Cumulatively our findings highlight an innovative use of ANZOT as a drug adjuvant for superior broad-spectrum effects against viral infections.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmaceutiska vetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmaceutical Sciences (hsv//eng)
Keyword
- Herpesvirus
- BX795
- Zinc Oxide Tetrapod
- gold nanoparticles
- antiviral
- virus neutralization
- Farmaceutisk vetenskap
- Pharmaceutical Science
Publication and Content Type
- vet (subject category)
- ovr (subject category)
To the university's database
- By the author/editor
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Suryawanshi, Rah ...
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Patil, Chandrash ...
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Koujah, Lulia
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Panda, Pritam Ku ...
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Singh, Sudhanshu ...
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Agelidis, Alex
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show more...
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Volety, Ipsita
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Siebert, Leonard
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Adelung, Rainer
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Ahuja, Rajeev, 1 ...
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Mishra, Yogendra ...
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Shukla, Deepak
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Pharmaceutical S ...
- By the university
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Uppsala University