Search: onr:"swepub:oai:DiVA.org:uu-497029" > Validating the risk...
Fältnamn | Indikatorer | Metadata |
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000 | 04250naa a2200505 4500 | |
001 | oai:DiVA.org:uu-497029 | |
003 | SwePub | |
008 | 230223s2024 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4970292 URI |
024 | 7 | a https://doi.org/10.1093/bjs/znad3662 DOI |
040 | a (SwePub)uu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Annebäck, Matildau Uppsala universitet,Endokrinkirurgi4 aut0 (Swepub:uu)matan693 |
245 | 1 0 | a Validating the risk of hypoparathyroidism after total thyroidectomy in a population-based cohort :b plea for improved follow-up |
264 | 1 | b Oxford University Press,c 2024 |
338 | a electronic2 rdacarrier | |
500 | a Title in the list of papers of Matilda Annebäck's thesis: Validating the risk of hypoparathyroidism after total thyroidectomy in a population-based cohort: a plea for improved follow-up | |
520 | a BackgroundA previous nationwide study from Sweden showed that the rate of permanent hypoparathyroidism is high and under-rated in the Swedish Quality Register. This retrospective population-based study aimed to validate the rate and diagnosis of permanent hypoparathyroidism found in the previous study. A secondary aim was to assess the relationship between the rate of low parathyroid hormone (PTH) levels within 24 h after surgery and the rate of permanent hypoparathyroidism.MethodsAll patients who underwent total thyroidectomy from 2005 to 2015 in a region of Sweden were included. Data were retrieved from local health records, the National Patient Registry, the Swedish Prescribed Drug Registry, and the Swedish Quality Register. A strict definition of permanent hypoparathyroidism was used, including biochemical data and attempts to stop the treatment.ResultsA total of 1636 patients were included. Altogether, 143 patients (8.7 per cent) developed permanent hypoparathyroidism. Of these, 102 (6.2 per cent) had definitive permanent hypoparathyroidism, whereas 41 (2.5 per cent) had possible permanent hypoparathyroidism, because attempts to stop the treatment were lacking (28) or patients were lost to follow-up (13). The agreement between the Swedish Quality Register and the chart review was 29.3 per cent. A proportion of 23.2 per cent with a PTH level below the reference value corresponded to a 6.7 per cent rate of permanent hypoparathyroidism.ConclusionThe risk of permanent hypoparathyroidism after total thyroidectomy is high. Some patients are overtreated because attempts to stop the treatment are lacking. Quality registers might underestimate the risk of permanent hypoparathyroidism. Approximately one-quarter of all patients with low PTH levels immediately after surgery developed permanent hypoparathyroidism. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kirurgi0 (SwePub)302122 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Surgery0 (SwePub)302122 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng |
653 | a Thyroidectomy | |
653 | a hypoparathyroidism | |
653 | a parathyroid hormone | |
653 | a quality register | |
653 | a Surgery | |
653 | a Kirurgi | |
700 | 1 | a Osterman, Carolina4 aut |
700 | 1 | a Arlebrink, Jesper4 aut |
700 | 1 | a Mellerstedt, Simon4 aut |
700 | 1 | a Papathanasakis, Nicolas4 aut |
700 | 1 | a Wallin, Göran4 aut |
700 | 1 | a Hessman, Ola4 aut |
700 | 1 | a Annerbo, Maria4 aut |
700 | 1 | a Norlén, Olovu Uppsala universitet,Endokrinkirurgi4 aut0 (Swepub:uu)olono376 |
710 | 2 | a Uppsala universitetb Endokrinkirurgi4 org |
773 | 0 | t British Journal of Surgeryd : Oxford University Pressg 111:1q 111:1x 0007-1323x 1365-2168 |
856 | 4 | u https://doi.org/10.1093/bjs/znad366y Fulltext |
856 | 4 | u https://uu.diva-portal.org/smash/get/diva2:1738819/FULLTEXT02.pdfx primaryx Raw objecty fulltext:print |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-497029 |
856 | 4 8 | u https://doi.org/10.1093/bjs/znad366 |
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