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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04251naa a2200493 4500 | |
| 001 | oai:DiVA.org:uu-498563 | |
| 003 | SwePub | |
| 008 | 230317s2023 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4985632 URI |
| 024 | 7 | a https://doi.org/10.3390/cancers150410822 DOI |
| 040 | a (SwePub)uu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Lin, Chun-Yuu Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Kaohsiung Med Univ, Coll Med, Ctr Trop Med & Infect Dis Res, Div Infect Dis,Dept Internal Med,Kaohsiung Med Uni, Kaohsiung 807, Taiwan.4 aut0 (Swepub:uu)chuli862 |
| 245 | 1 0 | a Hyaluronan-Induced CD44-iASPP Interaction Affects Fibroblast Migration and Survival |
| 264 | c 2023-02-08 | |
| 264 | 1 | b MDPI,c 2023 |
| 338 | a electronic2 rdacarrier | |
| 500 | a De två första författarna delar förstaförfattarskapet. | |
| 520 | a In the present study, we show that the inhibitor of the apoptosis-stimulating protein of p53 (iASPP) physically interacts with the hyaluronan receptor CD44 in normal and transformed cells. We noticed that the CD44 standard isoform (CD44s), but not the variant isoform (CD44v), bound to iASPP via the ankyrin-binding domain in CD44s. The formation of iASPP-CD44s complexes was promoted by hyaluronan stimulation in fibroblasts but not in epithelial cells. The cellular level of p53 affected the amount of the iASPP-CD44 complex. iASPP was required for hyaluronan-induced CD44-dependent migration and adhesion of fibroblasts. Of note, CD44 altered the sub-cellular localization of the iASPP-p53 complex; thus, ablation of CD44 promoted translocation of iASPP from the nucleus to the cytoplasm, resulting in increased formation of a cytoplasmic iASPP-p53 complex in fibroblasts. Overexpression of iASPP decreased, but CD44 increased the level of intracellular reactive oxygen species (ROS). Knock-down of CD44s, in the presence of p53, led to increased cell growth and cell density of fibroblasts by suppression of p27 and p53. Our observations suggest that the balance of iASPP-CD44 and iASPP-p53 complexes affect the survival and migration of fibroblasts. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Cell- och molekylärbiologi0 (SwePub)301082 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Cell and Molecular Biology0 (SwePub)301082 hsv//eng |
| 653 | a CD44 | |
| 653 | a p53 | |
| 653 | a iASPP | |
| 653 | a hyaluronan | |
| 653 | a apoptosis | |
| 653 | a cancer | |
| 653 | a tumor microenvironment | |
| 700 | 1 | a Basu, Kaustuvu Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,McGill Univ, Dept Mech Engn, Montreal, PQ H3A 0C3, Canada.4 aut0 (Swepub:uu)kauba470 |
| 700 | 1 | a Ruusala, Ainou Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi4 aut0 (Swepub:uu)ainoruus |
| 700 | 1 | a Kozlova, Innau Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi4 aut0 (Swepub:uu)innakozl |
| 700 | 1 | a Li, Yan-Shuangu Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Capital Med Univ, Beijing Chaoyang Hosp, Dept Breast Surg, Beijing 100020, Peoples R China.4 aut |
| 700 | 1 | a Skandalis, Spyridon S.u Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Univ Patras, Dept Chem, Lab Biochem, Patras 26504, Greece.4 aut |
| 700 | 1 | a Heldin, Carl-Henrik,d 1952-u Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi4 aut0 (Swepub:uu)carlheld |
| 700 | 1 | a Heldin, Paraskeviu Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi4 aut0 (Swepub:uu)paraheld |
| 710 | 2 | a Uppsala universitetb Institutionen för medicinsk biokemi och mikrobiologi4 org |
| 773 | 0 | t Cancersd : MDPIg 15:4q 15:4x 2072-6694 |
| 856 | 4 | u https://doi.org/10.3390/cancers15041082y Fulltext |
| 856 | 4 | u https://uu.diva-portal.org/smash/get/diva2:1744188/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-498563 |
| 856 | 4 8 | u https://doi.org/10.3390/cancers15041082 |
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