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Pre-pregnancy compl...
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Gudnadottir, UnnurKarolinska Institutet
(author)
Pre-pregnancy complications-associated factors and wellbeing in early pregnancy : a Swedish cohort study
- Article/chapterEnglish2023
Publisher, publication year, extent ...
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2023-03-08
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BioMed Central (BMC),2023
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electronicrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-499931
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-499931URI
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https://doi.org/10.1186/s12884-023-05479-8DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:152168760URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Background: Many couples experience difficulties to become pregnant or carry a pregnancy to term due to unknown causes. Here we define pre-pregnancy complications as having prior recurrent pregnancy loss, prior late miscarriages, time to pregnancy more than one year, or the use of artificial reproductive technologies. We aim to identify factors associated with pre-pregnancy complications and poor well-being in early pregnancy.Methods: Online questionnaire data from 5330 unique pregnancies in Sweden were collected from November 2017 - February 2021. Multivariable logistic regression modelling was used to investigate potential risk factors for pre-pregnancy complications and differences in early pregnancy symptoms.Results: Pre-pregnancy complications were identified in 1142 participants (21%). Risk factors included diagnosed endometriosis, thyroid medication, opioids and other strong pain medication, body mass index > 25 kg/m(2) and age over 35 years. Different subgroups of pre-pregnancy complications had unique risk factors. The groups also experienced different pregnancy symptoms in early pregnancy, where women that had experienced recurrent pregnancy loss were at higher risk of depression in their current pregnancy.Conclusion: We report one of the largest pregnancy cohorts with high frequency of pre-pregnancy complications compared to the Swedish population. Prescribed drug use and body weight were the top potentially modifiable risk factors in all groups. Participants that experienced pre-pregnancy complications also had higher risk of depression and pregnancy problems in early pregnancy.
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Du, JuanKarolinska Institutet
(author)
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Hugerth, Luisa W. W.Karolinska Institutet,Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Karolinska Inst, Ctr Translat Microbiome Res, Dept Microbiol Tumor & Cell Biol MTC, S-17165 Solna, Sweden.(Swepub:uu)luiwa518
(author)
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Engstrand, LarsKarolinska Inst, Ctr Translat Microbiome Res, Dept Microbiol Tumor & Cell Biol MTC, S-17165 Solna, Sweden.
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Schuppe-Koistinen, InaKarolinska Institutet
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Itzel, Eva WibergSoder Sjukhuset, Dept Clin Sci & Educ, Stockholm, Sweden.
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Fransson, Emma,PhD,1973-Karolinska Institutet,Uppsala universitet,Obstetrisk och reproduktiv hälsoforskning,Karolinska Inst, Ctr Translat Microbiome Res, Dept Microbiol Tumor & Cell Biol MTC, S-17165 Solna, Sweden.(Swepub:uu)emmfr204
(author)
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Brusselaers, NeleKarolinska Institutet
(author)
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Karolinska InstitutetInstitutionen för medicinsk biokemi och mikrobiologi
(creator_code:org_t)
Related titles
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In:BMC Pregnancy and Childbirth: BioMed Central (BMC)231471-23931471-2393
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