Cardiovascular disease-linked plasma proteins are mainly associated with lung volume

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Cardiovascular disease-linked plasma proteins are mainly associated with lung volume

Rydell, Andreas (author): Karolinska Institutet,Karolinska Institute

Nerpin, Elisabet, 1962- (author): Dalarna University College,Högskolan Dalarna,Uppsala universitet,Lung- allergi- och sömnforskning,School of Health and Welfare, Dalarna University,Medicinsk vetenskap,Uppsala University, Uppsala

Zhou, Xingwu (author): Uppsala universitet,Institutionen för medicinska vetenskaper,Uppsala University, Uppsala

Lind, Lars (author): Uppsala universitet,Klinisk epidemiologi,Uppsala University, Uppsala

Lindberg, Eva (author): Uppsala universitet,Lung- allergi- och sömnforskning,Uppsala University, Uppsala

Theorell-Haglöw, Jenny (author): Uppsala universitet,Lung- allergi- och sömnforskning,Uppsala University, Uppsala

Fall, Tove, 1979- (author): Uppsala universitet,Molekylär epidemiologi,Uppsala University, Uppsala

Janson, Christer (author): Uppsala universitet,Lung- allergi- och sömnforskning,Uppsala University, Uppsala

Lisspers, Karin, Docent, 1954- (author): Uppsala universitet,Allmänmedicin och preventivmedicin,Uppsala University, Uppsala

Elmståhl, Sölve (author): Lund University,Lunds universitet,Geriatrik,Forskargrupper vid Lunds universitet,Geriatrics,Lund University Research Groups

Zaigham, Suneela (author): Lund University,Lunds universitet,Uppsala universitet,Klinisk fysiologi,Department of Clinical Sciences, Lund University,Uppsala University, Uppsala; Lund University, Malmö,Kardiovaskulär forskning - epidemiologi,Forskargrupper vid Lunds universitet,Cardiovascular Research - Epidemiology,Lund University Research Groups

Melander, Olle (author): Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups,Skåne University Hospital

Nilsson, Peter M. (author): Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups

Ärnlöv, Johan, 1970- (author): Karolinska Institute,Dalarna University College,Högskolan Dalarna,Medicinsk vetenskap,Karolinska Institutet, Huddinge; Region Dalarna, Falun

Malinovschi, Andrei, 1978- (author): Uppsala universitet,Klinisk fysiologi,Uppsala University, Uppsala

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2023-01-26
2023
English.
In: ERJ Open Research. - : European Respiratory Society. - 2312-0541. ; 9:2

Related links:: https://doi.org/10.1...; show more...; https://uu.diva-port... (primary) (Raw object); https://du.diva-port... (primary) (Raw object); http://dx.doi.org/10... (free); https://urn.kb.se/re...; https://doi.org/10.1...; https://urn.kb.se/re...; https://lup.lub.lu.s...; http://kipublication...; show less...

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BACKGROUND: Epidemiological studies have shown that impaired lung function is common and associated with increased risk of cardiovascular disease. Increased levels of several inflammatory and cardiovascular disease-related plasma proteins have been associated with impaired lung function. The aim was to study the association between plasma proteomics and forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC) and FEV1/FVC ratio.METHODS: We used a discovery and replication approach in two community-based cohorts, EpiHealth and the Malmö Offspring Study (total n=2874), to cross-sectionally study 242 cardiovascular disease- and metabolism-linked proteins in relation to FEV1, FVC (both % predicted) and FEV1/FVC ratio. A false discovery rate of 5% was used as the significance threshold in the discovery cohort.RESULTS: Plasma fatty acid-binding protein 4, interleukin-1 receptor antagonist, interleukin-6 and leptin were negatively associated with FEV1 and paraoxonase 3 was positively associated therewith. Fatty acid-binding protein 4, fibroblast growth factor 21, interleukin-1 receptor antagonist, interleukin-6 and leptin were negatively associated with FVC and agouti-related protein, insulin-like growth factor-binding protein 2, paraoxonase 3 and receptor for advanced glycation end products were positively associated therewith. No proteins were associated with FEV1/FVC ratio. A sensitivity analysis in EpiHealth revealed only minor changes after excluding individuals with known cardiovascular disease, diabetes or obesity.CONCLUSIONS: Five proteins were associated with both FEV1 and FVC. Four proteins associated with only FVC and none with FEV1/FVC ratio, suggesting associations mainly through lung volume, not airway obstruction. However, additional studies are needed to investigate underlying mechanisms for these findings.

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By the author/editor: Rydell, Andreas; Nerpin, Elisabet ...; Zhou, Xingwu; Lind, Lars; Lindberg, Eva; Theorell-Haglöw, ...; show more...; Fall, Tove, 1979 ...; Janson, Christer; Lisspers, Karin, ...; Elmståhl, Sölve; Zaigham, Suneela; Melander, Olle; Nilsson, Peter M ...; Ärnlöv, Johan, 1 ...; Malinovschi, And ...; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Respiratory Medi ...

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cardiac and Card ...

Articles in the publication: ERJ Open Researc ...

By the university: Uppsala University; Högskolan Dalarna; Lund University; Karolinska Institutet

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Cardiovascular disease-linked plasma proteins are mainly associated with lung volume

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