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An atlas of genetic...
An atlas of genetic scores to predict multi-omic traits
- Article/chapterEnglish2023
Publisher, publication year, extent ...
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2023-03-29
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Springer Nature,2023
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-500879
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-500879URI
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https://doi.org/10.1038/s41586-023-05844-9DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:152565484URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:155150411URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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The use of omic modalities to dissect the molecular underpinnings of common diseases and traits is becoming increasingly common. But multi-omic traits can be genetically predicted, which enables highly cost-effective and powerful analyses for studies that do not have multi-omics1. Here we examine a large cohort (the INTERVAL study2; n = 50,000 participants) with extensive multi-omic data for plasma proteomics (SomaScan, n = 3,175; Olink, n = 4,822), plasma metabolomics (Metabolon HD4, n = 8,153), serum metabolomics (Nightingale, n = 37,359) and whole-blood Illumina RNA sequencing (n = 4,136), and use machine learning to train genetic scores for 17,227 molecular traits, including 10,521 that reach Bonferroni-adjusted significance. We evaluate the performance of genetic scores through external validation across cohorts of individuals of European, Asian and African American ancestries. In addition, we show the utility of these multi-omic genetic scores by quantifying the genetic control of biological pathways and by generating a synthetic multi-omic dataset of the UK Biobank3 to identify disease associations using a phenome-wide scan. We highlight a series of biological insights with regard to genetic mechanisms in metabolism and canonical pathway associations with disease; for example, JAK-STAT signalling and coronary atherosclerosis. Finally, we develop a portal ( https://www.omicspred.org/ ) to facilitate public access to all genetic scores and validation results, as well as to serve as a platform for future extensions and enhancements of multi-omic genetic scores.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Ritchie, Scott C
(author)
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Liang, Yujian
(author)
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Timmers, Paul R H J
(author)
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Pietzner, Maik
(author)
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Lannelongue, Loïc
(author)
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Lambert, Samuel A
(author)
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Tahir, Usman A
(author)
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May-Wilson, Sebastian
(author)
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Foguet, Carles
(author)
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Johansson, ÅsaUppsala universitet,Institutionen för immunologi, genetik och patologi,Science for Life Laboratory, SciLifeLab(Swepub:uu)asjoh108
(author)
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Surendran, Praveen
(author)
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Nath, Artika P
(author)
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Persyn, Elodie
(author)
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Peters, James E
(author)
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Oliver-Williams, Clare
(author)
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Deng, Shuliang
(author)
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Prins, Bram
(author)
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Luan, Jian'an
(author)
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Bomba, Lorenzo
(author)
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Soranzo, Nicole
(author)
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Di Angelantonio, Emanuele
(author)
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Pirastu, Nicola
(author)
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Tai, E Shyong
(author)
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van Dam, Rob M
(author)
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Parkinson, Helen
(author)
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Davenport, Emma E
(author)
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Paul, Dirk S
(author)
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Yau, Christopher
(author)
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Gerszten, Robert E
(author)
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Mälarstig, Anders
(author)
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Danesh, John
(author)
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Sim, Xueling
(author)
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Langenberg, Claudia
(author)
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Wilson, James F
(author)
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Butterworth, Adam S
(author)
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Inouye, Michael
(author)
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Uppsala universitetInstitutionen för immunologi, genetik och patologi
(creator_code:org_t)
Related titles
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In:Nature: Springer Nature616:7955, s. 123-1310028-08361476-4687
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- By the author/editor
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Xu, Yu
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Ritchie, Scott C
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Liang, Yujian
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Timmers, Paul R ...
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Pietzner, Maik
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Lannelongue, Loï ...
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show more...
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Lambert, Samuel ...
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Tahir, Usman A
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May-Wilson, Seba ...
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Foguet, Carles
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Johansson, Åsa
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Surendran, Prave ...
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Nath, Artika P
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Persyn, Elodie
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Peters, James E
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Oliver-Williams, ...
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Deng, Shuliang
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Prins, Bram
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Luan, Jian'an
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Bomba, Lorenzo
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Soranzo, Nicole
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Di Angelantonio, ...
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Pirastu, Nicola
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Tai, E Shyong
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van Dam, Rob M
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Parkinson, Helen
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Davenport, Emma ...
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Paul, Dirk S
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Yau, Christopher
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Gerszten, Robert ...
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Mälarstig, Ander ...
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Danesh, John
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Sim, Xueling
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Langenberg, Clau ...
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Wilson, James F
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Butterworth, Ada ...
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Inouye, Michael
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
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Nature
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Uppsala University
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Karolinska Institutet