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European Neuroendoc...
European Neuroendocrine Tumor Society (ENETS) 2023 guidance paper for digestive neuroendocrine carcinoma
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- Sorbye, Halfdan (author)
- Haukeland Hosp, Dept Oncol, Bergen, Norway.;Univ Bergen, Dept Clin Sci, Bergen, Norway.;Haukeland Hosp, Dept Oncol, N-5021 Bergen, Norway.
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- Grande, Enrique (author)
- MD Anderson Canc Ctr Madrid, Dept Med Oncol, Madrid, Spain.
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- Pavel, Marianne (author)
- Friedrich Alexander Univ Erlangen Nurnberg, Dept Med 1, Erlangen, Germany.
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- Tesselaar, Margot (author)
- Netherlands Canc Inst, Dept Gastrointestinal Oncol, Amsterdam, Netherlands.
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- Fazio, Nicola (author)
- European Inst Oncol, Div Gastrointestinal Med Oncol & Neuroendocrine Tu, IEO, IRCCS, Milan, Italy.
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- Reed, Nicholas Simon (author)
- Beatson Oncol Ctr, Dept Clin Oncol, Glasgow City, Scotland.
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- Knigge, Ulrich (author)
- Copenhagen Univ Hosp, Rigshospitalet, ENETS Ctr Excellence, Dept Surg & Clin Endocrinol, Copenhagen, Denmark.
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- Christ, Emanuel (author)
- Univ Hosp Basel, ENETS Ctr Excellence, Dept Endocrinol Diabet & Metab, Basel, Switzerland.
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- Ambrosini, Valentina (author)
- Univ Bologna, Nucl Med, Alma Mater Studiorum, Bologna, Italy.;Azienda Osped Univ Bologna, IRCCS, Bologna, Italy.
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- Couvelard, Anne (author)
- Univ Paris Cite, Bichat Hosp, AP HP, Dept Pathol, Paris, France.
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- Tiensuu Janson, Eva (author)
- Uppsala universitet,Onkologisk endokrinologi
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Haukeland Hosp, Dept Oncol, Bergen, Norway;Univ Bergen, Dept Clin Sci, Bergen, Norway.;Haukeland Hosp, Dept Oncol, N-5021 Bergen, Norway. MD Anderson Canc Ctr Madrid, Dept Med Oncol, Madrid, Spain. (creator_code:org_t)
- 2023-03-16
- 2023
- English.
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In: Journal of neuroendocrinology. - : John Wiley & Sons. - 0953-8194 .- 1365-2826. ; 35:3
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Abstract
Subject headings
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- This ENETS guidance paper, developed by a multidisciplinary working group, provides up-to-date and practical advice on the diagnosis and management of digestive neuroendocrine carcinoma, based on recent developments and study results. These recommendations aim to pave the road for more standardized care for our patients resulting in improved outcomes. Prognosis is generally poor for digestive NEC, most are advanced at diagnosis and median survival in metastatic disease is 11-12 months. Surgery can be of benefit for localized disease after extensive preoperative imaging. Carboplatin in combination with etoposide is recommended as first-line treatment for metastatic disease. Irinotecan with fluoropyrimidines has the best evidence as second-line treatment. Immunotherapy plays a minor role in biomarker-unselected patients. Molecular profiling if available is encouraged to identify new targets. More prospective clinical trials are highly needed to fulfil the unmet needs in this field, especially on new predictive and prognostic biomarkers and to improve survival of patients with advanced disease.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
Keyword
- diagnosis
- digestive
- NEC
- neuroendocrine carcinoma
- neuroendocrine neoplasms
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Sorbye, Halfdan
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Grande, Enrique
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Pavel, Marianne
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Tesselaar, Margo ...
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Fazio, Nicola
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Reed, Nicholas S ...
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Knigge, Ulrich
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Christ, Emanuel
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Ambrosini, Valen ...
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Couvelard, Anne
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Tiensuu Janson, ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
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MEDICAL AND HEAL ...
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Journal of neuro ...
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Uppsala University