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New and Repurposed ...
New and Repurposed Drugs for the Treatment of Active Tuberculosis : An Update for Clinicians
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- Diaz, Jessica M. Aguilar (author)
- Radboud Univ Nijmegen, Med Ctr, Radboudumc Ctr Infect Dis, TB Expert Ctr Dekkerswald,Dept Pulm Dis, Nijmegen, Netherlands.
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- Abulfathi, Ahmed A. (author)
- Univ Florida, Ctr Pharmacometr & Syst Pharmacol, Dept Pharmaceut, Gainesville, FL USA.;Univ Maiduguri, Coll Med Sci, Fac Basic Clin Sci, Dept Clin Pharmacol & Therapeut, Maiduguri, Nigeria.;Stellenbosch Univ, Fac Med & Hlth Sci, Dept Med, Div Clin Pharmacol, Cape Town, South Africa.
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- te Brake, Lindsey H. M. (author)
- Radboud Univ Nijmegen, Med Ctr, Radboudumc Ctr Infect Dis, Radboud Inst Hlth Sci,Dept Pharm, Nijmegen, Netherlands.
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- van Ingen, Jakko (author)
- Radboud Univ Nijmegen, Med Ctr, Radboudumc Ctr Infect Dis, Dept Med Microbiol, Nijmegen, Netherlands.
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- Kuipers, Saskia (author)
- Radboud Univ Nijmegen, Med Ctr, Radboudumc Ctr Infect Dis, Dept Med Microbiol, Nijmegen, Netherlands.
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- Magis-Escurra, Cecile (author)
- Radboud Univ Nijmegen, Med Ctr, Radboudumc Ctr Infect Dis, TB Expert Ctr Dekkerswald,Dept Pulm Dis, Nijmegen, Netherlands.
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- Raaijmakers, Jelmer (author)
- Radboud Univ Nijmegen, Med Ctr, Radboudumc Ctr Infect Dis, Dept Med Microbiol, Nijmegen, Netherlands.
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- Svensson, Elin, 1985- (author)
- Uppsala universitet,Institutionen för farmaci,Radboud Univ Nijmegen, Med Ctr, Radboudumc Ctr Infect Dis, Radboud Inst Hlth Sci,Dept Pharm, Nijmegen, Netherlands.
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- Boeree, Martin J. (author)
- Radboud Univ Nijmegen, Med Ctr, Radboudumc Ctr Infect Dis, TB Expert Ctr Dekkerswald,Dept Pulm Dis, Nijmegen, Netherlands.
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Radboud Univ Nijmegen, Med Ctr, Radboudumc Ctr Infect Dis, TB Expert Ctr Dekkerswald,Dept Pulm Dis, Nijmegen, Netherlands Univ Florida, Ctr Pharmacometr & Syst Pharmacol, Dept Pharmaceut, Gainesville, FL USA.;Univ Maiduguri, Coll Med Sci, Fac Basic Clin Sci, Dept Clin Pharmacol & Therapeut, Maiduguri, Nigeria.;Stellenbosch Univ, Fac Med & Hlth Sci, Dept Med, Div Clin Pharmacol, Cape Town, South Africa. (creator_code:org_t)
- 2022-12-14
- 2023
- English.
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In: Respiration. - : S. Karger. - 0025-7931 .- 1423-0356. ; 102:2, s. 83-100
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Abstract
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- Although tuberculosis (TB) is preventable and curable, the lengthy treatment (generally 6 months), poor patient adherence, high inter-individual variability in pharmacokinetics (PK), emergence of drug resistance, presence of comorbidities, and adverse drug reactions complicate TB therapy and drive the need for new drugs and/or regimens. Hence, new compounds are being developed, available drugs are repurposed, and the dosing of existing drugs is optimized, resulting in the largest drug development portfolio in TB history. This review highlights a selection of clinically available drug candidates that could be part of future TB regimens, including bedaquiline, delamanid, pretomanid, linezolid, clofazimine, optimized (high dose) rifampicin, rifapentine, and para-aminosalicylic acid. The review covers drug development history, preclinical data, PK, and current clinical development.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmaceutiska vetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmaceutical Sciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)
Keyword
- Drugs
- Treatment
- Tuberculosis
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- By the author/editor
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Diaz, Jessica M. ...
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Abulfathi, Ahmed ...
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te Brake, Lindse ...
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van Ingen, Jakko
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Kuipers, Saskia
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Magis-Escurra, C ...
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Raaijmakers, Jel ...
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Svensson, Elin, ...
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Boeree, Martin J ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Pharmaceutical S ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Pharmacology and ...
- Articles in the publication
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Respiration
- By the university
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Uppsala University