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Individual net clin...
Individual net clinical outcome with oral anticoagulation in atrial fibrillation using the ABC-AF risk scores
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- Hijazi, Ziad (author)
- Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Kardiologi
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- Lindbäck, Johan (author)
- Uppsala universitet,Uppsala kliniska forskningscentrum (UCR)
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- Oldgren, Jonas, 1964- (author)
- Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR)
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- Benz, Alexander P. (author)
- Populat Hlth Res Inst, Hamilton, ON, Canada.;Johannes Gutenberg Univ Mainz, Univ Med Ctr Mainz, Dept Cardiol, Cardiol 1, Mainz, Germany.
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- Alexander, John H. (author)
- Duke Clin Res Inst, Duke Med, Durham, NC USA.
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- Connolly, Stuart J. (author)
- Populat Hlth Res Inst, Hamilton, ON, Canada.
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- Eikelboom, John W. (author)
- Populat Hlth Res Inst, Hamilton, ON, Canada.
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- Granger, Christopher B. (author)
- Duke Clin Res Inst, Duke Med, Durham, NC USA.
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- Lopes, Renato D. (author)
- Duke Clin Res Inst, Duke Med, Durham, NC USA.
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- Siegbahn, Agneta, 1947- (author)
- Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Klinisk kemi
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- Wallentin, Lars, 1943- (author)
- Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR)
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(creator_code:org_t)
- Elsevier, 2023
- 2023
- English.
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In: American Heart Journal. - : Elsevier. - 0002-8703 .- 1097-6744. ; 261, s. 55-63
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Abstract
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- BackgroundDecisions on stroke prevention strategies in patients with atrial fibrillation (AF) depend on the perceived risks of stroke and bleeding with different antithrombotic treatment strategies. The study objectives were to evaluate net clinical outcome with oral anticoagulation (OAC) for the individual patient with AF and to identify clinically relevant thresholds for OAC treatment.MethodsPatients with AF receiving OAC treatment in the randomized ARISTOTLE and RE-LY trials, with available biomarkers for calculation of ABC-AF scores at baseline, were included (n = 23,121). Observed 1-year risk on OAC was compared with predicted 1-year risk if the same patients would not have received OAC using the ABC-AF scores calibrated for aspirin. Net clinical outcome was defined as the sum of stroke and major bleeding risks.ResultsThe ratio between the 1-year incidence of major bleeding and stroke/systemic embolism events ranged from 1.4 to 10.6 according to different ABC-AF risk profiles. Net clinical outcome analyses showed that in patients with an ABC-AF-stroke risk >1% per year on OAC (>3% without OAC), treatment with OAC consistently provides larger net clinical benefit than no-OAC treatment. In patients with an ABC-AF-stroke risk <1.0% per year on OAC (<3% without OAC) an individualized balancing of risks regarding OAC or no-OAC treatment is needed.ConclusionsIn patients with AF, the ABC-AF risk scores allow an individual and continuous estimate of the balance between benefits and risks with OAC treatment. This precision medicine tool therefore seems useful as decision support and visualizes the net clinical benefit or harm with OAC treatment (http://www.abc-score.com/abcaf/).Clinical Trial RegistrationClinicalTrials.gov identifier NCT00412984 (ARISTOTLE) and NCT00262600 (RE-LY).
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
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- ref (subject category)
- art (subject category)
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Hijazi, Ziad
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Lindbäck, Johan
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Oldgren, Jonas, ...
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Benz, Alexander ...
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Alexander, John ...
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Connolly, Stuart ...
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Eikelboom, John ...
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Granger, Christo ...
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Lopes, Renato D.
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Siegbahn, Agneta ...
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Wallentin, Lars, ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
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American Heart J ...
- By the university
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Uppsala University