Challenges and shortcomings of antibacterial discovery projects

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Theuretzbacher, UrsulaCtr Anti Infect Agents, Vienna, Austria.;Ctr Antiinfect Agents, A-1180 Vienna, Austria. (author)

Challenges and shortcomings of antibacterial discovery projects

Article/chapterEnglish2023

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Elsevier,2023
electronicrdacarrier

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LIBRIS-ID:oai:DiVA.org:uu-503108
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-503108URI
https://doi.org/10.1016/j.cmi.2022.11.027DOI

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Language:English
Summary in:English

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Subject category:art swepub-publicationtype

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ObjectivesAntibacterial drug discovery activities are essential for filling clinical pipelines with promising clinical candidates. Little information is available about the challenges and shortcomings of small companies and academic institutions in performing these important discovery tasks.MethodsWe performed a content analysis of 463 reviewer comments on 91 funding applications of antibacterial drug discovery projects submitted to two major global funders between 2016 and 2020 that had not proceeded further in the selection process. This quality assessment was complemented with the inputs (via e-mail) from a panel involving six antibiotic research and development (R&D) experts with long-standing expertise and experience in antibiotic drug discovery.ResultsCommon critical comments of reviewers are grouped into three main categories: scientific and technical shortcomings, unclear potential societal impact, and insufficient capability and expertise of the project team regarding the R&D process. Insufficient characterization of in vitro activity and/or testing of the hits/leads and insufficient antibacterial activity were the most common critical comments. Other areas of concern were insufficient or lack of differentiation from available drugs or projects with a long R&D history, and the research team's insufficient knowledge of a structured streamlined R&D process as reflected in severe gaps in the expertise of the R&D team. Little appreciation for the problem of the emergence of target-based resistance, especially in single-target approaches, and little awareness of toxicological issues, including approaches with historical liabilities were also commonly mentioned. The shortcomings identified through the analysis of funding applications are echoed by the results of the expert panel.DiscussionOur analysis identified an urgent need of strengthening the support for antibacterial drug discovery teams to help more projects reach such a quality to be eligible for global funders and private investors.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Infektionsmedicin hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Infectious Medicine hsv//eng
NATURVETENSKAP Data- och informationsvetenskap Annan data- och informationsvetenskap hsv//swe
NATURAL SCIENCES Computer and Information Sciences Other Computer and Information Science hsv//eng
Antibiotics
Antibacterial pipelines
Drug discovery
Expert panel
Funding applications

Added entries (persons, corporate bodies, meetings, titles ...)

Baraldi, Enrico,Professor,1970-Uppsala universitet,Industriell teknik(Swepub:uu)enribara (author)
Ciabuschi, Francesco,1973-Uppsala universitet,Företagsekonomiska institutionen(Swepub:uu)frcia027 (author)
Callegari, Simone,PhD,1981-Uppsala universitet,Institutionen för informatik och media(Swepub:uu)simca287 (author)
Ctr Anti Infect Agents, Vienna, Austria.;Ctr Antiinfect Agents, A-1180 Vienna, Austria.Industriell teknik (creator_code:org_t)

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In:Clinical Microbiology and Infection: Elsevier29:5, s. 610-6151198-743X1469-0691

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