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Ephedrine to treat ...
Ephedrine to treat intraoperative hypotension in infants : what is the target?
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- de Graaff, Jurgen C. (author)
- Erasmus MC, Dept Anaesthesiol, ADRZ, Goes, Netherlands
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- Frykholm, Peter, 1961- (author)
- Uppsala universitet,Anestesiologi och intensivvård
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(creator_code:org_t)
- Elsevier, 2023
- 2023
- English.
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In: British Journal of Anaesthesia. - : Elsevier. - 0007-0912 .- 1471-6771. ; 130:5, s. 510-515
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Off-label use of medications in paediatric anaesthesia is common practice, owing to the relative paucity of evidence -based dosing regimens in children. Well-performed dose-finding studies, especially in infants, are rare and urgently needed. Unanticipated effects can result when paediatric dosing is based on adult parameters or local traditions. A recent dose-finding study on ephedrine highlights the uniqueness of paediatric dosing in comparison with adult dosing. We discuss the problems of off-label medication use and the lack of evidence for various definitions of hypotension and associated treatment strategies in paediatric anaesthesia. What is the aim of treating hypotension associated with anaesthesia induction: restoring the MAP to awake baseline values or elevating it above a provisional hypotension threshold?
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Anestesi och intensivvård (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Anesthesiology and Intensive Care (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
Keyword
- encephalopathy
- ephedrine
- hypotension
- off-label use
- paediatric anaesthesia
Publication and Content Type
- vet (subject category)
- art (subject category)
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