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Comparative Analysis of the Humoral Immune Response to the EBV Proteome across EBV-Related Malignancies

Argirion, Ilona (author)
NCI, Div Canc Epidemiol & Genet, Rockville, MD USA.
Pfeiffer, Ruth M. (author)
NCI, Div Canc Epidemiol & Genet, Rockville, MD USA.
Proietti, Carla (author)
James Cook Univ, Australian Inst Trop Hlth & Med, Ctr Mol Therapeut, Cairns, Qld, Australia.
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Coghill, Anna E. (author)
NCI, Div Canc Epidemiol & Genet, Rockville, MD USA.;H Lee Moffitt Canc Ctr & Res Inst, Canc Epidemiol Program, Div Populat Sci, Tampa, FL USA.
Yu, Kelly J. (author)
NCI, Div Canc Epidemiol & Genet, Rockville, MD USA.
Middeldorp, Jaap M. (author)
Vrije Univ Amsterdam Med Ctr, Amsterdam, Netherlands.
Sarathkumara, Yomani D. (author)
James Cook Univ, Australian Inst Trop Hlth & Med, Ctr Mol Therapeut, Cairns, Qld, Australia.
Hsu, Wan-Lun (author)
Fu Jen Catholic Univ, Coll Med, Master Program Big Data Biomed, New Taipei, Taiwan.;Fu Jen Catholic Univ, Coll Med, Data Sci Ctr, New Taipei, Taiwan.
Chien, Yin-Chu (author)
Acad Sinica, Genom Res Ctr, Taipei, Taiwan.;Natl Hlth Res Inst, Natl Inst Canc Res, Miaoli, Taiwan.
Lou, Pei-Jen (author)
Natl Taiwan Univ Hosp & Coll Med, Dept Otolaryngol, Taipei, Taiwan.
Wang, Cheng-Ping (author)
Natl Taiwan Univ Hosp & Coll Med, Dept Otolaryngol, Taipei, Taiwan.
Rothman, Nathaniel (author)
NCI, Div Canc Epidemiol & Genet, Rockville, MD USA.
Lan, Qing (author)
NCI, Div Canc Epidemiol & Genet, Rockville, MD USA.
Chen, Chien-Jen (author)
Acad Sinica, Genom Res Ctr, Taipei, Taiwan.;Natl Taiwan Univ, Grad Inst Epidemiol & Prevent Med, Coll Publ Hlth, Taipei, Taiwan.
Mbulaiteye, Sam M. (author)
NCI, Div Canc Epidemiol & Genet, Rockville, MD USA.
Jarrett, Ruth F. (author)
Univ Glasgow, MRC, Ctr Virus Res, Glasgow, Lanark, Scotland.
Glimelius, Ingrid, 1975- (author)
Karolinska Institutet,Uppsala universitet,Institutionen för immunologi, genetik och patologi
Smedby, Karin E. (author)
Karolinska Institutet
Hjalgrim, Henrik (author)
Statens Serum Inst, Copenhagen, Denmark.;Rigshosp, Dept Haematol, Copenhagen, Denmark.
Hildesheim, Allan (author)
NCI, Div Canc Epidemiol & Genet, Rockville, MD USA.
Doolan, Denise L. (author)
James Cook Univ, Australian Inst Trop Hlth & Med, Ctr Mol Therapeut, Cairns, Qld, Australia.
Liu, Zhiwei (author)
NCI, Div Canc Epidemiol & Genet, Rockville, MD USA.
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NCI, Div Canc Epidemiol & Genet, Rockville, MD USA James Cook Univ, Australian Inst Trop Hlth & Med, Ctr Mol Therapeut, Cairns, Qld, Australia. (creator_code:org_t)
American Association For Cancer Research (AACR), 2023
2023
English.
In: Cancer Epidemiology, Biomarkers and Prevention. - : American Association For Cancer Research (AACR). - 1055-9965 .- 1538-7755. ; 32:5, s. 687-696
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  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Background: Epstein-Barr virus (EBV) is linked to multiple cancers, including classical Hodgkin lymphoma (cHL), endemic Burkitt lymphoma (eBL), nasopharyngeal carcinoma (NPC), and extranodal natural killer/T-cell lymphoma (NKTCL).Methods: Anti-EBV IgG and IgA antibody responses target-ing 202 sequences from 86 EBV proteins were measured using the same EBV whole proteome array across four case-control studies investigating EBV-positive cHL, eBL, NPC, and NKTCL (407 cases/620 controls). We grouped EBV-targeted antibodies into pathways by immunoglobulin type (IgA and IgG) and life-cycle stage (latent, immediate early lytic, early lytic, late lytic, and glycoprotein) and evaluated their associ-ation with each cancer type. In an additional analysis, we focused on the subset of 46 individual antibodies repre-senting the top candidates for each cancer and compared their associations across the four cancer types using multivariable linear regression models.Results: IgA antibody responses targeting all EBV life-cycle stages were associated with NPC but limited to anti-early lytic stage for cHL. NPC and eBL were associated with IgG antibodies across the viral life cycle; cHL with antibodies in the early lytic, late lytic and glyco-protein stages; and NKTCL with antibodies in the latent, immediate early lytic and early lytic phases. EBNA3A, BBLF1, BDLF4, and BLRF2 IgG antibodies were associated with all cancer types.Conclusions: Our observed similarities and differences across four EBV-associated cancers may inform EBV-related oncogenesis.Impact: Understanding the comparative humoral immune response across EBV-related cancers may aid in identifying shared etiologic roles of EBV proteins and inform unique pathogenic processes for each cancer.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Klinisk laboratoriemedicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Clinical Laboratory Medicine (hsv//eng)

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