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  • Urbiola-Salvador, VictorUniv Gdansk, Intercollegiate Fac Biotechnol, Gdansk, Poland.;Univ Gdansk, Med Univ Gdansk, Gdansk, Poland. (author)

Plasma protein changes reflect colorectal cancer development and associated inflammation

  • Article/chapterEnglish2023

Publisher, publication year, extent ...

  • Frontiers Media S.A.2023
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-504204
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-504204URI
  • https://doi.org/10.3389/fonc.2023.1158261DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Introduction: Colorectal cancer (CRC) is the third most common malignancy and the second leading cause of death worldwide. Efficient non-invasive blood-based biomarkers for CRC early detection and prognosis are urgently needed.Methods: To identify novel potential plasma biomarkers, we applied a proximity extension assay (PEA), an antibody-based proteomics strategy to quantify the abundance of plasma proteins in CRC development and cancer-associated inflammation from few mu L of plasma sample.Results: Among the 690 quantified proteins, levels of 202 plasma proteins were significantly changed in CRC patients compared to age-and-sex-matched healthy subjects. We identified novel protein changes involved in Th17 activity, oncogenic pathways, and cancer-related inflammation with potential implications in the CRC diagnosis. Moreover, the interferon gamma (IFNG), interleukin (IL) 32, and IL17C were identified as associated with the early stages of CRC, whereas lysophosphatidic acid phosphatase type 6 (ACP6), Fms-related tyrosine kinase 4 (FLT4), and MANSC domain-containing protein 1 (MANSC1) were correlated with the late-stages of CRC.Discussion: Further study to characterize the newly identified plasma protein changes from larger cohorts will facilitate the identification of potential novel diagnostic, prognostic biomarkers for CRC.

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  • Jablonska, AgnieszkaUniv Gdansk, Intercollegiate Fac Biotechnol, Gdansk, Poland.;Univ Gdansk, Med Univ Gdansk, Gdansk, Poland. (author)
  • Miroszewska, DominikaUniv Gdansk, Intercollegiate Fac Biotechnol, Gdansk, Poland.;Univ Gdansk, Med Univ Gdansk, Gdansk, Poland. (author)
  • Huang, QianruShanghai Jiao Tong Univ, Sch Med, Ctr Immune Related Dis, Shanghai Inst Immunol,Dept Resp & Crit Care Med,Ru, Shanghai, Peoples R China. (author)
  • Duzowska, KatarzynaMed Univ Gdansk, 3P Med Lab, Gdansk, Poland. (author)
  • Drezek-Chyla, KingaMed Univ Gdansk, 3P Med Lab, Gdansk, Poland. (author)
  • Zdrenka, MarekProf Franciszek Lukaszczyk Mem Hosp, Oncol Ctr, Dept Tumor Pathol & Pathomorphol, Bydgoszcz, Poland. (author)
  • Srutek, EwaProf Franciszek Lukaszczyk Mem Hosp, Oncol Ctr, Dept Tumor Pathol & Pathomorphol, Bydgoszcz, Poland. (author)
  • Szylberg, LukaszProf Franciszek Lukaszczyk Mem Hosp, Oncol Ctr, Dept Tumor Pathol & Pathomorphol, Bydgoszcz, Poland.;Nicolaus Copernicus Univ Torun, Dept Obstet Gynaecol & Oncol, Coll Med Bydgoszcz, Bydgoszcz, Poland. (author)
  • Jankowski, MichalNicolaus Copernicus Univ Torun, Ludwik Rydygiers Coll Med Bydgoszcz, Surg Oncol, Ludwik Rydygiers Coll Med Bydgoszcz,Surg Oncol, Torun, Poland.;Prof Franciszek Lukaszczyk Mem Hosp, Oncol Ctr, Dept Surg Oncol, Bydgoszcz, Poland. (author)
  • Bala, DariuszNicolaus Copernicus Univ Torun, Ludwik Rydygiers Coll Med Bydgoszcz, Surg Oncol, Ludwik Rydygiers Coll Med Bydgoszcz,Surg Oncol, Torun, Poland.;Prof Franciszek Lukaszczyk Mem Hosp, Oncol Ctr, Dept Surg Oncol, Bydgoszcz, Poland. (author)
  • Zegarski, WojciechNicolaus Copernicus Univ Torun, Ludwik Rydygiers Coll Med Bydgoszcz, Surg Oncol, Ludwik Rydygiers Coll Med Bydgoszcz,Surg Oncol, Torun, Poland.;Prof Franciszek Lukaszczyk Mem Hosp, Oncol Ctr, Dept Surg Oncol, Bydgoszcz, Poland. (author)
  • Nowikiewicz, TomaszNicolaus Copernicus Univ Torun, Ludwik Rydygiers Coll Med Bydgoszcz, Surg Oncol, Ludwik Rydygiers Coll Med Bydgoszcz,Surg Oncol, Torun, Poland.;Prof Franciszek Lukaszczyk Mem Hosp, Oncol Ctr, Dept Breast Canc & Reconstruct Surg, Bydgoszcz, Poland. (author)
  • Makarewicz, WojciechSpecialist Hosp Koscierzyna, Clin Gen & Oncol Surg, Koscierzyna, Poland. Maria Sklodowska Curie Natl Res Inst Oncol, Dept Tumor Pathol, Krakow, Poland. (author)
  • Adamczyk, Agnieszka (author)
  • Ambicka, Aleksandra (author)
  • Przewoznik, Marcin (author)
  • Harazin-Lechowicz, Agnieszka (author)
  • Rys, Janusz (author)
  • Filipowicz, NataliaMed Univ Gdansk, 3P Med Lab, Gdansk, Poland. (author)
  • Piotrowski, ArkadiuszMed Univ Gdansk, 3P Med Lab, Gdansk, Poland. (author)
  • Dumanski, Jan P.Uppsala universitet,Science for Life Laboratory, SciLifeLab,Institutionen för immunologi, genetik och patologi,Med Univ Gdansk, 3P Med Lab, Gdansk, Poland.;Med Univ Gdansk, Dept Biol & Pharmaceut Bot, Gdansk, Poland.(Swepub:uu)janduman (author)
  • Li, BinShanghai Jiao Tong Univ, Sch Med, Ctr Immune Related Dis, Shanghai Inst Immunol,Dept Resp & Crit Care Med,Ru, Shanghai, Peoples R China. (author)
  • Chen, ZhiUniv Gdansk, Intercollegiate Fac Biotechnol, Gdansk, Poland.;Univ Gdansk, Med Univ Gdansk, Gdansk, Poland.;Univ Oulu, Fac Biochem & Mol Med, Oulu, Finland. (author)
  • Univ Gdansk, Intercollegiate Fac Biotechnol, Gdansk, Poland.;Univ Gdansk, Med Univ Gdansk, Gdansk, Poland.Shanghai Jiao Tong Univ, Sch Med, Ctr Immune Related Dis, Shanghai Inst Immunol,Dept Resp & Crit Care Med,Ru, Shanghai, Peoples R China. (creator_code:org_t)

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