SwePub
Sök i LIBRIS databas

  Extended search

onr:"swepub:oai:DiVA.org:uu-504314"
 

Search: onr:"swepub:oai:DiVA.org:uu-504314" > Structural Basis fo...

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist
  • Sahin, CaglaKarolinska Institutet (author)

Structural Basis for Dityrosine-Mediated Inhibition of α-Synuclein Fibrillization

  • Article/chapterEnglish2022

Publisher, publication year, extent ...

  • 2022-06-24
  • American Chemical Society (ACS),2022
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-504314
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-504314URI
  • https://doi.org/10.1021/jacs.2c03607DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-208098URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:150106632URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • α-Synuclein (α-Syn) is an intrinsically disordered protein which self-assembles into highly organized β-sheet structures that accumulate in plaques in brains of Parkinson’s disease patients. Oxidative stress influences α-Syn structure and self-assembly; however, the basis for this remains unclear. Here we characterize the chemical and physical effects of mild oxidation on monomeric α-Syn and its aggregation. Using a combination of biophysical methods, small-angle X-ray scattering, and native ion mobility mass spectrometry, we find that oxidation leads to formation of intramolecular dityrosine cross-linkages and a compaction of the α-Syn monomer by a factor of √2. Oxidation-induced compaction is shown to inhibit ordered self-assembly and amyloid formation by steric hindrance, suggesting an important role of mild oxidation in preventing amyloid formation.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Østerlund, Eva Christina (author)
  • Österlund, NicklasStockholms universitet,Institutionen för biokemi och biofysik(Swepub:su)nios7191 (author)
  • Costeira-Paulo, JoanaUppsala universitet,Biokemi(Swepub:uu)joaco720 (author)
  • Pedersen, Jannik Nedergaard (author)
  • Christiansen, Gunna (author)
  • Nielsen, Janni (author)
  • Grønnemose, Anne Louise (author)
  • Amstrup, Søren Kirk (author)
  • Tiwari, Manish K. (author)
  • Rao, R. Shyama Prasad (author)
  • Bjerrum, Morten Jannik (author)
  • Ilag, Leopold L.Stockholms universitet,Institutionen för material- och miljökemi (MMK)(Swepub:su)lilag (author)
  • Davies, Michael J. (author)
  • Marklund, Erik,Teknologie doktor,1979-Uppsala universitet,Biokemi,Erik Marklund(Swepub:uu)ermar499 (author)
  • Pedersen, Jan Skov (author)
  • Landreh, MichaelKarolinska Institutet (author)
  • Møller, Ian Max (author)
  • Jørgensen, Thomas J. D. (author)
  • Otzen, Daniel Erik (author)
  • Karolinska InstitutetInstitutionen för biokemi och biofysik (creator_code:org_t)

Related titles

  • In:Journal of the American Chemical Society: American Chemical Society (ACS)144:27, s. 11949-119540002-78631520-5126

Internet link

Find in a library

To the university's database

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view