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Adiposity and sex-s...
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Rask-Andersen, Mathias,1979-Uppsala universitet,Science for Life Laboratory, SciLifeLab,Institutionen för immunologi, genetik och patologi
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Adiposity and sex-specific cancer risk.
- Article/chapterEnglish2023
Publisher, publication year, extent ...
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2023
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electronicrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-505445
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-505445URI
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https://doi.org/10.1016/j.ccell.2023.05.010DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Obesity is associated with several types of cancer and fat distribution, which differs dramatically between sexes, has been suggested to be an independent risk factor. However, sex-specific effects on cancer risk have rarely been studied. Here we estimate the effects of fat accumulation and distribution on cancer risk in females and males. We performed a prospective study in 442,519 UK Biobank participants, for 19 cancer types and additional histological subtypes, with a mean follow-up time of 13.4 years. Cox proportional hazard models were used to estimate the effect of 14 different adiposity phenotypes on cancer rates, and a 5% false discovery rate was considered statistically significant. Adiposity-related traits are associated with all but three cancer types, and fat accumulation is associated with a larger number of cancers compared to fat distribution. In addition, fat accumulation or distribution exhibit differential effects between sexes on colorectal, esophageal, and liver cancer.
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Ivansson, EmmaUppsala universitet,Institutionen för immunologi, genetik och patologi,Science for Life Laboratory, SciLifeLab(Swepub:uu)emfra062
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Höglund, JuliaUppsala universitet,Science for Life Laboratory, SciLifeLab,Institutionen för immunologi, genetik och patologi(Swepub:uu)julho506
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Ek, Weronica E.Uppsala universitet,Science for Life Laboratory, SciLifeLab,Institutionen för immunologi, genetik och patologi(Swepub:uu)werek336
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Karlsson, TorgnyUppsala universitet,Science for Life Laboratory, SciLifeLab,Institutionen för immunologi, genetik och patologi(Swepub:uu)tka28508
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Johansson, ÅsaUppsala universitet,Institutionen för immunologi, genetik och patologi,Science for Life Laboratory, SciLifeLab(Swepub:uu)asjoh108
(author)
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Uppsala universitetScience for Life Laboratory, SciLifeLab
(creator_code:org_t)
Related titles
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In:Cancer Cell41:6, s. 1186-1197.e41535-61081878-3686
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