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The Influence of Cy...
The Influence of Cytochrome P450 Polymorphisms on Pharmacokinetic Profiles and Treatment Outcomes Among Malaria Patients in Sub-Saharan Africa : A Systematic Review
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- Marwa, Karol J. (author)
- Catholic Univ Hlth & Allied Sci, Dept Pharmacol, POB 1464, Mwanza, Tanzania.
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- Kapesa, Anthony (author)
- Catholic Univ Hlth & Allied Sci, Dept Community Med, Mwanza, Tanzania.
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- Kamugisha, Erasmus (author)
- Catholic Univ Hlth & Allied Sci, Dept Biochem, Mwanza, Tanzania.
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- Swedberg, Göte (author)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi
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Catholic Univ Hlth & Allied Sci, Dept Pharmacol, POB 1464, Mwanza, Tanzania Catholic Univ Hlth & Allied Sci, Dept Community Med, Mwanza, Tanzania. (creator_code:org_t)
- Dove Medical Press, 2023
- 2023
- English.
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In: Pharmacogenomics and Personalized Medicine. - : Dove Medical Press. - 1178-7066. ; 16, s. 449-461
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https://uu.diva-port... (primary) (Raw object)
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Abstract
Subject headings
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- Background: Sub-Saharan Africa (SSA) population is genetically diverse and heterogenous thus variability in drug response among individuals is predicted to be high. Cytochrome P450 (CYP450) polymorphisms is a major source of variability in drug response. This systematic review presents the influence of CYP450 single nucleotide polymorphisms (SNPs), particularly CYP3A4*1B, CYP2B6*6 and CYP3A5*3 on antimalarial drug plasma concentrations, efficacy and safety in SSA populations.Methods: Searching for relevant studies was done through Google Scholar, Cochrane Central Register of controlled trials (CENTRAL), PubMed, Medline, LILACS, and EMBASE online data bases. The Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines were used. Two independent reviewers extracted data from the studies.Results: Thirteen studies reporting the influence of CYP450 SNPs on plasma concentrations, efficacy and safety were included in the final data synthesis. CYP3A4*1B, CYP3A5*5, CYP2B6*6 and CYP2C8*2 did not affect antimalarial drug plasma concentration significantly. There was no difference in treatment outcomes between malaria patients with variant alleles and those with wild type alleles.Conclusion: This review reports lack of influence of CYP3A4*1B, CYP3A5*3, CYP2C8*3 and CYP2B6*6 SNPs on PK profiles, efficacy and safety in SSA among P. falciparum malaria patients.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmaceutiska vetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmaceutical Sciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
Keyword
- cytochrome P450 polymorphisms
- review
- antimalarial drugs
- sub-Saharan Africa
- treatment outcomes
- pharmacokinetics
Publication and Content Type
- ref (subject category)
- for (subject category)
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