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Characterization of...
Characterization of therapy-related acute myeloid leukemia : increasing incidence and prognostic implications
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- Nilsson, Christer (author)
- Karolinska Institute,Karolinska Inst, Sweden
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- Linde, Fredrika (author)
- Uppsala University,Uppsala universitet,Institutionen för medicinska vetenskaper,Uppsala Univ, Sweden
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- Hulegardh, Erik (author)
- Sahlgrens Univ Hosp, Dept Hematol, Gothenburg, Sweden.,Sahlgrenska University Hospital
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- Garelius, Hege (author)
- Sahlgrens Univ Hosp, Dept Hematol, Gothenburg, Sweden.,Sahlgrenska University Hospital
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- Lazarevic, Vladimir (author)
- Lund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Leukemi, genetik, epidemiologi,Forskargrupper vid Lunds universitet,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine,Leukemia, Genetics, Epidemiology,Lund University Research Groups,Skåne University Hospital,Skane Univ Hosp, Sweden; Lund Univ, Sweden
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- Antunovic, Petar (author)
- Linköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Region Östergötland, Hematologiska kliniken US
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- Cammenga, Jörg (author)
- Linköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Region Östergötland, Hematologiska kliniken US
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- Deneberg, Stefan (author)
- Karolinska Institute,Karolinska Institutet,Karolinska Inst, Dept Med, Div Hematol, Stockholm, Sweden.
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- Eriksson, Anna, 1977- (author)
- Uppsala universitet,Hematologi,Uppsala Univ, Sweden
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- Jadersten, Martin (author)
- Karolinska Institute,Karolinska Institutet,Karolinska Inst, Dept Med, Div Hematol, Stockholm, Sweden.
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- Bjorkvall, Cecilia Kampe (author)
- Norrland Univ Hosp, Dept Hematol, Umeå, Sweden.,Norrland University Hospital
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- Mollgard, Lars (author)
- Sahlgrens Univ Hosp, Dept Hematol, Gothenburg, Sweden.,Sahlgrenska University Hospital
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- Wennstrom, Lovisa (author)
- Sahlgrens Univ Hosp, Dept Hematol, Gothenburg, Sweden.,Sahlgrenska University Hospital
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- Olander, Emma (author)
- Sundsvall Hosp, Dept Hematol, Sundsvall, Sweden.,Sundsvall Hospital
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- Höglund, Martin (author)
- Uppsala universitet,Hematologi,Uppsala Univ, Sweden
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- Juliusson, Gunnar (author)
- Lund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Leukemi, genetik, epidemiologi,Forskargrupper vid Lunds universitet,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Leukemia, Genetics, Epidemiology,Lund University Research Groups,Skåne University Hospital,Skane Univ Hosp, Sweden; Lund Univ, Sweden
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- Lehmann, Sören (author)
- Uppsala University,Karolinska Institute,Uppsala universitet,Hematologi,Karolinska Inst, Dept Med, Div Hematol, Stockholm, Sweden.,Karolinska Inst, Sweden; Uppsala Univ, Sweden
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(creator_code:org_t)
- 2022-08-25
- 2023
- English.
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In: Haematologica. - : Ferrata Storti Foundation. - 0390-6078 .- 1592-8721. ; 108:4, s. 1015-1025
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Abstract
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- Studies of therapy-related AML (t-AML) are usually performed in selected cohorts and reliable incidence rates are lacking. In this study, we characterized, defined the incidence over time and studied prognostic implications in all t-AML patients diagnosed in Sweden between 1997 and 2015. Data were retrieved from nationwide population-based registries. In total, 6,779 AML patients were included in the study, of whom 686 (10%) had t-AML. The median age for t-AML was 71 years and 392 (57%) patients were females. During the study period, the incidence of t-AML almost doubled with a yearly increase in t-AML of 4.5% (95% confidence interval: 2.8%-6.2%), which contributed significantly to the general increase in AML incidence over the study period. t-AML solidly constituted over 10% of all AML cases during the later period of the study. Primary diagnoses with the largest increase in incidence and decrease in mortality rate during the study period (i.e., breast and prostate cancer) contributed significantly to the increased incidence of t-AML. In multivariable analysis, t-AML was associated with poorer outcome in cytogenetically intermediate-and adverse-risk cases but t-AML had no significant impact on outcome in favorable-risk AML, including core binding leukemias, acute promyelocytic leukemia and AML with mutated NPM1 without FLT3-ITD. We conclude that there is a strong increase in incidence in t-AML over time and that t-AML constitutes a successively larger proportion of the AML cases. Furthermore, we conclude that t-AML confers a poor prognosis in cytogenetically intermediate-and adverse-risk, but not in favorable-risk AML.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Nilsson, Christe ...
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Linde, Fredrika
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Hulegardh, Erik
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Garelius, Hege
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Lazarevic, Vladi ...
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Antunovic, Petar
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show more...
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Cammenga, Jörg
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Deneberg, Stefan
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Eriksson, Anna, ...
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Jadersten, Marti ...
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Bjorkvall, Cecil ...
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Mollgard, Lars
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Wennstrom, Lovis ...
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Olander, Emma
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Höglund, Martin
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Juliusson, Gunna ...
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Lehmann, Sören
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Hematology
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Haematologica
- By the university
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Uppsala University
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Karolinska Institutet
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Lund University
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Linköping University