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  • Grahn, PetraUniv Helsinki, Dept Pediat Orthoped & Traumatol, Stenbackinkatu 9, PL 281, Helsinki 00029, Finland.;Helsinki Univ Hosp, Stenbackinkatu 9, PL 281, Helsinki 00029, Finland. (author)

Early disc degeneration in radiotherapy-treated childhood brain tumor survivors

  • Article/chapterEnglish2023

Publisher, publication year, extent ...

  • BioMed Central (BMC),2023
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-506648
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-506648URI
  • https://doi.org/10.1186/s12891-023-06509-4DOI

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  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • BackgroundChildhood brain tumor (BT) survivors have an increased risk of treatment-related late effects, which can reduce health-related quality of life and increase morbidity. This study aimed to investigate lumbar disc degeneration in magnetic resonance imaging (MRI) in adult survivors of radiotherapy-treated childhood BT compared to age and sex-matched population controls.MethodsIn this cross-sectional comparative study, 127 survivors were identified from hospital registries. After a mean follow-up of 20.7 years (range 5-33.1), 67 survivors (mean age 28.4, range 16.2-43.5) were investigated with MRI and compared to 75 sex-matched population-based controls. Evaluated MRI phenotypes included Pfirrmann grading, , intervertebral disc protrusions, extrusions, and high-intensity-zone-lesions (HIZ). Groups were also compared for known risk factors of lumbar intervertebral disc (IVD) degeneration.ResultsChildhood BT survivors had higher Pfirrmann grades than controls at all lumbar levels (all p < 0.001). Lumbar disc protrusions at L4-5 (p = 0.02) and extrusions at L3-4 (p = 0.04), L4-5 (p = 0.004), and L5-S1 (p = 0.01) were significantly more common in the BT group compared to the control. The survivor cohort also had significantly more HIZ-lesons than the controls (n=13 and n=1, p=0.003). Age at diagnosis was associated with lower degree of IVD degeneration (p < 0.01). Blood pressure correlated with IVD degeneration (P < 0.05).ConclusionsSigns of early disc degeneration related to tumor treatment can be seen in the IVDs of survivors. Disc degeneration was more severe in children treated in adolescence.

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  • Remes, TiinaOulu Univ Hosp, Dept Pediat & Adolescent Med, Helsinki, Finland.;Univ Oulu, Res Unit Clin Med, Helsinki, Finland.;Univ Helsinki, Helsinki Univ Hosp, New Childrens Hosp, Dept Child Neurol, Helsinki, Finland. (author)
  • Kivisaari, ReettaUniv Helsinki, Dept Radiol, Helsinki, Finland.;Helsinki Univ Hosp, Helsinki, Finland. (author)
  • Suo-Palosaari, Maria. H. H.Oulu Univ Hosp, Dept Diagnost Radiol, Oulu, Finland.;Univ Oulu, Med Res Ctr Oulu, Res Unit Med Imaging Phys & Technol, Oulu, Finland. Univ Eastern Finland, Kuopio Pediat Res Unit, Kuopio, Finland. (author)
  • Arikoski, Pekka. M. M.Kuopio Univ Hosp, Kuopio, Finland. (author)
  • Koskenkorva, Paivi K. T.Univ Eastern Finland, Dept Clin Radiol, Kuopio, Finland. Turku Univ, Turku Univ Hosp, Dept Pediat & Adolescent Med, Turku, Finland. (author)
  • Lahteenmaki, Paivi M. (author)
  • Lonnqvist, Tuula R. I.Univ Helsinki, Helsinki Univ Hosp, New Childrens Hosp, Dept Child Neurol, Helsinki, Finland. (author)
  • Ojaniemi, Marja. K. K.Univ Oulu, Res Unit Clin Med, Helsinki, Finland. (author)
  • Sirkia, Kirsti H.Helsinki Univ Hosp, Helsinki, Finland.;Univ Helsinki, Dept Pediat & Adolescence, Helsinki, Finland. (author)
  • Sutela, Anna. K. K.Univ Eastern Finland, Dept Clin Radiol, Kuopio, Finland. Turku Univ, Turku Univ Hosp, Dept Pediat & Adolescent Med, Turku, Finland. (author)
  • Toiviainen-Salo, Sanna-MariaUniv Helsinki, Dept Radiol, Helsinki, Finland.;Helsinki Univ Hosp, Helsinki, Finland. (author)
  • Rantala, Heikki M. J.Oulu Univ Hosp, Dept Pediat & Adolescent Med, Helsinki, Finland.;Univ Oulu, Res Unit Clin Med, Helsinki, Finland. (author)
  • Harila-Saari, Arja H.Uppsala universitet,Barnonkologisk och neurologisk forskning(Swepub:uu)arjha456 (author)
  • Niinimaki, JaakkoUniv Oulu, Med Res Ctr Oulu, Res Unit Med Imaging Phys & Technol, Oulu, Finland. Univ Eastern Finland, Kuopio Pediat Res Unit, Kuopio, Finland. (author)
  • Karppinen, JaroOulu Univ Hosp, Oulu, Finland. Finnish Inst Occupat Hlth, Oulu, Finland. Rehabil Serv South Karel Social & Hlth Care Dist, Lappeenranta, Finland. (author)
  • Ahonen, MattiUniv Helsinki, Dept Pediat Orthoped & Traumatol, Stenbackinkatu 9, PL 281, Helsinki 00029, Finland.;Helsinki Univ Hosp, Stenbackinkatu 9, PL 281, Helsinki 00029, Finland. (author)
  • Univ Helsinki, Dept Pediat Orthoped & Traumatol, Stenbackinkatu 9, PL 281, Helsinki 00029, Finland.;Helsinki Univ Hosp, Stenbackinkatu 9, PL 281, Helsinki 00029, Finland.Oulu Univ Hosp, Dept Pediat & Adolescent Med, Helsinki, Finland.;Univ Oulu, Res Unit Clin Med, Helsinki, Finland.;Univ Helsinki, Helsinki Univ Hosp, New Childrens Hosp, Dept Child Neurol, Helsinki, Finland. (creator_code:org_t)

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  • In:BMC Musculoskeletal Disorders: BioMed Central (BMC)24:11471-2474

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