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Application of Nano...
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Zaman, MuhammadUniv Cent Punjab, Fac Pharm, Lahore 54000, Pakistan.
(author)
Application of Nanoprecipitation Technique to Develop Poloxamer-407 Facilitated Solid Lipid Nanoparticles for the Controlled Delivery of Tacrolimus
- Article/chapterEnglish2023
Publisher, publication year, extent ...
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HINDAWI LTD,2023
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electronicrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-507000
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-507000URI
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https://doi.org/10.1155/2023/7356899DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Currently, the solid lipid nanoparticles (SLNs) are utilized as a novel approach for the controlled drug delivery system (CDDS). Tacrolimus (TCM), a lipophilic drug, can easily be encapsulated in the hydrophobic core of these SLNs using nanoprecipitation technique. The current aim was to develop the controlled release Poloxamer (PLX) facilitated TCM loaded SLNs (PLX/TCM-SLNs), followed by their physicochemical evaluations, including chemical compatibility, particle size, surface charge, surface morphology, nature of SLNs, loading efficiency (LE), entrapment efficiency (EE), in vitro drug release studies, release kinetic modeling, and statistical evaluation. Here we also evaluate physicochemical properties of TCM and investigate solubility profile for improvement and dissolution rate of PLX/TCM-SLNs. PLX was used in the process as a polymer due to its low toxicity and weak immunogenic properties. The prepared formulation was characterized by scanning electron microscopy (SEM) images, and Fourier transform infrared spectroscopy (FTIR) has confirmed the compatibility of the selected ingredients, whereas particle size analysis showed that prepared PLX/TCM-SLNs were of nanosized (120:6 +/- 9nm) having zeta potential of - 21.3 Mv. On the other hand, SEM had revealed the smooth and uniform surface of the particle, while X-ray diffraction (XRD) confirmed the uniform surface as crystalline structure of TCM in PLX/TCM-SLNs masked. A satisfactory level of EE (94:5 +/- 2:74%) has also been noticed. Furthermore, in vitro drug release studies have explored the controlled release of drug during 8 hours, following zero order release kinetics and diffusion type of release mechanism. Outcomes of the studies have advocated the successful preparation of SLNs, as controlled release PLX/TCM-SLNs have been prepared efficiently.
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Iqbal, AsmaUniv Lahore, Fac Pharm, Lahore, Pakistan.
(author)
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Sarwar, Hafiz ShoaibUniv Cent Punjab, Fac Pharm, Lahore 54000, Pakistan.
(author)
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Butt, Muhammad HammadUppsala universitet,Institutionen för läkemedelskemi(Swepub:uu)muhbu815
(author)
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Iqbal, Muhammad OmerOcean Univ China, Sch Med & Pharm, Shandong Prov Key Lab Glycoscience & Glycoengineer, Qingdao 266003, Shandong, Peoples R China.;Royal Inst Med Sci, Multan, Pakistan.
(author)
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Nissar, NaveedInst Res & Adv Studies Pharm IRASP, Multan, Pakistan.;Bahauddin Zakariya Univ, Fac Pharm, Multan, Pakistan.
(author)
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Mumtaz, AsmaMultan Med & Dent Coll, Multan, Pakistan.
(author)
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Nazeer, Hafiza YusraInst Res & Adv Studies Pharm IRASP, Multan, Pakistan.
(author)
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Alshammari, AbdulrahmanKing Saud Univ, Coll Pharm, Dept Pharmacol & Toxicol, Post Box 2455, Riyadh 11451, Saudi Arabia.
(author)
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Riaz, Muhammad ShahidUniv Valencia, Fac Pharm, Nutr & Food Sci Area, Prevent Med & Publ Hlth Food Sci Toxicol & Forens, Avda Vicent Andres Estelles S-N Burjassot, Valencia 46100, Spain.
(author)
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Univ Cent Punjab, Fac Pharm, Lahore 54000, Pakistan.Univ Lahore, Fac Pharm, Lahore, Pakistan.
(creator_code:org_t)
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In:International Journal of Polymer Science: HINDAWI LTD20231687-94221687-9430
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Iqbal, Asma
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