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Metabolism-dependen...
Metabolism-dependent activation and toxicity of chemicals in nasal glands
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- Brittebo, Eva B (author)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap,Toxicology
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(creator_code:org_t)
- 1997
- 1997
- English.
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In: Mutation research. - 0027-5107 .- 1873-135X. ; 380:1-2, s. 61-75
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- The mucosae of the nasal passages contain a large amount of glands which express secretory proteins as well as phase I and phase II biotransformation enzymes. In this review the metabolic activation, covalent binding and toxicity of chemicals in the Bowman's glands in the olfactory mucosa, in the sere-mucous glands in the nasal septum and in the lateral nasal glands and maxillary glands around the maxillary sinuses are discussed. Light microscopic autoradiographic studies have demonstrated a selective covalent binding of nasal toxicants and carcinogens such as halogenated hydrocarbons and N-nitrosamines, especially in the Bowman's glands following a single systemic exposure, suggesting a high rate of metabolic activation of chemicals in these glands. Special attention is put on the herbicide dichlobenil which induces necrosis in the olfactory mucosa following a cytochrome-P450-mediated metabolic activation and covalent binding in the Bowman's glands.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmaceutiska vetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmaceutical Sciences (hsv//eng)
Keyword
- Bowman's gland
- sero-mucous gland
- lateral nasal gland
- maxillary gland
- olfactory mucosa
- nasal mucosa
- nasal toxicity
- nasal P450
- dichlobenil
- PHARMACY
- FARMACI
Publication and Content Type
- ref (subject category)
- art (subject category)
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