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Streptococcus Speci...
Streptococcus Species Abundance in the Gut Is Linked to Subclinical Coronary Atherosclerosis in 8973 Participants From the SCAPIS Cohort
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- Sayols-Baixeras, Sergi (author)
- Uppsala University,Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab,CIBER Cardiovascular Diseases (CIBERCV), Instituto de Salud Carlos III, Madrid, Spain,Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV)
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- Dekkers, Koen (author)
- Uppsala University,Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab
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- Baldanzi, Gabriel (author)
- Uppsala University,Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab
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- Jönsson, Daniel (author)
- Malmö University,Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups,Swedish Public Dental Care of Skåne
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- Hammar, Ulf (author)
- Uppsala University,Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab
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- Lin, Yi-Ting, 1981- (author)
- Karolinska Institute,Uppsala universitet,Molekylär epidemiologi,Kardiologi,Klinisk epidemiologi,Division of Family Medicine and Primary Care, Department of Neurobiology, Care Science and Society, Karolinska Institutet, Huddinge, Sweden
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- Ahmad, Shafqat (author)
- Uppsala University,Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab,Preventive Medicine Division, Harvard Medical School, Brigham and Women’s Hospital, Boston, MA
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- Nguyen, Diem, PhD (author)
- Uppsala University,Uppsala universitet,Science for Life Laboratory, SciLifeLab,Molekylär epidemiologi
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- Varotsis, Georgios (author)
- Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab
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- Pita, Sara (author)
- Technical University of Denmark
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- Nielsen, Nynne (author)
- Clinical Microbiomics
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Eklund, Aron C (author)
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Holm, Jacob B (author)
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Nielsen, H Bjørn (author)
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- Ericson, Ulrika (author)
- Lund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups
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- Brunkwall, Louise (author)
- Lund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups,Region Skåne,Clinical Studies Sweden-Forum South
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- Ottosson, Filip (author)
- Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups,Danish Serum Institute, Copenhagen
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- Larsson, Anna (author)
- Lund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups
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- Ericson, Dan (author)
- Malmö University
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- Klinge, Björn (author)
- Malmö University
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- Nilsson, Peter M (author)
- Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups,Skåne University Hospital
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- Malinovschi, Andrei, 1978- (author)
- Uppsala University,Uppsala universitet,Integrativ Fysiologi,Klinisk fysiologi,Lung- allergi- och sömnforskning
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- Lind, Lars (author)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Klinisk epidemiologi
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- Bergström, Göran, 1964 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
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- Sundström, Johan, Professor, 1971- (author)
- Uppsala universitet,Klinisk epidemiologi,University of New South Wales
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- Ärnlöv, Johan, 1970- (author)
- Dalarna University College,Högskolan Dalarna,Medicinsk vetenskap,Karolinska Institutet, Huddinge
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- Engström, Gunnar (author)
- Lund University,Lunds universitet,Kardiovaskulär forskning - epidemiologi,Forskargrupper vid Lunds universitet,Cardiovascular Research - Epidemiology,Lund University Research Groups
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- Smith, J Gustav (author)
- Gothenburg University,Göteborgs universitet,University of Gothenburg,Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Heart Failure and Mechanical Support,Forskargrupper vid Lunds universitet,Molecular Epidemiology and Cardiology,Cardiovascular Epigenetics,WCMM- Wallenberg center för molekylär medicinsk forskning,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups,WCMM-Wallenberg Centre for Molecular Medicine,Sahlgrenska University Hospital,Skåne University Hospital,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
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- Orho-Melander, Marju (author)
- Lund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups
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- Fall, Tove, 1979- (author)
- Uppsala University,Uppsala universitet,Science for Life Laboratory, SciLifeLab,Molekylär epidemiologi
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(creator_code:org_t)
- 2023
- 2023
- English.
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In: Circulation. - : Lippincott Williams & Wilkins. - 0009-7322 .- 1524-4539. ; 148:6, s. 459-472
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Abstract
Subject headings
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- Background: Gut microbiota have been implicated in atherosclerotic disease, but their relation with subclinical coronary atherosclerosis is unclear. This study aimed to identify associations between the gut microbiome and computed tomography-based measures of coronary atherosclerosis and to explore relevant clinical correlates.Methods: We conducted a cross-sectional study of 8973 participants (50 to 65 years of age) without overt atherosclerotic disease from the population-based SCAPIS (Swedish Cardiopulmonary Bioimage Study). Coronary atherosclerosis was measured using coronary artery calcium score and coronary computed tomography angiography. Gut microbiota species abundance and functional potential were assessed with shotgun metagenomics sequencing of stool, and associations with coronary atherosclerosis were evaluated with multivariable regression models adjusted for cardiovascular risk factors. Associated species were evaluated for association with inflammatory markers, metabolites, and corresponding species in saliva.Results: The mean age of the study sample was 57.4 years, and 53.7% were female. Coronary artery calcification was detected in 40.3%, and 5.4% had at least 1 stenosis with >50% occlusion. Sixty-four species were associated with coronary artery calcium score independent of cardiovascular risk factors, with the strongest associations observed for Streptococcus anginosus and Streptococcus oralis subsp oralis (P<1×10-5). Associations were largely similar across coronary computed tomography angiography-based measurements. Out of the 64 species, 19 species, including streptococci and other species commonly found in the oral cavity, were associated with high-sensitivity C-reactive protein plasma concentrations, and 16 with neutrophil counts. Gut microbial species that are commonly found in the oral cavity were negatively associated with plasma indole propionate and positively associated with plasma secondary bile acids and imidazole propionate. Five species, including 3 streptococci, correlated with the same species in saliva and were associated with worse dental health in the Malmö Offspring Dental Study. Microbial functional potential of dissimilatory nitrate reduction, anaerobic fatty acid β-oxidation, and amino acid degradation were associated with coronary artery calcium score.Conclusions: This study provides evidence of an association of a gut microbiota composition characterized by increased abundance of Streptococcus spp and other species commonly found in the oral cavity with coronary atherosclerosis and systemic inflammation markers. Further longitudinal and experimental studies are warranted to explore the potential implications of a bacterial component in atherogenesis.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Keyword
- Streptococcus
- atherosclerosis
- gastrointestinal microbiome
- metagenomics
- tomography
- Clinical Physiology
- Klinisk fysiologi
- Klinisk bakteriologi
- Clinical Bacteriology
- Infektionssjukdomar
- Infectious Diseases
- Fysiologi
- Physiology
Publication and Content Type
- ref (subject category)
- art (subject category)
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Sayols-Baixeras, ...
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Dekkers, Koen
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Baldanzi, Gabrie ...
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Jönsson, Daniel
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Hammar, Ulf
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Lin, Yi-Ting, 19 ...
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show more...
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Ahmad, Shafqat
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Nguyen, Diem, Ph ...
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Varotsis, Georgi ...
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Pita, Sara
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Nielsen, Nynne
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Eklund, Aron C
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Holm, Jacob B
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Nielsen, H Bjørn
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Ericson, Ulrika
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Brunkwall, Louis ...
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Ottosson, Filip
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Larsson, Anna
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Ericson, Dan
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Klinge, Björn
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Nilsson, Peter M
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Malinovschi, And ...
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Lind, Lars
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Bergström, Göran ...
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Sundström, Johan ...
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Ärnlöv, Johan, 1 ...
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Engström, Gunnar
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Smith, J Gustav
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Orho-Melander, M ...
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Fall, Tove, 1979 ...
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MEDICAL AND HEAL ...
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and Health Sciences
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and Public Health Gl ...
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MEDICAL AND HEAL ...
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Circulation
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Uppsala University
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Högskolan Dalarna
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Karolinska Institutet
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Lund University
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University of Gothenburg