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Development of new ...
Development of new approach methods for the identification and characterization of endocrine metabolic disruptors : a PARC project
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- Braeuning, Albert (author)
- German Fed Inst Risk Assessment, Dept Food Safety, Berlin, Germany.
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- Balaguer, Patrick (author)
- Univ Montpellier, IRCM Inst Rech Cancerol Montpellier, Inserm, U1194,ICM, Montpellier, France.
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- Bourguet, William (author)
- Univ Montpellier, CBS Ctr Biol Structurale, CNRS, Inserm, Montpellier, France.
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- Carreras-Puigvert, Jordi (author)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap,Science for Life Laboratory, SciLifeLab
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- Feiertag, Katreece (author)
- German Fed Inst Risk Assessment, Dept Pesticides Safety, Berlin, Germany.
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- Kamstra, Jorke H. (author)
- Univ Utrecht, Inst Risk Assessment Sci, Fac Vet Med, Dept Populat Hlth Sci, Utrecht, Netherlands.
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- Knapen, Dries (author)
- Univ Antwerp, Dept Vet Sci, Zebrafishlab Vet Physiol & Biochem, Antwerp, Belgium.
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- Lichtenstein, Dajana (author)
- German Fed Inst Risk Assessment, Dept Food Safety, Berlin, Germany.
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- Marx-Stoelting, Philip (author)
- German Fed Inst Risk Assessment, Dept Pesticides Safety, Berlin, Germany.
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- Rietdijk, Jonne (author)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap,Science for Life Laboratory, SciLifeLab
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- Schubert, Kristin (author)
- UFZ Helmholtz Ctr Environm Res, Dept Mol Syst Biol, Leipzig, Germany.
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- Spjuth, Ola, Professor, 1977- (author)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap,Science for Life Laboratory, SciLifeLab
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- Stinckens, Evelyn (author)
- Univ Antwerp, Dept Vet Sci, Zebrafishlab Vet Physiol & Biochem, Antwerp, Belgium.
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- Thedieck, Kathrin (author)
- Univ Innsbruck, Inst Biochem, Innsbruck, Austria.;Univ Innsbruck, Ctr Mol Biosci Innsbruck, Innsbruck, Austria.
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- van den Boom, Rik (author)
- Univ Antwerp, Dept Vet Sci, Zebrafishlab Vet Physiol & Biochem, Antwerp, Belgium.
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- Vergauwen, Lucia (author)
- Univ Antwerp, Dept Vet Sci, Zebrafishlab Vet Physiol & Biochem, Antwerp, Belgium.
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- von Bergen, Martin (author)
- UFZ Helmholtz Ctr Environm Res, Dept Mol Syst Biol, Leipzig, Germany.
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- Wewer, Neele (author)
- German Fed Inst Risk Assessment, Dept Food Safety, Berlin, Germany.
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- Zalko, Daniel (author)
- Univ Toulouse, Univ Paul Sabatier UPS,Inst Natl Rech Pour Agr Ali, Ecole Natl Veterinaire Toulouse ENVT,INP Purpan, Inst Natl Rech Agr,Toxalim Res Ctr Food Toxicol, Toulouse, France.
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German Fed Inst Risk Assessment, Dept Food Safety, Berlin, Germany Univ Montpellier, IRCM Inst Rech Cancerol Montpellier, Inserm, U1194,ICM, Montpellier, France. (creator_code:org_t)
- Frontiers Media SA, 2023
- 2023
- English.
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In: Frontiers in Toxicology. - : Frontiers Media SA. - 2673-3080. ; 5
- Related links:
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.3...
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Abstract
Subject headings
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- In past times, the analysis of endocrine disrupting properties of chemicals has mainly been focused on (anti-)estrogenic or (anti-)androgenic properties, as well as on aspects of steroidogenesis and the modulation of thyroid signaling. More recently, disruption of energy metabolism and related signaling pathways by exogenous substances, so-called metabolism-disrupting chemicals (MDCs) have come into focus. While general effects such as body and organ weight changes are routinely monitored in animal studies, there is a clear lack of mechanistic test systems to determine and characterize the metabolism-disrupting potential of chemicals. In order to contribute to filling this gap, one of the project within EU-funded Partnership for the Assessment of Risks of Chemicals (PARC) aims at developing novel in vitro methods for the detection of endocrine metabolic disruptors. Efforts will comprise projects related to specific signaling pathways, for example, involving mTOR or xenobiotic-sensing nuclear receptors, studies on hepatocytes, adipocytes and pancreatic beta cells covering metabolic and morphological endpoints, as well as metabolism-related zebrafish-based tests as an alternative to classic rodent bioassays. This paper provides an overview of the approaches and methods of these PARC projects and how this will contribute to the improvement of the toxicological toolbox to identify substances with endocrine disrupting properties and to decipher their mechanisms of action.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)
Keyword
- endocrine metabolic disruption
- energy metabolism
- obesogens
- nuclear receptors
- adipocytes
- liver
Publication and Content Type
- ref (subject category)
- art (subject category)
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Braeuning, Alber ...
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Balaguer, Patric ...
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Bourguet, Willia ...
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Carreras-Puigver ...
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Feiertag, Katree ...
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Kamstra, Jorke H ...
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Knapen, Dries
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Lichtenstein, Da ...
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Marx-Stoelting, ...
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Rietdijk, Jonne
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Schubert, Kristi ...
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Spjuth, Ola, Pro ...
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Stinckens, Evely ...
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Thedieck, Kathri ...
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van den Boom, Ri ...
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Vergauwen, Lucia
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von Bergen, Mart ...
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Wewer, Neele
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Zalko, Daniel
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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Frontiers in Tox ...
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Uppsala University