Search: onr:"swepub:oai:DiVA.org:uu-508584" >
ADAR1-mediated RNA ...
ADAR1-mediated RNA editing promotes B cell lymphomagenesis
-
- Pecori, Riccardo (author)
- German Canc Res Ctr, Div Immune Divers D150, Heidelberg, Germany.;Helmholtz Inst Translat Oncol HI TRON, Mainz, Germany.
-
- Ren, Weicheng (author)
- Karolinska Institutet
-
- Pirmoradian, Mohammad (author)
- Karolinska Inst, Dept Biosci & Nutr, Stockholm, Sweden.
-
show more...
-
- Binder, Marco (author)
- German Canc Res Ctr, Div Virus Associated Carcinogenesis F170, Res Grp Dynam Early Viral Infect & Innate Antivira, Heidelberg, Germany.
-
Papavasiliou, Nina (author)
-
- Wang, Xianhuo (author)
- Tianjin Med Univ, Canc Inst & Hosp, Natl Clin Res Ctr Canc, Dept Lymphoma,Key Lab Canc Prevent & Therapy, Tianjin, Peoples R China.
-
- Liu, Dongbing (author)
- BGI Shenzhen, Shenzhen, Peoples R China.;Shenzhen Key Lab Genom, Guangdong Prov Key Lab Human Dis Genom, Shenzhen, Peoples R China.
-
- Berglund, Mattias (author)
- Uppsala universitet,Cancerimmunterapi,Karolinska Inst, Dept Biosci & Nutr, Stockholm, Sweden.
-
- Li, Wei (author)
- Tianjin Med Univ, Canc Inst & Hosp, Natl Clin Res Ctr Canc, Dept Lymphoma,Key Lab Canc Prevent & Therapy, Tianjin, Peoples R China.
-
- Tasakis, Rafail Nikolaos (author)
- German Canc Res Ctr, Div Immune Divers D150, Heidelberg, Germany.;Heidelberg Univ, Grad Program Biosci, Heidelberg, Germany.
-
- Di Giorgio, Salvatore (author)
- German Canc Res Ctr, Div Immune Divers D150, Heidelberg, Germany.
-
- Ye, Xiaofei (author)
- Karolinska Inst, Dept Biosci & Nutr, Stockholm, Sweden.;Tianjin Med Univ, Canc Inst & Hosp, Natl Clin Res Ctr Canc, Dept Lymphoma,Key Lab Canc Prevent & Therapy, Tianjin, Peoples R China.
-
- Li, Xiaobo (author)
- BGI Shenzhen, Shenzhen, Peoples R China.;Shenzhen Key Lab Genom, Guangdong Prov Key Lab Human Dis Genom, Shenzhen, Peoples R China.
-
- Wu, Kui (author)
- BGI Shenzhen, Shenzhen, Peoples R China.;Shenzhen Key Lab Genom, Guangdong Prov Key Lab Human Dis Genom, Shenzhen, Peoples R China.
-
- Helm, Dominic (author)
- German Canc Res Ctr, Prote Core Facil W120, Heidelberg, Germany.
-
- Arnold, Annette (author)
- German Canc Res Ctr, Div Immune Divers D150, Heidelberg, Germany.
-
- Wust, Sandra (author)
- German Canc Res Ctr, Div Virus Associated Carcinogenesis F170, Res Grp Dynam Early Viral Infect & Innate Antivira, Heidelberg, Germany.
-
- Schneider, Martin (author)
- German Canc Res Ctr, Prote Core Facil W120, Heidelberg, Germany.
-
Selvasaravanan, Karthik-Devi (author)
-
Fuell, Yvonne (author)
-
- Stafforst, Thorsten (author)
- Univ Tubingen, Interfac Inst Biochem, Tubingen, Germany.
-
- Amini, Rose-Marie (author)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi,Science for Life Laboratory, SciLifeLab
-
- Sonnevi, Kristina (author)
- Karolinska Institutet
-
- Enblad, Gunilla (author)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi
-
- Sander, Birgitta (author)
- Karolinska Institutet
-
- Wahlin, Bjorn Engelbrekt (author)
- Karolinska Inst, Dept Med, Hematol Unit, Solna, Sweden.;Karolinska Univ Hosp, Med Unit Hematol, Solna, Sweden.
-
- Zhang, Huilai (author)
- Tianjin Med Univ, Canc Inst & Hosp, Natl Clin Res Ctr Canc, Dept Lymphoma,Key Lab Canc Prevent & Therapy, Tianjin, Peoples R China.
-
- Papavasiliou, F. Nina (author)
- German Canc Res Ctr, Div Immune Divers D150, Heidelberg, Germany.
-
- Pan-Hammarstrom, Qiang (author)
- Karolinska Institutet
-
show less...
-
Karolinska Institutet German Canc Res Ctr, Div Immune Divers D150, Heidelberg, Germany;Helmholtz Inst Translat Oncol HI TRON, Mainz, Germany. (creator_code:org_t)
- Cell Press, 2023
- 2023
- English.
-
In: iScience. - : Cell Press. - 2589-0042. ; 26:6
- Related links:
-
https://doi.org/10.1...
-
show more...
-
https://uu.diva-port... (primary) (Raw object)
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
http://kipublication...
-
show less...
Abstract
Subject headings
Close
- Diffuse large B cell lymphoma (DLBCL) is one of the most common types of aggressive lymphoid malignancies. Here, we explore the contribution of RNA editing to DLBCL pathogenesis. We observed that DNA mutations and RNA editing events are often mutually exclusive, suggesting that tumors can modulate pathway outcomes by altering sequences at either the genomic or the transcriptomic level. RNA editing targets transcripts within known disease-driving pathways such as apoptosis, p53 and NF-kappa B signaling, as well as the RIG-I-like pathway. In this context, we show that ADAR1-mediated editing within MAVS transcript positively correlates with MAVS protein expression levels, associating with increased interferon/NF-kappa B signaling and T cell exhaustion. Finally, using targeted RNA base editing tools to restore editing within MAVS 3 ' UTR in ADAR1-deficient cells, we demonstrate that editing is likely to be causal to an increase in downstream signaling in the absence of activation by canonical nucleic acid receptor sensing.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
-
iScience
(Search for host publication in LIBRIS)
To the university's database
- By the author/editor
-
Pecori, Riccardo
-
Ren, Weicheng
-
Pirmoradian, Moh ...
-
Binder, Marco
-
Papavasiliou, Ni ...
-
Wang, Xianhuo
-
show more...
-
Liu, Dongbing
-
Berglund, Mattia ...
-
Li, Wei
-
Tasakis, Rafail ...
-
Di Giorgio, Salv ...
-
Ye, Xiaofei
-
Li, Xiaobo
-
Wu, Kui
-
Helm, Dominic
-
Arnold, Annette
-
Wust, Sandra
-
Schneider, Marti ...
-
Selvasaravanan, ...
-
Fuell, Yvonne
-
Stafforst, Thors ...
-
Amini, Rose-Mari ...
-
Sonnevi, Kristin ...
-
Enblad, Gunilla
-
Sander, Birgitta
-
Wahlin, Bjorn En ...
-
Zhang, Huilai
-
Papavasiliou, F. ...
-
Pan-Hammarstrom, ...
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Cell and Molecul ...
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Cancer and Oncol ...
- Articles in the publication
-
iScience
- By the university
-
Uppsala University
-
Karolinska Institutet